scholarly journals SAPHO Syndrome Mimicking Infectious Spondylodiscitis and Bone Metastasis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
S. Biuden ◽  
K. Maatallah ◽  
H. Riahi ◽  
H. Ferjani ◽  
M. D. Kaffel ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Blood Analysis ◽  
Sapho Syndrome ◽  
Lumbar Pain ◽  
Sacroiliac Joints ◽  
Typical Pattern ◽  
X Ray ◽  
Soft Tissue Involvement ◽  
Infectious Spondylodiscitis ◽  
Skin Conditions

The acronym SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) includes diseases with similar osteoarticular manifestations and skin conditions. Making this diagnosis is not always obvious, especially when the clinical presentation does not fit the typical pattern of the disease or it occurs in a particular field. We described three cases where the diagnosis was difficult. A 46 year-old woman presented with cervical pain. The cervical X-ray showed the aspect of an ivory C5 vertebra. The patient had, however, preserved general condition, no signs of underlying neoplasia, nor other joint complaints. Blood analysis was normal. Tomography did not find any suspect lesion but showed sclerosis and hyperostosis of the manubrium. Scintigraphy showed the characteristic “bullhead” appearance. A 61-year-old woman had thoracic and lumbar pain. MRI showed spondylodiscitis in D3-D4, D4-D5, D5-D6, D6-D7, and L1-L2 with paraspinal soft tissue involvement, simulating infectious spondylodiscitis. Infectious investigations and discovertebral biopsy performed twice were negative. SAPHO syndrome was then suspected. Bone scintigraphy showed uptake in the chondrosternal articulations and D4 to D7 vertebrae. The diagnosis of SAPHO was established. The third case was a 46-year-old man with a lung adenocarcinoma. Staging for metastatic disease, a TAP tomography was performed and showed osteosclerosis of D8 to D12 and intra-articular bridges in the sacroiliac joints. MRI and scintigraphy eliminated malignancy and confirmed the diagnosis of SAPHO. In our cases, imaging findings could facilitate differentiating SAPHO syndrome from other diseases.

scholarly journals Giant Calculus in the Ureteropelvic Junction: A Case Report

2014 ◽  
Vol 15 (1) ◽  
pp. 91-93
Author(s):  
Luis Domingos R. Costa ◽  
Raffael M. Alvarenga ◽  
Yvis E. De Jesus De Oliveira ◽  
Fernanda T. Soares ◽  
Geraldo B Silva Junior ◽  
...  
Keyword(s):  
Social Impact ◽  
Recurrent Urinary Tract Infection ◽  
Left Kidney ◽  
Ureteropelvic Junction ◽  
Lumbar Pain ◽  
Ureteral Calculus ◽  
Left Ureter ◽  
X Ray ◽  
Urinary Lithiasis ◽  
Grade Iii

Urinary lithiasis is an affection of high social impact associated with high costs. Its incidence varies from 1 to 15% in the general population and has a recurrence chance of 26-50%. We report one rare case of giant ureteral calculus in the ureteropelvic junction in a patient with complaints of left lumbar pain and recurrent urinary tract infection diagnosed in the outpatients‘ Urology clinics. Antibioticotherapy was instituted and complementary tests were done. The abdomen x-ray showed a large opacity in the left kidney topography, and the computed tomography evidenced a giant left ureteral calculus associated with a large ureteropelvic junction dilation and grade III hydronephrosis. An ureterolitothomy was performed and evidenced a calculus of 9.5x6.5cm and weighting 347g. The patient became well after the surgery, and a pyelogram evidenced dilation of both caliceal groups and left ureter, without any calculus. Urinary lithiasis should be early diagnosed and treated in order to avoid severe complications as the presented here.DOI: http://dx.doi.org/10.3329/jom.v15i1.19884 J Medicine 2014; 15: 91-93

scholarly journals Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1148 ◽  
Author(s):  
Chun-Chen Yang ◽  
Wei-Yun Wang ◽  
Feng-Huei Lin ◽  
Chun-Han Hou
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Light Source ◽  
Reactive Oxygen ◽  
Blood Analysis ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

scholarly journals Laparoscopic approach for diaphragmatic hernia repair in adult: our experience of four cases

2020 ◽  
Vol 2020 (6) ◽  
Author(s):  
Abhijeet Kumar ◽  
Ratish Karn ◽  
Bhawani Khanal ◽  
Suresh Prasad Sah ◽  
Rakesh Gupta
Keyword(s):  
Diaphragmatic Hernia ◽  
Clinical Presentation ◽  
Clinical Investigation ◽  
Gastrointestinal Symptoms ◽  
Laparoscopic Approach ◽  
X Ray ◽  
Patch Closure ◽  
Thoracic Approach ◽  
Diaphragmatic Hernias ◽  
Tomography Scan

Abstract Diaphragmatic hernia can be congenital or acquired. Usual clinical presentation may range from asymptomatic cases to serious respiratory/gastrointestinal symptoms and occasionally atypical presentation as lumbar hernia also. The diagnosis of diaphragmatic hernia is based on clinical investigation and is confirmed by plain X-ray film and computed tomography scan. Various treatment approaches, open, laparoscopic and combination, are available for this condition. However, laparoscopic approach has recently gained in popularity. Surgical repair typically involves primary or patch closure of the diaphragm through an open or endoscopic abdominal or thoracic approach. This paper reflects our experience of repair of diaphragmatic hernias to evaluate its safety, efficacy and outcomes.

