NOVEL HEMIGRAMICIDIN-TEMPO CONJUGATES AMELIORATE GUT MUCOSAL BARRIER DYSFUNCTION AND CASPASE-3/7 ACTIVATION IN RATS SUBJECTED TO HEMORRHAGIC SHOCK.

2005 ◽  
Vol 33 ◽  
pp. A32
Author(s):  
Carlos A Macias ◽  
Jeffrey W Chiao ◽  
Yulia Y Tyurina ◽  
Peter Wipf ◽  
Jingbo Xiao ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Caspase 3 ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier

scholarly journals Gut Mucosal Barrier Dysfunction, Microbial Dysbiosis, and Their Role in HIV-1 Disease Progression

2016 ◽  
Vol 214 (suppl 2) ◽  
pp. S58-S66 ◽  
Author(s):  
Joseph C. Mudd ◽  
Jason M. Brenchley
Keyword(s):  
Disease Progression ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Microbial Dysbiosis ◽  
Gut Mucosal Barrier ◽  
Hiv 1

scholarly journals Alterations of the Predominant Fecal Microbiota and Disruption of the Gut Mucosal Barrier in Patients with Early-Stage Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Xia Liu ◽  
Yiwen Cheng ◽  
Li Shao ◽  
Zongxin Ling
Keyword(s):  
Colorectal Cancer ◽  
Diamine Oxidase ◽  
Early Stage ◽  
Fusobacterium Nucleatum ◽  
Fecal Microbiota ◽  
Mucosal Barrier ◽  
Beneficial Bacteria ◽  
Barrier Dysfunction ◽  
Real Time Quantitative Pcr ◽  
Gut Mucosal Barrier

Growing evidence indicated that the gut microbiota was the intrinsic and essential component of the cancer microenvironment, which played vital roles in the development and progression of colorectal cancer (CRC). In our present study, we investigated the alterations of fecal abundant microbiota with real-time quantitative PCR and the changes of indicators of gut mucosal barrier from 53 early-stage CRC patients and 45 matched healthy controls. We found that the traditional beneficial bacteria such as Lactobacillus and Bifidobacterium decreased significantly and the carcinogenic bacteria such as Enterobacteriaceae and Fusobacterium nucleatum were significantly increased in CRC patients. We also found gut mucosal barrier dysfunction in CRC patients with increased levels of endotoxin (LPS), D-lactate, and diamine oxidase (DAO). With Pearson’s correlation analysis, D-lactate, LPS, and DAO were correlated negatively with Lactobacillus and Bifidobacterium and positively with Enterobacteriaceae and F. nucleatum. Our present study found dysbiosis of the fecal microbiota and dysfunction of the gut mucosal barrier in patients with early-stage CRC, which implicated that fecal abundant bacteria and gut mucosal barrier indicators could be used as targets to monitor the development and progression of CRC in a noninvasive and dynamic manner.

Inhibition of inducible nitric oxide synthase ameliorates endotoxin- induced gut mucosal barrier dysfunction in rats

1997 ◽  
Vol 113 (4) ◽  
pp. 1246-1257 ◽  
Author(s):  
N Unno ◽  
H Wang ◽  
MJ Menconi ◽  
SH Tytgat ◽  
V Larkin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Plasmadiafiltration ameliorating gut mucosal barrier dysfunction and improving survival in porcine sepsis models

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Ming Xin Li ◽  
Jun Feng Liu ◽  
Jian Da Lu ◽  
Ying Zhu ◽  
Ding Wei Kuang ◽  
...  
Keyword(s):  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier

scholarly journals Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay

2007 ◽  
Vol 580 (1) ◽  
pp. 347-356 ◽  
Author(s):  
Frederick Barreau ◽  
Christel Cartier ◽  
Mathilde Leveque ◽  
Laurent Ferrier ◽  
Raphael Moriez ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Maternal Deprivation ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Adult Rats ◽  
Nerve Growth ◽  
Corticotrophin Releasing Factor ◽  
Gut Mucosal Barrier

scholarly journals Probiotic pretreatment improves survival and prevents gut mucosal barrier dysfunction in sepsis

Critical Care ◽  
2014 ◽  
Vol 18 (S2) ◽  
Author(s):  
KL Calisto ◽  
ACAP Camacho ◽  
FC Mittestainer ◽  
MCS Mendes ◽  
AC Santos ◽  
...  
Keyword(s):  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier

Methotrexate induces dose-dependent gut mucosal barrier dysfunction in an experimental animal model

2002 ◽  
Vol 171 (S1) ◽  
pp. 8-9
Author(s):  
J. Bingham ◽  
M. Scott ◽  
S. J. Kirk ◽  
K. R. Gardiner
Keyword(s):  
Animal Model ◽  
Experimental Animal ◽  
Experimental Animal Model ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Gut Mucosal Barrier ◽  
Dose Dependent

The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock

2006 ◽  
Vol 291 (4) ◽  
pp. G556-G565 ◽  
Author(s):  
Kathleen G. Raman ◽  
Penny L. Sappington ◽  
Runkuan Yang ◽  
Ryan M. Levy ◽  
Jose M. Prince ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Bacterial Translocation ◽  
Intestinal Barrier ◽  
High Plasma ◽  
Mucosal Barrier ◽  
Barrier Dysfunction ◽  
Mesenteric Lymph Nodes ◽  
Mucosal Permeability ◽  
Intestinal Barrier Dysfunction ◽  
Soluble Rage

The receptor for advanced glycation end products (RAGE) has been implicated in the pathogenesis of numerous conditions associated with excessive inflammation. To determine whether RAGE-dependent signaling is important in the development of intestinal barrier dysfunction after hemorrhagic shock and resuscitation (HS/R), C57Bl/6, rage−/−, or congenic rage+/+ mice were subjected to HS/R (mean arterial pressure of 25 mmHg for 3 h) or a sham procedure. Twenty-four hours later, bacterial translocation to mesenteric lymph nodes and ileal mucosal permeability to FITC-labeled dextran were assessed. Additionally, samples of ileum were obtained for immunofluorescence microscopy, and plasma was collected for measuring IL-6 and IL-10 levels. HS/R in C57Bl/6 mice was associated with increased bacterial translocation, ileal mucosal hyperpermeability, and high circulating levels of IL-6. All of these effects were prevented when C57Bl/6 mice were treated with recombinant human soluble RAGE (sRAGE; the extracellular ligand-binding domain of RAGE). HS/R induced bacterial translocation, ileal mucosal hyperpermeability, and high plasma IL-6 levels in rage+/+ but not rage−/− mice. Circulating IL-10 levels were higher in rage−/− compared with rage+/+ mice. These results suggest that activation of RAGE-dependent signaling is a key factor leading to gut mucosal barrier dysfunction after HS/R.

Sign in / Sign up

Export Citation Format

Share Document