scholarly journals Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Miaomiao Li ◽  
Zeqi Guo ◽  
Dan Zhang ◽  
Xiangbo Xu ◽  
Fernando Gomes Romeiro ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Liver Cirrhosis ◽  
Gastrointestinal Hemorrhage ◽  
Troponin T ◽  
Cardiac Biomarkers ◽  
Cardiac Markers ◽  
Cross Sectional ◽  
Ctnt Level ◽  
Creatine Kinase Mb ◽  
Cirrhotic Patients

Background and Aim. Liver cirrhosis is often accompanied by insidious cardiac dysfunction. This retrospective cross-sectional study is aimed at exploring the correlation between serum cardiac markers and decompensating events in liver cirrhosis. Methods. Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 were screened. Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH), were collected. Acute decompensating events at admission, primarily including ascites, acute gastrointestinal hemorrhage, and acute-on-chronic liver failure (ACLF), were recorded. Results. The NT-pro BNP level was significantly higher in cirrhotic patients with acute decompensating events than in those without any decompensating events (median: 140.75 pg/mL versus 41.86 pg/mL, P<0.001). The NT-pro BNP level significantly correlated with ascites, acute gastrointestinal hemorrhage, and ACLF. The hs-cTnT level was significantly higher in cirrhotic patients with acute decompensating events than in those without decompensating events (median: 0.008 ng/mL versus 0.006 ng/mL, P=0.007). The hs-cTnT level significantly correlated with acute gastrointestinal hemorrhage, but not ascites or ACLF. LDH (185.0 U/L versus 173.5 U/L, P=0.281), CK (71 U/L versus 84 U/L, P=0.157), and CK-MB (29.5 U/L versus 33.0 U/L, P=0.604) levels were not significantly different between cirrhotic patients with and without acute decompensating events. Conclusion. The elevated NT-pro BNP level seems to be closely related to the development of acute decompensating events in liver cirrhosis.

scholarly journals Automatizáltan mérhető biomarkerek az akut myocardialis infarctus diagnosztikájában

2015 ◽  
Vol 156 (24) ◽  
pp. 964-971
Author(s):  
Ferenc Kovács ◽  
Ibolya Kocsis ◽  
Marina Varga ◽  
Enikő Sárváry ◽  
György Bicsák
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Troponin I ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Biomarkers ◽  
Fatty Acid Binding ◽  
High Sensitivity Troponin ◽  
Creatine Kinase Mb

Introduction: Cardiac biomarkers have a prominent role in the diagnosis of acute myocardial infarction. Aim: The aim of the authors was to study the diagnostic effectiveness of automated measurement of cardiac biomarkers. Method: Myeloperoxidase, high-sensitivity C-reactive protein, myoglobin, heart-type fatty acid binding protein, creatine kinase, creatine kinase MB, high-sensitivity troponin I and T were measured. Results: The high-sensitivity troponin I was the most effective (area under curve: 0.86; 95% confidence interval: 0.77–0.95; p<0.001) for the diagnosis of acute myocardial infarction. Considering a critical value of 0.35 ng/mL, its sensitivity and specificity were 81%, and 74%, respectively. Combined evaluation of the high-sensitivity troponin T and I, chest pain, and the electrocardiogram gave the best results for separation of acute myocardial infarction from other diseases (correct classification in 62.5% and 98.9% of patients, respectively). Conclusions: Until a more sensitive and specific cardiac biomarker becomes available, the best method for the diagnosis of acute myocardial infarction is to evaluate electrocardiogram and biomarker concentration and to repeat them after 3–6 hours. Orv. Hetil., 2015, 156(24), 964–971.

Plasma or serum samples: measurements of cardiac troponin T and of other analytes compared

2004 ◽  
Vol 42 (8) ◽  
Author(s):  
Roberto Dominici ◽  
Ilenia Infusino ◽  
Cristina Valente ◽  
Irene Moraschinelli ◽  
Carlo Franzini
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Cardiac Markers ◽  
Serum Samples ◽  
Cardiac Marker ◽  
Creatine Kinase Mb ◽  
Heparin Plasma ◽  
Automated Methods