Otosclerotic Stapes: Morphological and Microchemical Correlates

1977 ◽  
Vol 86 (4) ◽  
pp. 525-540 ◽  
Author(s):  
David J. Lim ◽  
William H. Saunders
Keyword(s):  
Calcium Salt ◽  
Mineral Deposit ◽  
Ground Substance ◽  
X Ray Diffraction ◽  
Typical Pattern ◽  
X Ray ◽  
Initial Stage ◽  
Electron Microscopes ◽  
Sclerotic Lesions ◽  
Scanning Electron Microscopes

A total of 32 otosclerotic stapes is thin-sectioned without decalcification and examined using transmission and scanning electron microscopes, with a nondispersive x-ray analyzer attached to the latter. These otosclerotic stapes are classified as spongiotic, sclerotic, or preotosclerotic, according to their pathologic characteristics and state of mineralization. Either diffuse or patchy demineralization in the ground substance appears to be the initial stage of otosclerosis, and this area coincides with preotosclerotic lesions (also known as blue mantle) in light microscopy. Therefore, it is interpreted that demineralization precedes the destruction of ground substance in the preotosclerotic lesion. Bone mineral deposits in new otosclerotic bone appear to be related to the collagen fibrils that are embedded in the ground substance. No mineral deposit could be seen without the ground substance deposition; therefore, it is suggested that this ground substance is the single most important factor in the poor mineralization of the otosclerosis. The sclerotic lesions are well mineralized and show a typical pattern of hydroxyapatite by x-ray diffraction study. We could not confirm the notion that the sclerotic lesion is hypermineralized as compared to the normal stapes. The spongiotic lesions are poorly mineralized, with low calcium salt. Using the Ca/P ratio and x-ray diffraction pattern as criteria, it was determined that spongiotic lesions belong to unstable, immature bone.

Demonstration of whole blood analysis using proton-induced x-ray emission

1976 ◽  
Vol 3 (2) ◽  
pp. 91-94 ◽  
Author(s):  
J. J. Malanify ◽  
C. E. Burns ◽  
D. A. Close ◽  
R. C. Bearse
Keyword(s):  
Whole Blood ◽  
Blood Analysis ◽  
X Ray ◽  
Whole Blood Analysis

scholarly journals The Pattern of Presentation and Prevalence of Tuberculosis in HIV-Seropositive Patients Seen at Benin City, Nigeria

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Christopher C. Affusim ◽  
Emeka Kesieme ◽  
Vivien O. Abah
Keyword(s):  
Clinical Presentation ◽  
Signs And Symptoms ◽  
Hiv Positive ◽  
X Ray ◽  
Benin City ◽  
Immunodeficiency Virus ◽  
High Incidence ◽  
Chest X Ray ◽  
Negative Sputum ◽  
Hiv Seropositive

Background. The emergence of Human immunodeficiency virus (HIV), led to the rise in the incidence and prevalence of tuberculosis (TB) worldwide. However, the trend is being reversed recently due to the widespread use of effective Anti-Retrovirals. Immunosuppression induced by HIV infection modified the clinical presentation of TB, resulting in atypical signs and symptoms, and a more frequent extrapulmonary presentation. This study was undertaken to determine the pattern of presentation and prevalence of TB in HIV seropositive patients seen in Benin City, Nigeria, from January to April, 2007. Method. The study was done using 330 HIV positive patients (123 males and 207 females). A designed questionnaire was used as a diagnostic instrument. Results. The prevalence of TB HIV was found to be 33.9%. It was found to be commoner in females, commonest in the age group 30–39 years. Pulmonary TB was the commonest type of TB found (78.6%). This was followed by TB adenitis (12.5%). The incidence of extrapulmonary TB was 21.4%. There was a high incidence of atypical chest X-ray features and high frequency of negative sputum smears. Conclusions. The overall prevalence rate of TB in HIV (33.9%), and the extrapulmonary presentation of TB are high. Some investigation results were found to be atypical in those with both infections. Physicians should be aware of this pattern of presentation and the atypical findings on investigation for early diagnosis and treatment.

scholarly journals A Painful Shoulder Revealing Langerhans Cell Histiocytosis

2020 ◽  
pp. 24-27
Author(s):  
N. A. R. Ranaivo ◽  
M. L. Rakotomahefa Narison ◽  
M. Bemena ◽  
S. H. Raobijaona
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Clinical Presentation ◽  
Bone Lesion ◽  
Langerhans Cell ◽  
Irregular Boundary ◽  
X Ray ◽  
Multidisciplinary Consultation ◽  
Life Threatening ◽  
Spontaneous Improvement ◽  
The Right

Introduction: Langerhans cell histiocytosis is a systemic proliferative disease. It is a rare disease that can affects all tissues. Evolution can be spontaneously favorable. Multi-organ involvement may be life-threatening. We report the case of an toddler with bone lesion and issues. Case Report: It was a 33-month-old infant with right shoulder pain. Clinically, she had a swelling in the front side of the right shoulder with a limited abduction. X-ray of the right shoulder showed osteolysis with an irregular boundary of the right humeral head. The blood work was normal. In view of the painful swelling of the right shoulder, a biopsy was performed. Histological examination confirmed the diagnosis of Langerhans histiocytosis. A conservative treatment was decided after a multidisciplinary consultation meeting. After six months, spontaneous improvement was noted. Conclusion: Langerhans cell histiocytosis is a proliferative pathology that can affect one or more organs. The clinical presentation is polymorphic according to the affected organ. An extension assessment is fundamental in the management in order to determine the treatment.

Sign in / Sign up

Export Citation Format

Share Document