scholarly journals Efficacy of Sertraline Combined with Cognitive Behavioral Therapy for Adolescent Depression: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Wenliang Liu ◽  
Gongying Li ◽  
Congjie Wang ◽  
Xiuzhen Wang ◽  
Lin Yang
Keyword(s):  
Combination Therapy ◽  
Cognitive Behavioral Therapy ◽  
Scale Score ◽  
Adolescent Depression ◽  
Adverse Reactions ◽  
Rating Scale ◽  
Behavioral Therapy ◽  
Meta Analysis ◽  
Depression Score ◽  
Control Group

Objective. The efficacy of antidepressant drugs combined with psychotherapy is controversial; hence, this meta-analysis was conducted to assess the efficacy of the combination therapy. Methods. Relevant literature was searched in PubMed, Web of Science and Embase, Chinese databases CNKI, and WanFang Data. We included the literature on the comparison of the sertraline combined with cognitive behavioral therapy (CBT) and each treatment alone for adolescent depression published in 2000-2021. Meta-analysis was performed using Stata16.0 software. Results. A total of 421 relevant articles were retrieved, and 14 studies were finally included. In comparison with the control group (sertraline), sertraline combined with CBT achieved higher response rate ( OR = 5.07 , 95% CI: 3.00, 8.58) and lower incidence of adverse reactions ( OR = 0.43 , 95% CI: 0.24, 0.75). Before treatment, there were no significant differences in depression score, anxiety score, and symptom self-rating scale score between the two groups. After treatment, depression score ( SMD = − 2.79 , 95% CI: -3.64, -1.94), anxiety score ( SMD = − 1.22 , 95% CI: -1.96, -0.47), and symptom self-rating scale score ( SMD = − 1.73 , 95% CI: -3.19, -0.27) were significantly lower in the combined treatment group than in the control group. Conclusion. Although the number of comparative trials is small, this study shows that sertraline is effective for adolescent depression, but sertraline combined with CBT is more effective. The latter can significantly reduce the incidence of depressive symptoms, anxiety, and adverse reactions in patients. Therefore, this combination therapy is recommended for the clinical treatment of adolescent depression.

Efficacy of Cognitive Behavioral Therapy and Physical Exercise in Alleviating Treatment-Induced Menopausal Symptoms in Patients With Breast Cancer: Results of a Randomized, Controlled, Multicenter Trial

2012 ◽  
Vol 30 (33) ◽  
pp. 4124-4133 ◽  
Author(s):  
Saskia F.A. Duijts ◽  
Marc van Beurden ◽  
Hester S.A. Oldenburg ◽  
Myra S. Hunter ◽  
Jacobien M. Kieffer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Exercise ◽  
Cognitive Behavioral Therapy ◽  
Physical Functioning ◽  
Effect Size ◽  
Rating Scale ◽  
Behavioral Therapy ◽  
Menopausal Symptoms ◽  
Control Group ◽  
Endocrine Symptoms

Purpose The purpose of our study was to evaluate the effect of cognitive behavioral therapy (CBT), physical exercise (PE), and of these two interventions combined (CBT/PE) on menopausal symptoms (primary outcome), body image, sexual functioning, psychological well-being, and health-related quality of life (secondary outcomes) in patients with breast cancer experiencing treatment-induced menopause. Patients and Methods Patients with breast cancer reporting treatment-induced menopausal symptoms (N = 422) were randomly assigned to CBT (n = 109), PE (n = 104), CBT/PE (n = 106), or to a waiting list control group (n = 103). Self-report questionnaires were completed at baseline, 12 weeks, and 6 months. Multilevel procedures were used to compare the intervention groups with the control group over time. Results Compared with the control group, the intervention groups had a significant decrease in levels of endocrine symptoms (Functional Assessment of Cancer Therapy–Endocrine Symptoms; P < .001; effect size, 0.31-0.52) and urinary symptoms (Bristol Female Lower Urinary Tract Symptoms Questionnaire; P = .002; effect size, 0.29-0.33), and they showed an improvement in physical functioning (36-Item Short Form Health Survey physical functioning subscale; P = .002; effect size, 0.37-0.46). The groups that included CBT also showed a significant decrease in the perceived burden of hot flashes and night sweats (problem rating scale of the Hot Flush Rating Scale; P < .001; effect size, 0.39-0.56) and an increase in sexual activity (Sexual Activity Questionnaire habit subscale; P = .027; effect size, 0.65). Most of these effects were observed at both the 12-week and 6-month follow-ups. Conclusion CBT and PE can have salutary effects on endocrine symptoms and, to a lesser degree, on sexuality and physical functioning of patients with breast cancer experiencing treatment-induced menopause. Future work is needed to improve the design and the planning of these interventions to improve program adherence.