AbstractConflicting data in the literature concern possible differences in the immunochemical measurement of cardiac troponins, either in plasma or in serum. In order to address this specific point, 96 serum and heparin-plasma pairs were obtained for cardiac marker measurement [cardiac troponin T (cTnT); myoglobin (Myo) and creatine kinase-MB isoenzyme (CK-MB)]; 29 additional “common” analytes were measured in 77 such samples. The cardiac markers were measured by electrochemiluminescence (Elecsys 2010, Roche); the other analytes by established automated methods (Modular, Roche). Mean plasma/serum ratios for cTnT (0.95), creatine kinase-MB (1.01) and myoglobin (0.99) were comparable with those of the 29 common analytes (interval of means 0.83–1.05). The distribution of the plasma-serum differences also showed similarities between cardiac markers and other analytes. A few outlier plasma-serum differences (3–5%) were measured for both categories of analytes. Addition of heparin to serum (51 samples) caused decreased cTnT (mean ratio 0.92). In 3 of 51 such samples the cTnT decrease was more marked, but in a second sample from the same subjects (1 week later) such a prominent, heparin-induced loss of cTnT no longer appeared. In conclusion, plasma-serum differences in immuno-reactive cTnT compare with those observed for other analytes. In occasional heparin-plasma samples immunochemical measurement of cTnT may give exceptionally low values. However, in our sample group of 96 patients (cTnT lower or higher than the cut-off in, respectively, 24 and 72 patients), no misclassification occurred if plasma instead of serum cTnT values were considered.

scholarly journals Isolation and Quantification of Nanovesicles in Isoproterenol-Induced Myocardial Infarcted Rats

2018 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Histopathological Analysis ◽  
Specific Marker ◽  
Cardiac Markers ◽  
Creatine Kinase Mb ◽  
Group A ◽  
Group B

Introduction and Aim: Myocardial infarction (MI) is one of the leading causes of death worldwide. The pathogenesis and aetiology of MI is still unclear and there is currently no cure for MI. Cardiac troponin is the only well-known cardiac-specific marker for the diagnosis of MI but due to the delayed release of troponin in the circulation, a novel cardiac biomarker is needed in the early stages of development of MI to reduce MI mortality. Recently, it has been reported that exosome concentration is highly regulated by stress and cardiovascular diseases (CVDs). We assessed the hypothesis that exosome secretion by the injured cardiomyocytes is increased during MI and thereby serve as biomarker for MI. The aim of this study was to quantify exosomes in an isoproterenol (ISO)-induced MI rats. Method: Twelve rats were divided into two groups (group A and B). Group-A (n=6) was the normal control rats and group-B (n=6) was the ISO-treated group. Group-B animals were injected with isoproterenol (85mg/kg/bw) for two consecutive days to induce MI. Blood pressure (BP), heart rate (HR) and body weight were monitored for 7 days in all animals prior the ISO injection and throughout the experiment. After second ISO-injection, all animals were sacrificed and blood, heart tissues were obtained. Histopathological analysis was performed in heart tissue samples and levels of cardiac markers (creatine kinase-MB, lactate dehydrogenase and troponin T) were measured from the serum. Exosomes were isolated from the plasma by differential ultracentrifugation. Exosomes were quantified and characterized using nanoparticle tracking analysis (NTA), transmission electron microscope (TEM) study and ELISA for the quantification of circulating exosomal protein (CD63). Result and Discussion: ISO injection caused the development of MI and was confirmed by the increase in BP, Cardiac markers (cardiac troponin T, lactate dehydrogenase and creatine kinase). NTA together with TEM analysis revealed particle sizes of the exosome and showed an elevated number of the exosome in ISO-treated animals. Levels of exosomal protein (CD63) were also increased in ISO-treated animals. Conclusion: The concentration of exosomes was increased in MI rats indicating that circulating exosomes may be used as a novel diagnostic marker for MI.

scholarly journals HOMOCYSTEINE: A NEWER AND NOVEL INDEPENDENT RISK FACTOR AND CARDIAC MARKER FOR ACUTE MI

2019 ◽  
pp. 177-180
Author(s):  
ANOOP KUMAR ◽  
PREETI SHARMA ◽  
PRADEEP KUMAR ◽  
DR ASHOK KUMAR
Keyword(s):  
Troponin T ◽  
Cross Sectional Study ◽  
Mean Value ◽  
Cardiac Markers ◽  
Negative Group ◽  
Cross Sectional ◽  
Positive Group ◽  
Creatine Kinase Mb ◽  
The Mean ◽  
The Difference

Objective: The objective of this study was to estimate homocysteine levels in myocardial infarction (MI) patients (troponin-T positive) and normal healthy individuals (troponin-T negative) subsequently to make comparisons with other cardiac markers. Methods: A cross-sectional study consisting of 172 subjects involving 100 patients of non-diabetic MI and 72 apparently healthy controls with no history of diabetes and/or MI was done between December 2017 and May 2018. The diagnosis of MI was established with electrocardiogram findings and troponin-T estimation. Blood samples were collected and processed for the estimation of homocysteine, troponin-T, creatine kinase MB fraction (CK-MB), and lactate dehydrogenase. Results: In the present study, a total of 100 troponin-T positive cases and 72 troponin-T negative as controls were studied. The mean age in the cases was 62.15±7.75 years and in the controls was 61.49±8.35 years (p=0.592). The mean value of homocysteine in the troponin-T positive group was 30.56±19.79 μmol/l and in the troponin-T negative group was 10.28±4.03 μmol/l (p<0.0001). Homocysteine was deranged in 98% troponin-T positive group and in only 18.06% in troponin-T negative group. The difference was statistically significant (p<0.0001). No significant correlation was found between homocysteine and CK-MB and LDH in troponin-T positive and negative patients individually. Conclusion: This study indicated that homocysteine is sensitive cardiac markers for the diagnosis of MI but shows no specific correlation with other cardiac markers and thus it should be predicted independently.

