scholarly journals Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Marius Nicolae Popescu ◽  
Mădălina Gabriela Iliescu ◽  
Cristina Beiu ◽  
Liliana Gabriela Popa ◽  
Mara Mădălina Mihai ◽  
...  

Platelet-rich plasma (PRP) has emerged as a significant regenerative therapy used alone or combined mainly with stem cells, autologous fat grafts, hyaluronic acid, and biomaterials in a variety of medical fields, especially in hair regrowth, wound healing, and sports and rehabilitation medicine. However, the results obtained with this biologic therapy are heterogeneous and conflicting. The observed disparities in the effectiveness of PRP therapies may be due to a lack of standardization in blood processing and preparation. This article is aimed at reviewing the main biological parameters that need to be documented for a thorough reporting of quantitative and qualitative characteristics of the PRP injected, to allow a comparison between the quality of samples and the clinically obtained results and advance the efforts towards treatment standardization.

2017 ◽  
Vol 28 (3) ◽  
pp. e299-e302 ◽  
Author(s):  
Ihsan Kuzucu ◽  
Guclu Kaan Beriat ◽  
Hande Ezerarslan ◽  
Sedat Ozdemir ◽  
Sinan Kocaturk

Author(s):  
S.Tina Roshini ◽  
A. Arunprasad ◽  
B.Justin William ◽  
K. Jeyaraja ◽  
K. Priyadharshini

Digital flexor tendon injuries are the most common cause of early retirement and economic loss in the equine industry due to the poor healing tendency of the tendons. This study was conducted to improve the quality of tendon healing by using Autologous Platelet Rich Plasma incorporated collagen scaffold. Using ultrasound guidance, autologous Platelet Rich Plasma with and without collagen scaffold was engrafted intra-lesionally into 12 affected digital flexor tendons of 11 horses and healing was assessed periodically. Lameness score decreased in all the horses and the therapeutic outcome of intra-lesional engraftment of Autologous Platelet Rich Plasma with collagen scaffold was found to be superior in terms of clinical outcome, ultrasonographic and biochemical assessment. Ultrasonography served as an effective tool for diagnosis and for evaluation of healing tendon injuries.


Retos ◽  
2021 ◽  
pp. 209-213
Author(s):  
Lina Andrea Gomez ◽  
Javier Fernando Bonilla Briceño ◽  
Angélica Patricia Martinez Vasquez ◽  
Ana Luisa Muñoz

  Platelet-rich plasma (PRP) is a platelet concentrate that is obtained after centrifugation and may influence tissues healing by growth factors released after platelet degranulation. This treatment has been used for the management of muscles, ligaments, and tendinopathy injuries with promising results, there is still limited clinical evidence for its use. In this study we present the report of a case of a 50-year-old soccer player who presented an injury at the origin of the ischeotibial muscles of the right thigh. On day 13, after the injury, autologous Platelet Rich Plasma (APRP) was applied under ultrasound (US) guidance. The control by US and Nuclear Magnetic Resonance (NMR) was performed two weeks after the PPR application, which show resolution of the hematoma, and tissue regeneration. The patient returned to his sports activity at week 12 after the PRP treatment, without pain and with improvement in muscular strength The PRP treatment could be an option to avoid surgical procedures in athletes because it could improve muscular strength and healing, added it is easy to obtain and apply. Further studies are necessary to reach a consensus regarding clinical indications, processing and PRP application techniques that rebound in alternatives to improve the quality of life of patients in a cost-effective way, as well as shortening the recovery time of athletes.  Resumen. El plasma rico en plaquetas (PRP) es un concentrado de plaquetas que se obtiene después de centrifugación y puede influir en la curación de los tejidos por los factores de crecimiento liberados después de la desgranulación de las plaquetas. La terapia con PRP ha sido utilizada para el manejo de lesiones de tejidos blandos, como músculos, ligamentos y tendones con resultados prometedores. aunque la evidencia clínica actual para su uso es limitada. En este estudio presentamos el reporte del caso de un jugador de fútbol de 50 años que presentó lesión en el origen de la musculatura isquiotibial del muslo derecho. El día 13, después de la lesión, se le aplicó Plasma Rico en Plaquetas Autólogo (PRPA) guiado por ultrasonido (US). El control por US y resonancia magnética nuclear (RMN) se realizó dos semanas después de la aplicación del PRP, mostrando recuperación de la lesión y resolución del hematoma. El paciente volvió a realizar actividades deportivas en la semana 12 después del tratamiento, sin dolor y con mejoría de la fuerza muscular. El tratamiento con PRP podría ser una opción para evitar procedimientos quirúrgicos mejorando la fuerza muscular y la curación de la musculatura isqueotibial, adicionalmente el PRP es fácil de obtener y aplicar. De igual manera se necesitan más estudios para llegar a un consenso sobre las indicaciones clínicas, el procesamiento y las técnicas de aplicación de PRP que redunden en alternativas para mejorar la calidad de vida de los pacientes de una manera costo-efectiva, así como acortar el tiempo de recuperación de los atletas.


