scholarly journals A Higher Serum Anion Gap Is Associated with the Risk of Progressing to Impaired Fasting Glucose and Diabetes

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yingchao Zhang ◽  
Fengran Xiong ◽  
Ruxuan Zhao ◽  
Tingting Shi ◽  
Jing Lu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Impaired Fasting Glucose ◽  
Roc Curve ◽  
Fasting Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Population Based ◽  
Anion Gap ◽  
Plasma Metabolites ◽  
History Of

Impaired fasting glucose (IFG) is a reversible intermediate hyperglycemia stage with an increasing risk of diabetes and related complications. Our study was designed to identify the relationship between the serum anion gap and the risk of progressing to impaired fasting glucose and diabetes. Here, we performed a prospective, population-based study among 1191 Chinese individuals aged 22–87 years who took health examinations annually between 2006 and 2012 including clinical features and plasma metabolites. All of the participants had no history of diabetes or related chronic complications. Logistic regression analysis was designed to examine the associations between clinical and metabolomic factors and the risk of developing IFG or diabetes. Among them, 58 subjects whose fasting glucose were between 6.1 and 7 mmol/L were diagnosed as IFG or diabetes. After adjusting for age, sex, body mass index (BMI), high-density lipoprotein (HDL), low-density lipoprotein (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), systolic blood pressure (SBP), diastolic blood pressure (DBP), potassium, and albumin at baseline, the participants in the upper tertiles of serum anion gap (SAG) had higher odds of progressing to IFG or diabetes than those in the lower tertiles. A receiver operating characteristic (ROC) curve was analyzed, and the optimal cutoff level for the anion gap to predict incident IFG or diabetes was 13.76 mmol/L, and the area under the ROC curve (AUC) was 0.623. Our data demonstrate that a higher serum anion gap is associated with the risk of developing IFG or diabetes.

scholarly journals A Higher Serum Anion Gap is Associated with the Risk of Progressing to Impaired Fasting Glucose and Diabetes

2021 ◽  
Author(s):  
Yingchao Zhang ◽  
Fengran Xiong ◽  
Ruxuan Zhao ◽  
Tingting Shi ◽  
Jin-Kui Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Impaired Fasting Glucose ◽  
Roc Curve ◽  
Fasting Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Population Based ◽  
Anion Gap ◽  
Plasma Metabolites ◽  
Roc Curve Analysis

Abstract Backgound Impaired fasting glucose (IFG) is an invertible interim hyperglycemia period with an increasing risk of diabetes and related complications. Our study was designed to identify that the serum anion gap is related to the risk of progressing to IFG and diabetes. Methods We performed a prospective, population-based study among 1191 Chinese individuals aged 22-87 years who taken health examinations annually between 2006 and 2012 including clinical features and plasma metabolites. All of the participants had no history of diabetes or related chronic complications. We designed logistic regression analysis to examine the associations between clinical and metabolomic factors and the risk of developing to IFG or diabetes. Results Among them, 58 subjects whose fasting glucose were between 6.1 and 7 mmol/L were diagnosed as IFG or diabetes. After adjusting for age, gender, body mass index (BMI), low-density lipoprotein (LDL), high-density lipoprotein (HDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), systolic blood pressure (SBP), diastolic blood pressure (DBP), potassium and albumin at baseline, the participants in the upper tertiles of serum anion gap (SAG) are more likely to progress to IFG or diabetes than those in the lower tertiles. Receiver operating characteristic (ROC) curve analysis was used to predict incidence of IFG or diabetes. We found the optimal cutoff level for the anion gap was 13.76 mmol/L and the AUC (area under ROC curve) was 0.623. Conclusions Our data demonstrate that a higher SAG is associated with the risk of developing IFG or diabetes.

scholarly journals A higher serum anion gap is associated with the risk of progressing to impaired fasting glucose and diabetes