Internet‐based cognitive-behavioral therapy (I-CBT) for problem drinkers: systematic review and meta-analysis (Preprint)

2020 ◽  
Author(s):  
Seung-Hun Cho ◽  
Yu Kyung Lee
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Cognitive Behavioral Therapy ◽  
Randomized Controlled Trials ◽  
Behavioral Therapy ◽  
Meta Analysis ◽  
Control Group ◽  
Controlled Trials ◽  
Problem Drinkers ◽  
Randomized Controlled

BACKGROUND The use of cognitive‐behavioral therapy (CBT) for the efficient treatment of alcohol use has been validated by long‐standing evidence. However, there have been some reviews indicating the efficacy of internet‐based CBT (I-CBT) for various psychiatric conditions. OBJECTIVE To quantify the overall effectiveness of internet‐delivered CBT for problem drinkers and estimate the effect of this approach compared with control group. METHODS We conducted systematic searches in EMBASE, PubMed, PsycINFO and CINAHL up to October 2019. Descriptive data were used to characterize the nature of the literature on I-CBT for alcohol use. Meta‐analysis was performed of effect sizes from randomized controlled trials. RESULTS Fourteen randomized controlled trials for alcohol use with 11827 participants were identified and included in this study. Our results showed a significant overall effect in favor of I-CBT. I-CBT showed significant effect size (-0.23 :95% confidence interval, from -0.41 to -0.06; P = 0.008) on alcohol consumption as compared to the control group. The quality of studies varied. CONCLUSIONS This review shows that I-CBT for problem drinkers is more effective as compared to no treatment, minimal treatment, or usual care in reducing alcohol consumption. Findings of this review suggest that accessible internet‐delivered CBT may represent a cost‐effective means of treating alcohol abuse.

Effectiveness of group CBT in treating adolescents with depression symptoms: a critical review

2016 ◽  
Vol 29 (3) ◽  
Author(s):  
Bernardo Nardi ◽  
Micaela Massei ◽  
Emidio Arimatea ◽  
Andrés Moltedo-Perfetti
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Behavioral Therapy ◽  
Adolescent Depression ◽  
Behavioral Therapy ◽  
Therapy Group ◽  
Cognitive Behavioral ◽  
Control Group ◽  
Depression Symptoms ◽  
Self Awareness ◽  
Pubmed Search

Abstract Depression is among the most common psychological disorders of adolescents. Its management is based on pharmacological treatment, psychological therapy, or a combination thereof. Cognitive behavioral therapy (CBT) is the most extensively tested intervention for adolescent depression. A PubMed search was conducted for randomized controlled trials (RCT) of the efficacy of CBT in treating adolescents with depressive symptoms published in 2005–2015. Keywords were “cognitive behavioral therapy”, “group therapy”, “depression” and “adolescent”. Of the 23 papers that were retrieved, only six met all inclusion criteria. Three of them reported a significant reduction in depressive symptom severity after either individual or group (G)-CBT compared with the control group, even with a small number of CBT sessions (six rather than 10–12), with a medium or medium-to-large effect size. One study reported improved self-awareness and a significantly greater increase in perceived friend social support compared with bibliotherapy and check with brochure. Two studies reported clinical symptom reduction without significant differences compared with the control group (activity contrast). This review highlighted primarily that very few RCT have applied CBT in adolescents; moreover, it confirmed the effectiveness of G-CBT, especially as psychotherapy, although it was not always superior to other interventions (e.g. other activities in prevention programs). Comparison showed that G-CBT and group interpersonal psychotherapy were both effective in reducing depressive symptoms. Successful G-CBT outcomes were related to the presence of peers, who were an important source of feedback and support to observe, learn, and practice new skills to manage depressive symptoms and improve social-relational skills.