2020 ◽  
Vol 112 (2) ◽  
pp. 197-202
Author(s):  
Bruno M. Moroni ◽  
◽  
Juan P. Muñoz ◽  
Camila C. Battú ◽  
Pedro E. Straini ◽  
...  

A male patient with a diagnosis of steroid dependent inflammatory bowel disease (ulcerative colitis) sought medical care due to complex perianal fistula with extended chronic inflammation of the perianal region that was successfully treated with platelet-rich plasma as a single therapy. The benefits of autologous platelet-rich plasma for the treatment of this type of fistulas are presented. In this way, there is no need to perform surgery in a chronic inflammatory territory with high rate of complications and recurrence affecting patients’ quality of life.


2017 ◽  
Vol 49 (4) ◽  
pp. 573-580 ◽  
Author(s):  
Francesco Casabona ◽  
Ilaria Gambelli ◽  
Federica Casabona ◽  
Pierluigi Santi ◽  
Gregorio Santori ◽  
...  

Author(s):  
Madhan Jeyaraman ◽  
Ramesh R. ◽  
Prajwal G. S. ◽  
Hardik J. Dhamsania

<p class="abstract"><strong>Background:</strong> Adhesive capsulitis of should is also called frozen shoulder which describes a chronic, indolent pathological process in which the body forms excessive adhesions across the glenohumeral joint which in turn leads to pain, stiffness, and loss of range of movements which compromises the quality of life. The objective of the study was to evaluate the efficacy and functional outcome of autologous PRP injection and hydrodissection in adhesive capsulitis of shoulder.</p><p class="abstract"><strong>Methods:</strong> After excluding the patients who failed to satisfy the study protocol, the remaining 100 patients are divided equally into two groups namely group A (n=50) who receive autologous PRP injection and group B (n=50) who receive hydrodissection for adhesive capsulitis of shoulder. Both group participants are followed up pre-procedurally and post-procedurally at the end of 1<sup>st</sup>, 6<sup>th</sup> and 12<sup>th</sup> month for pain relief and range of movements. The improvements in pain and range of movements are charted in terms of VAS and DASH scoring system.<strong></strong></p><p class="abstract"><strong>Results:</strong> The statistical analysis were done for 46 patients in group A and 45 patients in group B which showed a statistical improvement in pain and range of movements (p&lt;0.001 for VAS score and p&lt;0.01 for DASH score) in group A who received autologous platelet rich plasma therapy. Autologous PRP therapy improves the functional quality of life with a long term outcome.</p><p class="abstract"><strong>Conclusions:</strong> For adhesive capsulitis of shoulder, autologous PRP therapy remains functionally superior than hydrodissection as autologous PRP is a constructive procedure by rejuvenating the degenerative tissues.</p><p> </p>


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