Early Identification of Residual Tumors following Microwave Ablation Using Contrast-Enhanced Ultrasonography in a Rabbit VX2 Liver Cancer Model

Objective. It is difficult to evaluate the ablation effect immediately after thermal ablation of liver cancer by clinical imaging methods, due to the immediate formation of an annular inflammatory reaction band (IRB). This study is aimed at exploring the early identification indicators of the IRB and residual tumor postmicrowave ablation (MVA) using contrast-enhanced ultrasonography (CEUS). Methods. MVA was used to inactivate part of the tumor nodules in rabbit VX2 liver cancer models, leading to the coexistence of the IRB with residual tumors. Quantitative analysis of the perfusion parameters of the tumor and ablation zone was performed using CEUS, followed by liver biopsy and VEGFR-2 immunohistochemical staining. Results. All rabbits successfully tolerated VX2 tumor inoculation and MVA operation. No statistically significant difference existed between the IRB vs. residual tumors, the IRB vs. junctional areas, and residual tumors postablation vs. VX2 tumors before ablation in regional blood volume, blood velocity, and blood flow estimated by parameters A, k, and A∗k of CEUS quantitative analysis. There was a statistically significant difference between the IRB and normal liver parenchyma in regional blood velocity and blood flow (p=0.005 and p=0.023, respectively). Normal liver parenchyma showed nonspecific VEGFR-2 staining, while VX2 tumor before ablation and residual tumor after ablation both showed positive VEGFR-2 staining; the necrosis zone showed negative staining by VEGFR-2 immunohistochemical staining. Conclusion. MVA had no significant effect on the residual tumor hemodynamics. The blood flow in the IRB increased significantly as compared to normal liver parenchyma, resembling tumor hemodynamic patterns. CEUS can detect residual tumors immediately postablation only when they protrude from the annular-shaped IRB. In addition, VEGFR-2 targeted CEUS may have a great potential for detecting residual tumor after thermal ablation of hepatocellular carcinoma.

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Liver perfusion in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI): comparison of enhancement in Gd-BT-DO3A and Gd-EOB-DTPA in normal liver parenchyma

European Radiology ◽

10.1007/s00330-014-3275-x ◽

2014 ◽

Vol 24 (9) ◽

pp. 2146-2156 ◽

Cited By ~ 14

Author(s):

Hanke J. Schalkx ◽

Marijn van Stralen ◽

Kenneth Coenegrachts ◽

Maurice A. A. J. van den Bosch ◽

Charlotte S. van Kessel ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Liver Perfusion ◽

Normal Liver ◽

Liver Parenchyma ◽

Resonance Imaging ◽

Dce Mri ◽

Dynamic Contrast Enhanced ◽

Normal Liver Parenchyma ◽

Contrast Enhanced

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Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma

European Radiology ◽

10.1007/s00330-008-0929-6 ◽

2008 ◽

Vol 18 (8) ◽

pp. 1577-1586 ◽

Cited By ~ 128

Author(s):

Frank T. C. Tschirch ◽

Anja Struwe ◽

Henrik Petrowsky ◽

Irini Kakales ◽

Borut Marincek ◽

...

Keyword(s):

Liver Cirrhosis ◽

Normal Liver ◽

Liver Parenchyma ◽

Normal Liver Parenchyma ◽

Mr Cholangiography ◽

Contrast Enhanced ◽

Biliary Ducts

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Comparative the clinical value of contrast-enhanced ultrasonography, enhancement CT and MRI for diagnosing of liver lesions

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211142 ◽

2021 ◽

pp. 1-11

Author(s):

Gang Zhang ◽

Dandan Liu

Keyword(s):

Liver Cancer ◽

Primary Liver Cancer ◽

Pathological Examination ◽

Liver Lesions ◽

Clinical Value ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Significant Difference ◽

Contrast Enhanced Ultrasonography ◽

Ct And Mri

BACKGROUND: To investigate the accuracy of contrast-enhanced ultrasonography, CT-enhancement and MRI in the diagnosis of liver-occupying lesions. METHODS: 176 patients with suspected liver lesions in our hospital were retrospectively studied from July 2014 to July 2016. All of the 176 patients were diagnosed by contrast-enhanced ultrasonography, enhanced CT and MRI, and the pathological examination was performed. The results of pathological examination were regarded as the results of the diagnosis. The diagnostic accuracywas then compared among contrast-enhanced ultrasound, enhanced CT and MRI of these patients. RESULTS: The results of contrast-enhanced ultrasonography showed that 164 of the 176 patients had liver-occupying lesions, and the accuracy of the diagnosis was 95.35%, which was significantly higher than that of CT enhancement and MRI (80.23% 84.30%). The accuracy of contrast-enhanced ultrasonography, in the diagnosis of primary liver cancer was significantly higher than that of CT enhancement and MRI (P < 0.05), and the difference was significant difference (P < 0.05). CONCLUSIONS: The examination of contrast-enhanced ultrasonography is relatively simple, and the patients can get duplicateexamination, so we should choose the contrast-enhanced ultrasonography as the preferred method of diagnosis in liver mass, especially primary liver cancer.