RELATED FACTORS TO RELAPSE IN DEPRESSED PATIENTS AFTER COGNITIVE BEHAVIOURAL THERAPY DURING ONE YEAR PROSPECTIVE FOLLOW-UP

2011 ◽  
pp. 13-19
Author(s):  
Nhu Minh Hang Tran ◽  
Huu Cat Nguyen ◽  
Dang Doanh Nguyen ◽  
Van Luong Ngo ◽  
Vu Hoang Nguyen ◽  
...  
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Relapse Rate ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Related Factors ◽  
Depressed Patients ◽  
One Year

Objectives: To determine factors impact on the relapse in depressed patients treated with Cognitive Behavioral Therapy (CBT) during one year follow-up. Materials and Methods: 80 depressed patients divided into two groups, group 1: included 40 patients treated with CBT; group 2: 40 patients on amitriptyline. Non-randomized controlled clinical trial, opened, longiditual and prospective research. Results and Conclusions: relapse rate after CBT during 1 year follow-up is 10% (compared to 25% in control group), related factors to relapse rate in depression after CBT are age and education. Shared predictors between 2 groups are severity and recurrence of depression. Key words: Depression, relapse, Cognitive Behavioral Therapy (CBT)

349 Cognitive Behavioral Therapy for Insomnia in Patients with Chronic Pain - A Systematic Review and Meta-Analysis

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A139-A140
Author(s):  
Janannii Selvanathan ◽  
Chi Pham ◽  
Mahesh Nagappa ◽  
Philip Peng ◽  
Marina Englesakis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Behavioral Therapy ◽  
Cancer Pain ◽  
Behavioral Therapy ◽  
Meta Analysis ◽  
Post Treatment ◽  
Cognitive Behavioral ◽  
Comorbid Insomnia ◽  
Patient Reported

Abstract Introduction Patients with chronic non-cancer pain often report insomnia as a significant comorbidity. Cognitive behavioral therapy for insomnia (CBT-I) is recommended as the first line of treatment for insomnia, and several randomized controlled trials (RCTs) have examined the efficacy of CBT-I on various health outcomes in patients with comorbid insomnia and chronic non-cancer pain. We conducted a systematic review and meta-analysis on the effectiveness of CBT-I on sleep, pain, depression, anxiety and fatigue in adults with comorbid insomnia and chronic non-cancer pain. Methods A systematic search was conducted using ten electronic databases. The duration of the search was set between database inception to April 2020. Included studies must be RCTs assessing the effects of CBT-I on at least patient-reported sleep outcomes in adults with chronic non-cancer pain. Quality of the studies was assessed using the Cochrane risk of bias assessment and Yates quality rating scale. Continuous data were extracted and summarized using standard mean difference (SMD) with 95% confidence intervals (CIs). Results The literature search resulted in 7,772 articles, of which 14 RCTs met the inclusion criteria. Twelve of these articles were included in the meta-analysis. The meta-analysis comprised 762 participants. CBT-I demonstrated a large significant effect on patient-reported sleep (SMD = 0.87, 95% CI [0.55–1.20], p &lt; 0.00001) at post-treatment and final follow-up (up to 9 months) (0.59 [0.31–0.86], p &lt; 0.0001); and moderate effects on pain (SMD = 0.20 [0.06, 0.34], p = 0.006) and depression (0.44 [0.09–0.79], p= 0.01) at post-treatment. The probability of improving sleep and pain following CBT-I at post-treatment was 81% and 58%, respectively. The probability of improving sleep and pain at final follow-up was 73% and 57%, respectively. There were no statistically significant effects on anxiety and fatigue. Conclusion This systematic review and meta-analysis showed that CBT-I is effective for improving sleep in adults with comorbid insomnia and chronic non-cancer pain. Further, CBT-I may lead to short-term moderate improvements in pain and depression. However, there is a need for further RCTs with adequate power, longer follow-up periods, CBT for both insomnia and pain, and consistent scoring systems for assessing patient outcomes. Support (if any):

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