scholarly journals The Prebiotic-Like Effects of Coprinus comatus Polysaccharides on Gut Microbiota in Normal Mice and Those with Acute Alcoholic Liver Injury: A Comparative Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Weidong Li ◽  
Yongxia Wang ◽  
Min Sun ◽  
Yuting Liang ◽  
Xiaoqing Cai ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Comparative Study ◽  
Relative Abundance ◽  
Alcohol Intake ◽  
Alcoholic Liver Injury ◽  
Alcohol Group ◽  
Coprinus Comatus ◽  
Positive Effects ◽  
Microbiota Structure

This study aims to investigate the prebiotic-like effects of Coprinus comatus polysaccharides (CCP) on gut microbiota. Mice were divided into four groups: normal group (NG), alcohol group (AG), polysaccharides group (PG), and alcohol + polysaccharides group (APG). The gut microbiota structure of feces was analyzed by determining the V3-V4 region sequence in 16S rDNA. The results showed CCP could increase the diversity of gut microbiota. Compared with NG, PG had a significantly higher relative abundance of Firmicutes and Lactobacillaceae and a lower abundance of Rikenellaceae. These changes in gut microbiota result in positive effects on gut due to a series of prebiotic-like effects of CCP. At the same time, CCP could improve some adverse changes in gut microbiota caused by acute alcohol intake, such as the increased proportion of Firmicutes, Bacteroidetes, Muribaculaceae, and Lachnospiraceae and the decreased proportion of Rikenellaceae. In conclusion, the CCP has certain prebiotic effects not only on normal mice but also on mice with acute alcoholic liver injury.

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

2016 ◽  
Vol 7 (6) ◽  
pp. 2898-2908 ◽  
Author(s):  
Xiaxia Cai ◽  
Lei Bao ◽  
Nan Wang ◽  
Jinwei Ren ◽  
Qihe Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Injury ◽  
Dietary Nucleotides

The present study aims to investigate whether nucleotides ameliorate alcoholic liver injury and explores the possible mechanism.

Crosstalk between gut microbiota and host lipid metabolism in a mouse model of alcoholic liver injury by chronic baijiu or ethanol feeding

2022 ◽  
Author(s):  
Cheng Fang ◽  
Qingwu Zhou ◽  
Qingyang Liu ◽  
Wei Jia ◽  
Yan Xu
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Alcoholic Beverage ◽  
Alcoholic Liver Injury ◽  
Ethanol Feeding

This study demonstrates that compounds in baijiu, a traditional Chinese alcoholic beverage, can attenuate the development of ethanol-induced liver injury by regulating the crosstalk between gut microbiota and host lipid metabolism.

Gut dysbiosis correction contributes to the hepatoprotective effects of Thymus quinquecostatus Celak extract against alcohol through the gut–liver axis

2021 ◽  
Author(s):  
Xin Yan ◽  
Yu Wang ◽  
Xue-Yang Ren ◽  
Xiao-Yun Liu ◽  
Jia-Mu Ma ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Injury ◽  
Gut Dysbiosis ◽  
Hepatoprotective Effects ◽  
Gut Microbiota Dysbiosis

Gut microbiota dysbiosis correction contributes to the hepatoprotective effects of Thymus quinquecostatus Celak extract (TQE) against alcoholic liver injury through gut–liver axis modulation.

Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake

2021 ◽  
Vol 12 (7) ◽  
pp. 2925-2937
Author(s):  
Zhenwei Yi ◽  
Xiaofeng Liu ◽  
Lihong Liang ◽  
Guangqiang Wang ◽  
Zhiqiang Xiong ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Alcohol Intake ◽  
Underlying Mechanism ◽  
Antrodia Camphorata ◽  
Hepatoprotective Effects

In this study, we investigated the hepatoprotective effects of AdA and the underlying mechanism at the liver metabolomics and gut microbiota levels under alcohol-induced liver injury conditions.

