scholarly journals Alterations of the Predominant Fecal Microbiota and Disruption of the Gut Mucosal Barrier in Patients with Early-Stage Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Xia Liu ◽  
Yiwen Cheng ◽  
Li Shao ◽  
Zongxin Ling
Keyword(s):  
Colorectal Cancer ◽  
Diamine Oxidase ◽  
Early Stage ◽  
Fusobacterium Nucleatum ◽  
Fecal Microbiota ◽  
Mucosal Barrier ◽  
Beneficial Bacteria ◽  
Barrier Dysfunction ◽  
Real Time Quantitative Pcr ◽  
Gut Mucosal Barrier

Growing evidence indicated that the gut microbiota was the intrinsic and essential component of the cancer microenvironment, which played vital roles in the development and progression of colorectal cancer (CRC). In our present study, we investigated the alterations of fecal abundant microbiota with real-time quantitative PCR and the changes of indicators of gut mucosal barrier from 53 early-stage CRC patients and 45 matched healthy controls. We found that the traditional beneficial bacteria such as Lactobacillus and Bifidobacterium decreased significantly and the carcinogenic bacteria such as Enterobacteriaceae and Fusobacterium nucleatum were significantly increased in CRC patients. We also found gut mucosal barrier dysfunction in CRC patients with increased levels of endotoxin (LPS), D-lactate, and diamine oxidase (DAO). With Pearson’s correlation analysis, D-lactate, LPS, and DAO were correlated negatively with Lactobacillus and Bifidobacterium and positively with Enterobacteriaceae and F. nucleatum. Our present study found dysbiosis of the fecal microbiota and dysfunction of the gut mucosal barrier in patients with early-stage CRC, which implicated that fecal abundant bacteria and gut mucosal barrier indicators could be used as targets to monitor the development and progression of CRC in a noninvasive and dynamic manner.

NOVEL HEMIGRAMICIDIN-TEMPO CONJUGATES AMELIORATE GUT MUCOSAL BARRIER DYSFUNCTION AND CASPASE-3/7 ACTIVATION IN RATS SUBJECTED TO HEMORRHAGIC SHOCK.

2005 ◽  
Vol 33 ◽  
pp. A32
Author(s):  
Carlos A Macias ◽  
Jeffrey W Chiao ◽  
Yulia Y Tyurina ◽  
Peter Wipf ◽  
Jingbo Xiao ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Caspase 3 ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier

scholarly journals Plasmadiafiltration ameliorating gut mucosal barrier dysfunction and improving survival in porcine sepsis models

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Ming Xin Li ◽  
Jun Feng Liu ◽  
Jian Da Lu ◽  
Ying Zhu ◽  
Ding Wei Kuang ◽  
...  
Keyword(s):  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier

scholarly journals FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Weiwei Liang ◽  
Xinjian Peng ◽  
Qingqing Li ◽  
Pingzhang Wang ◽  
Ping Lv ◽  
...  
Keyword(s):  
Fecal Microbiota ◽  
Mucosal Barrier ◽  
Chemically Induced ◽  
Normal Microbiota ◽  
Physiological Homeostasis ◽  
Gut Mucosal Barrier ◽  
Increased Sensitivity ◽  
Inflammatory Bowel ◽  
Genetic And Environmental Factors

AbstractThe physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer. Pretreatment of Fam3D−/− mice with antibiotics significantly reduces the severity of chemically induced colitis and wild type (WT) mice co-housed with Fam3D−/− mice phenocopy Fam3D-deficiency showing increased sensitivity to colitis and skewed composition of fecal microbiota. An initial equilibrium of microbiota in cohoused WT and Fam3D−/− mice is followed by an increasing divergence of the bacterial composition after separation. These results demonstrate the essential role of Fam3D in colon homeostasis, protection against inflammation associated cancer and normal microbiota composition.

scholarly journals Probiotic pretreatment improves survival and prevents gut mucosal barrier dysfunction in sepsis

Critical Care ◽  
2014 ◽  
Vol 18 (S2) ◽  
Author(s):  
KL Calisto ◽  
ACAP Camacho ◽  
FC Mittestainer ◽  
MCS Mendes ◽  
AC Santos ◽  
...  
Keyword(s):  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier

Colorectal Cancer, Gut Microbiota and Traditional Chinese Medicine: A Systematic Review

2021 ◽  
pp. 1-24
Author(s):  
Hui Zhao ◽  
Man He ◽  
Meng Zhang ◽  
Qiang Sun ◽  
Sha Zeng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Microbial Colonization ◽  
Mucosal Barrier ◽  
Cancer Genes ◽  
Barrier Dysfunction ◽  
Herbal Compound ◽  
Chinese Herbal Compound

Based on the study and research on the pathogenesis of colorectal cancer, the types and functions of gut microbiota, and its role in guiding and regulating the occurrence and development of diseases, we have explored the mechanism of traditional Chinese medicine in the treatment of colorectal cancer by regulating the gut microbiota. Genetic variation, abnormal responses of innate and adaptive immunity, mucosal barrier dysfunction, imbalance of intestinal microbial colonization, personal and environmental risk factors are the main pathogenesis of colorectal cancer. The gut microbiota mainly includes Sclerotium (including Clostridium, Enterococcus, Lactobacillus and Ruminococcus) and Bacteroides (including Bacteroides and Prevotella), which have biological antagonism, nutrition for the organism, metabolic abilities, immune stimulation, and ability to shape cancer genes functions to body. The gut microbiota can be related to the health of the host. Current studies have shown that Chinese herbal compound, single medicinal materials, and monomer components can treat colorectal cancer by regulating the gut microbiota, such as Xiaoyaosan can increase the abundance of Bacteroides, Lactobacillus, and Proteus and decrease the abundance of Desulfovibrio and Rickerella. Therefore, studying the regulation and mechanism of gut microbiota on colorectal cancer is of great benefit to disease treatment.

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