2021 ◽  
Author(s):  
Yingchao Zhang ◽  
Fengran Xiong ◽  
Ruxuan Zhao ◽  
Tingting Shi ◽  
Jing Lu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Impaired Fasting Glucose ◽  
Roc Curve ◽  
Fasting Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Population Based ◽  
Anion Gap ◽  
Roc Curve Analysis ◽  
Area Under Roc Curve

Abstract Impaired fasting glucose (IFG) is a reversible interim hyperglycemic period in which there is an increasing risk of developing diabetes and related complications. Our study aimed to identify that serum anion gap is related to the risk of IFG and diabetes development. We performed a prospective, population-based study among 1191 Chinese individuals aged 22–87 years who underwent health examinations annually between 2006 and 2012 including determining clinical biochemistry and plasma metabolite parameters. All the participants had no history of diabetes or related chronic complications. We performed logistic regression analysis to examine the association between clinical and metabolomic factors and the risk of developing IFG or diabetes. Among them, 58 subjects whose fasting glucose level was between 6.1 and 7 mmol/L were diagnosed with IFG or diabetes. After adjusting for age, sex, body mass index (BMI), low-density lipoprotein (LDL), high-density lipoprotein (HDL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, systolic blood pressure (SBP), diastolic blood pressure (DBP), potassium and albumin(ALB) levels at baseline, the participants in the upper tertiles of serum anion gap (SAG) were more likely to develop IFG or diabetes than those in the lower tertiles. Receiver operating characteristic (ROC) curve analysis was used to predict the incidence of IFG or diabetes. We found the optimal cutoff level for the anion gap was 13.76 mmol/L and the AUC (area under ROC curve) was 0.623. Our data demonstrates that a higher SAG is associated with the risk of developing IFG or diabetes.

Haemostatic, Endothelial and Lipoprotein Parameters and Blood Pressure Levels in Women with a History of Preeclampsia

1999 ◽  
Vol 81 (04) ◽  
pp. 538-542 ◽  
Author(s):  
Shu He ◽  
Angela Silveira ◽  
Anders Hamsten ◽  
Margareta Blombäck ◽  
Katarina Bremme
Keyword(s):  
Blood Pressure ◽  
Low Density Lipoprotein ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Normal Pregnancy ◽  
Index Pregnancy ◽  
History Of ◽  
Von Willebrand ◽  
Willebrand Factor

SummaryTo determine whether perturbations of haemostatic function and lipoprotein metabolism prevail long after preeclampsia and increase the risk of future coronary heart disease (CHD), we conducted a follow-up study in women with (cases, n = 25) or without (controls, n = 24) a history of preeclampsia. Blood samples were taken in the follicular and in the luteal phases of a menstrual cycle. Levels of blood pressure (BP) and proteinuria measured during the index pregnancy were included in the evaluation. Compared to control women who had undergone a normal pregnancy, the formerly preeclamptic patients had higher systolic (p <0.01) and diastolic (p <0.05) BPs and increased plasma levels of von Willebrand factor (vWF), fibrinogen, cholesterol, triglycerides and very low density lipoprotein (VLDL) (all p <0.05). The lipid, vWF, and fibrinogen levels were positively related to the degree of BP elevation but not to the degree of proteinuria during the index pregnancy. Except for the increase in vWF level, all biochemical perturbations were only present in the luteal but not in the follicular phase samples. In conclusion, persistent endothelial dysfunction with ensuing dysregulation of blood pressure, haemostatic perturbation and dyslipoproteinemia after preeclampsia may indicate a proneness to future CHD.

scholarly journals The Effect of Kelulut Honey on Fasting Blood Glucose and Metabolic Parameters in Patients with Impaired Fasting Glucose

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Mohd Radzniwan Rashid ◽  
Khairun Nain Nor Aripin ◽  
Fathima Begum Syed Mohideen ◽  
Nizam Baharom ◽  
Khairani Omar ◽  
...  
Keyword(s):  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Daily Intake ◽  
Density Lipoprotein ◽  
Metabolic Parameters ◽  
Control Group ◽  
Significant Difference ◽  
Group Control Group