Fermented ginseng improved alcohol liver injury in association with changes in the gut microbiota of mice

2019 ◽  
Vol 10 (9) ◽  
pp. 5566-5573 ◽  
Author(s):  
Jingjing Fan ◽  
Yushan Wang ◽  
Ying You ◽  
Zhiyi Ai ◽  
Weichang Dai ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Intestinal Flora ◽  
Alcoholic Liver Injury ◽  
Fermented Ginseng

Fermented ginseng can alleviate alcoholic liver injury by adjusting the intestinal flora.

scholarly journals Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-αExpression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Jing-Hua Peng ◽  
Tuan Cui ◽  
Zhao-Lin Sun ◽  
Fu Huang ◽  
Liang Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protein Expression ◽  
Alcohol Intake ◽  
Alcoholic Liver Injury ◽  
Chronic Alcohol ◽  
Gamma Glutamyl Transpeptidase ◽  
Chronic Alcoholic ◽  
Necrosis Factor Alpha ◽  
Puerariae Radix

Kudzu (Pueraria lobata) is one of the earliest medicinal plants used to treat alcohol abuse in traditional Chinese medicine for more than a millennium. However, little is known about its effects on chronic alcoholic liver injury. Therefore, the present study observed the effects of puerariae radix extract (RPE) on chronic alcoholic liver injury as well as Kupffer cells (KCs) activation to release tumor necrosis factor alpha (TNF-α) induced by gut-derived endotoxin in rats and macrophage cell line. RPE was observed to alleviate the pathological changes and lipids deposition in liver tissues as well as the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic gamma-glutamyl transpeptidase (GGT) activity. Meanwhile, RPE inhibited KCs activation and subsequent hepatic TNF-αexpression and downregulated the protein expression of endotoxin receptors, lipopolysaccharide binding protein (LBP), CD14, Toll-like receptor (TLR) 2, and TLR4 in chronic alcohol intake rats. Furthermore, anin vitrostudy showed that RPE inhibited the expression of TNF-αand endotoxin receptors, CD14 and TLR4, induced by LPS in RAW264.7 cells. In summary, this study demonstrated that RPE mitigated liver damage and lipid deposition induced by chronic alcohol intake in rats, as well as TNF-αrelease, protein expression of endotoxin receptorsin vivoorin vitro.

scholarly journals Scutellarein Aggravated Carbon Tetrachloride-Induced Chronic Liver Injury in Gut Microbiota-Dysbiosis Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Zhimin Miao ◽  
Yong Lai ◽  
Yingying Zhao ◽  
Lingmin Chen ◽  
Jianeng Zhou ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Relative Abundance ◽  
Function Analysis ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Chronic Liver Injury ◽  
Cyp2e1 Expression ◽  
Factor Α ◽  
Gut Microbiota Dysbiosis

Scutellarein (SCU) is an herbal flavonoid, showing hepatoprotective potentials. The study was aimed to investigate whether the hepatoprotective effect of SCU is dependent on the integrity of gut microbiota. Mice received repeated intraperitoneal injections of CCl4, followed with or without SCU treatment (15, 30, and 60 mg/kg). Gut microbial community of mice was disrupted by administrating a cocktail of antibiotics (ampicillin, neomycin sulfate, metronidazole, and vancomycin) in drinking water. The results showed SCU plus antibiotics aggravated CCl4-induced chronic liver injury, as demonstrated by liver function analysis, histological analysis, and TUNEL assay. SCU activated CYP2E1 expression and worsened CYP2E1-mediated lipid peroxidation and oxidative stress as coadministered with antibiotics. Moreover, when gut microbiota was disrupted by antibiotics, SCU activated IκBα/NF-κB pathway and promoted the release of subsequent proinflammatory cytokines including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). Remarkably, the 16 S rRNA sequencing demonstrated that SCU greatly decreased the relative abundance of Bifidobacterium and Lactobacillus and increased the relative abundance of Enterococcus in gut microbiota-dysbiosis mice. Spearman correlation analysis showed that Lactobacillus was positively correlated with SOD and negatively correlated with AST. Collectively, the hepatoprotective effect of SCU is reversed under antibiotics intervention, which may partly involve the activation of CYP2E1 and IκBα/NF-κB pathway and diminishment of Lactobacillus.

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