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CT attenuation of normal liver parenchyma on delayed scanning with iohexol

Acta Radiologica ◽

10.3109/02841859209172046 ◽

1992 ◽

Vol 33 (5) ◽

pp. 502-503

Author(s):

G. Tidebrant ◽

P. Lukes ◽

A. Wihed

Keyword(s):

Normal Liver ◽

Liver Parenchyma ◽

Normal Liver Parenchyma ◽

Ct Attenuation

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Contrast-enhanced ultrasonography features of hepatobiliary neoplasms in cats

Veterinary Record ◽

10.1136/vr.105453 ◽

2019 ◽

Vol 186 (10) ◽

pp. 320-320 ◽

Cited By ~ 2

Author(s):

Tommaso Banzato ◽

Silvia Burti ◽

Giuseppe Rubini ◽

Riccardo Orlandi ◽

Paolo Bargellini ◽

...

Keyword(s):

Bile Duct ◽

Diagnostic Accuracy ◽

Large Range ◽

Liver Parenchyma ◽

Qualitative And Quantitative ◽

Hepatocellular Carcinomas ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Malignant Lesions

BackgroundContrast-enhanced ultrasonography (CEUS) features of primary hepatobiliary neoplasms have been reported in dogs but no information is available in cats.MethodsQualitative and quantitative features of bile duct adenomas (BDAs, n=20), bile duct carcinomas (BDCs, n=16), and hepatocellular carcinomas (HCCs, n=8) are described in 44 cats.ResultsThere was an overlap in CEUS qualitative features between different histotypes, both in wash-in and wash-out phases. Distinction between different neoplasms based only on the CEUS qualitative features was not possible. At peak of enhancement, the BDAs, BDCs and HCCs showed a large range of echogenicities, from hypoenhancement to hyperenhancement, in comparison to the liver parenchyma. Eight of 20 BDAs showed inhomogeneous hyperenhancement during wash-in, which is a feature reported as typical of malignant lesions in dogs. BDC had a significantly faster wash-in compared with both BDA and HCC but the diagnostic accuracy of all the included quantitative variables was only moderate. No significant differences in the wash-out quantitative features of BDA and BDC were evident.ConclusionThere is poor evidence that CEUS may be used to distinguish between different primary hepatobiliary neoplasms in cats.

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904 Evaluation Through FibroScan and Contrast Enhanced Ultrasound (CEUS) of Liver Stiffness and Liver Parenchyma Blood Flow in Non Alcoholic Fatty Liver Disease (NAFLD), Chronic Hepatitis C (CHC) Without Cirrhosis vs Normal Controls

Gastroenterology ◽

10.1016/s0016-5085(15)30569-2 ◽

2015 ◽

Vol 148 (4) ◽

pp. S-170-S-171

Author(s):

Sila Cocciolillo ◽

Ada Maria Di Tullio ◽

Mauro Pagliaro ◽

Roberta Tavani ◽

Massimiliano di Berardino ◽

...

Keyword(s):

Blood Flow ◽

Chronic Hepatitis ◽

Fatty Liver Disease ◽

Liver Stiffness ◽

Liver Parenchyma ◽

Contrast Enhanced Ultrasound ◽

Alcoholic Fatty Liver ◽

Contrast Enhanced ◽

Alcoholic Fatty Liver Disease ◽

Normal Controls

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Evaluation of Hemodynamics in Focal Steatosis and Focal Spared Lesion of the Liver Using Contrast-Enhanced Ultrasonography with Sonazoid

Radiology Research and Practice ◽

10.1155/2014/604594 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Kazue Shiozawa ◽

Manabu Watanabe ◽

Takashi Ikehara ◽

Michio Kogame ◽

Mie Shinohara ◽

...

Keyword(s):

Fatty Liver ◽

Real Time ◽

Liver Parenchyma ◽

Target Lesion ◽

Invasive Procedures ◽

Enhancement Pattern ◽

The Third ◽

Fat Deposits ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography

We aim to investigate the hemodynamics in focal steatosis and focal spared lesion of the liver using contrast-enhanced ultrasonography (CEUS) with Sonazoid. The subjects were 47 patients with focal steatosis and focal spared lesion. We evaluated enhancement patterns (hyperenhancement, isoenhancement, and hypoenhancement) in the vascular phase and the presence or absence of a hypoechoic area in the postvascular phase for these lesions using CEUS. Of the 24 patients with focal steatosis, the enhancement pattern was isoenhancement in 19 and hypoenhancement in 5. Hypoechoic areas were noted in the postvascular phase in 3 patients. Of the 23 patients with focal spared lesions, the enhancement pattern was isoenhancement in 18 and hyperenhancement in 5. No hypoechoic areas were noted in the postvascular phase in any patient. The hemodynamics in focal steatosis and focal spared lesions in nondiffuse fatty liver can be observed using low-invasive procedures in real-time by CEUS. It was suggested that differences in the dynamics of enhancement in the vascular phase of CEUS were influenced by the fat deposits in the target lesion, the surrounding liver parenchyma, and the third inflow.

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