Background. Impaired fasting glucose (IFG) poses a higher risk of diabetes. Honey has been reported to improve metabolic abnormalities including lowering hyperglycemia. This study is sought at determining the effect of Malaysian Kelulut honey (KH) on fasting glucose levels and metabolic parameters in IFG patients. Methods. This quasi-experimental intervention study of 30-day duration was conducted among 60 adult patients with IFG. They were allocated into taking 30 g/day KH group (experimental group, n=30) and not taking KH group (control group, n=30). Body mass index (BMI), waist circumference, blood pressure (BP), fasting glucose, and lipid profile levels (total cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein) were measured before and after treatment. Results. There was no significant difference in all measured variables at day 30 compared to day 1 within both groups. Similarly, all measured variables neither at day 1 nor at day 30 had shown a statistically significant difference between the groups. Conclusions. Daily intake of 30 g KH for 30 days resulted in insignificant effect on fasting glucose, fasting lipid profiles, and other metabolic parameters in patients with IFG. Further studies that employ longer study duration are needed to ascertain the finding.

scholarly journals Utility Of Finnish Diabetes Risk Score In A Young Adult Population In An Urban Setting In Africa

2019 ◽  
Author(s):  
EVANGELISTA KENAN MALINDISA ◽  
Emmanuel Balandya ◽  
Fredirick Mashili ◽  
Marina Njelekela
Keyword(s):  
Blood Pressure ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Urban Setting ◽  
Screening Tools ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
History Of ◽  
Diabetes Risk Score

Abstract Background The prevalence of type 2 diabetes mellitus (T2D) and other NCDs is on the rise globally, low-income countries like Tanzania are not spared. Affordable and effective screening tools are needed to combat these epidemics. This study aimed to evaluate the utility and applicability of the Finnish Diabetes Risk Score (FINDRISC) as one of the screening tools for T2D and its potential risk factors in population of young adults from an urban setting in Tanzania. Methods A community based cross-sectional study was conducted in urban setting Mwanza-Tanzania. Data was collected using FINDRISC questionnaire (assessing Age, BMI, waist circumference, physical activity participation, vegetable consumption, and history of high blood pressure, history of high blood sugar and family history of diabetes) and physical assessment of, blood pressure, waist circumference and hip circumference. Laboratory measurements for fasting blood glucose, oral glucose tolerance and lipid profile. Data was analyzed using STATA 13. Pearson’s correlation was used to assess the associations between FINDRISC with clinical and biochemical parameters. Linear regression was used to assess the extent at which FINDRISC predicted various clinical and biochemical parameters. P-value was considered significant at p≤0.05. Results Of the 259 participants enrolled, 32.8% were in the FINDRISC categories of “at least slightly elevated risk” to “high risk” of developing T2D in 10 years’ time. FINDRISC correlated with FBG (r=0.12, p=0.05), diastolic blood pressure (r=0.19, p=0.02), mean arterial blood pressure (r=0.13, p=0.036), low density lipoprotein cholesterol (r=0.19, p =0.005), and waist to hip ratio - WHR (r=0.34, p = 0.001). Furthermore, FINDRISC explained 11% of the variation in WHR (Adjusted r2 = 0.11, p=0.001), 3% of diastolic blood pressure (adjusted r2= 0.03, p = 0.02), 3% of low density lipoprotein cholesterol (adjusted r2=0.03, p=0.005), 1% of mean arterial pressure (adjusted r2=0.01, p=0.036) and 1% of FBG (r2=0.01, p=0.05). Conclusion This study provides novel insights on the potential utility of FINDRISC as a simple and non-invasive screening tool for metabolic syndrome-related ailments among young adults in Africa. Longitudinal studies, with context-specific modifications of FINDRISC, are suggested to ascertain its predictive value for future T2D in this population.

scholarly journals Study on Reference Range of Zinc, Copper and Copper/Zinc Ratio in Childbearing Women of China