Serum Cardiac Troponin T and Creatine Kinase–MB Elevations in Murine Autoimmune Myocarditis

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1927-1932 ◽  
Author(s):  
Kurt Bachmaier ◽  
Johannes Mair ◽  
Felix Offner ◽  
Christian Pummerer ◽  
Nikolaus Neu
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Autoimmune Myocarditis ◽  
Creatine Kinase Mb ◽  
Serum Cardiac Troponin

Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery

2012 ◽  
Vol 164 (5) ◽  
pp. 779-785 ◽  
Author(s):  
Camilla Lund Søraas ◽  
Charlotte Friis ◽  
Kristin Victoria Tunheim Engebretsen ◽  
Leiv Sandvik ◽  
Sverre Erik Kjeldsen ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Troponin T ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Creatine Kinase Mb ◽  
Long Term Mortality

scholarly journals The magnitude and correlates of esophageal Varices among newly diagnosed cirrhotic patients undergoing screening fibre optic endoscope before incident bleeding in North-Western Tanzania; a cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Daniel W. Gunda ◽  
Semvua B. Kilonzo ◽  
Zakhia Mamballah ◽  
Paulina M. Manyiri ◽  
David C. Majinge ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Esophageal Varices ◽  
Clinical Laboratory ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Clinical Predictors ◽  
Endoscopic Screening ◽  
Cross Sectional ◽  
Northwestern Tanzania ◽  
Cirrhotic Patients

Abstract Background Bleeding esophageal varices is a deadly complication of liver cirrhosis. Guidelines recommend an early diagnosis of esophageal varices before incident bleeding by screening all patients diagnosed with liver cirrhosis. Though it has been reported elsewhere that the presence of esophageal varices varies widely among cirrhotic patients this has not been assessed in Tanzania since endoscopy is not readily available for routine use in our setting. This study was designed to determine the prevalence of esophageal varices and assess the utility of clinical parameters in predicting the presence of varices among cirrhotic patients in northwestern Tanzania. Methods A cross-sectional analysis of adult patients with liver cirrhosis was done at Bugando Medical Centre. Demographic, clinical, laboratory and endoscopic data were collected and analyzed using STATA 13. The presence of esophageal varices was detected using endoscopic examination and associated factors were assessed by logistic regression. The predictive value of clinical predictors was also assessed by calculating sensitivity and specificity. Results A total of 223 patients were enrolled, where 88 (39.5%; 95%CI: 33.0–45.9) had esophageal varices. The varices were independently associated with increased age (OR: 1.02; 95%CI: 1.0–1.04; p = 0.030); increased splenic diameter (OR:1.3; 95%CI:1.2–1.5; p <  0.001), increased portal vein diameter (OR:1.2; 95%CI: 1.07–1.4; p = 0.003), having ascites (OR: 3.0; 95%CI: 1.01–8.7; p = 0.046), and advanced liver disease (OR: 2.9; 95%CI: 1.3–6.7; p = 0.008). PSDR least performed in predicting varices, (AUC: 0.382; 95%CI: 0.304–0.459; cutoff: < 640; Sensitivity: 58.0%; 95%CI: 46.9–68.4; specificity: 57.0%; 95%CI: 48.2–65.5). SPD had better prediction; (AUC: 0.713; 95%CI: 0.646–0.781; cut off: > 15.2 cm; sensitivity: 65.9%; (95% CI: 55–75.7 and specificity:65.2%; 95%CI: 56.5–73.2), followed by PVD, (AUC: 0.6392; 95%CI: 0.566–0.712;cutoff: > 1.45 cm; sensitivity: 62.5%; 95CI: 51.5–72.6; specificity: 61.5%; 95%CI: 52.7–69.7). Conclusion Esophageal varices were prevalent among cirrhotic patients, most of which were at risk of bleeding. The non-invasive prediction of varices was not strong enough to replace endoscopic diagnosis. However, the predictors in this study can potentially assist in the selection of patients at high risk of having varices and prioritize them for endoscopic screening and appropriate management.

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