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 946
Author(s):  
Huidi Zhang ◽  
Yang Cao ◽  
Qingqing Man ◽  
Yuqian Li ◽  
Jiaxi Lu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Whole Blood ◽  
Reference Range ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Reference Value ◽  
Biological Indicators ◽  
Population Based ◽  
Essential Elements ◽  
Childbearing Women

Background: Copper and zinc are both essential elements in humans, that play various biological roles in body functions. Population-based reference values have not yet been established in China especially in childbearing women. The aim of this study is to establish a reference value of Zn, Cu and Cu/Zn ratios in childbearing women aged 18–44 from a representative population in China. Method: A total of 191 healthy childbearing women aged 18–44 years old were enrolled from the China Adult Chronic Disease and Nutrition Surveillance (2015) in this study with a series strict inclusion criteria. Basic biological indicators (weight, height, waist, blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein, total cholesterol, triglyceride, fast glycose, HbA1c, blood pressure, uric acid) and elements levels in plasma and whole blood were collected. The 2.5th to 97.5th was used to represent the reference range of Cu, Zn and Cu/Zn ratio. Results: The reference range of Zn, Cu and Cu/Zn ratio in plasma were 70.46–177.53 µg/dL, 74.30–170.68 µg/dL and 0.54–1.68, respectively. The reference range of Zn, Cu and Cu/Zn ratios in whole blood were 402.49–738.05, 74.63–124.52 and 0.13–0.25 µg/dL, respectively. Conclusion: The reference range of Zn, Cu and Cu/Zn ratios in plasma and whole blood of healthy Chinese childbearing women could be used as an indicator to evaluate the status of element deficiency and overload.

The Effect of Rosuvastatin on Low-Density Lipoprotein Subfractions in Patients With Impaired Fasting Glucose

2014 ◽  
Vol 20 (3) ◽  
pp. 276-283 ◽  
Author(s):  
Christos V. Rizos ◽  
Michael S. Kostapanos ◽  
Evangelos C. Rizos ◽  
Alexandros D. Tselepis ◽  
Moses S. Elisaf
Keyword(s):  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Subfractions

High-Intensity Interval Training as a Tool for Counteracting Dyslipidemia in Women

2018 ◽  
Vol 39 (05) ◽  
pp. 397-406 ◽  
Author(s):  
Cristian Alvarez ◽  
Rodrigo Ramirez-Campillo ◽  
Cristian Martinez-Salazar ◽  
Angélica Castillo ◽  
Francisco Gallardo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Intensity ◽  
Fasting Glucose ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Interval Training ◽  
Endurance Performance ◽  
High Intensity Interval Training ◽  
Adult Age ◽  
High Intensity Interval

AbstractSedentary overweight or obese adult (age<60 years) women, allocated in type 2 diabetes mellitus (T2DM, n=13), dyslipidemia alone (DYS, n=12), dyslipidemia associated with hyperglycaemia (DYSHG, N=12), or healthy control (CON, n=10) groups, had their lipid, glucose, blood pressure, endurance performance, and anthropometry variables assessed before and after 16 weeks of a thrice-weekly high-intensity interval training (HIIT) program. Triglycerides reduced significantly (P<0.05) in all groups, and high-density lipoprotein increased (P<0.01) in T2DM, DYS and DYSHG; however, low-density lipoprotein reduced (P<0.05) only in DYSHG, and total cholesterol reduced (P<0.01) only in DYS and DYSHG. Fasting glucose reduced (P<0.05) significantly in T2DM, DYS and DYSHG, but with higher decreases in T2DM and DYSHG. Blood pressure, endurance performance and body composition improved (P<0.05) in all groups. The HIIT program was effective for restoring lipid profile of DYS and DYSHG, and fasting glucose of DYSHG to levels similar to those of CON, with a weekly time commitment 25% to 56% lower than the minimum recommended in current exercise guidelines. These findings suggest that HIIT may be a time-efficient intervention for counteracting dyslipidemia.

Sign in / Sign up

Export Citation Format

Share Document