scholarly journals Nicotine Ingestion Reduces Heart Rate Variability in Young Healthy Adults

2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Qian-nan Guo ◽  
Jing Wang ◽  
Hong-yan Liu ◽  
Dong Wu ◽  
Shi-xiu Liao
Keyword(s):  
Lung Cancer ◽  
Cardiovascular Disease ◽  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Rate Variability ◽  
Heart Disease ◽  
Healthy Male ◽  
Male And Female ◽  
Cardiac System ◽  
Main Component

Around the whole world, smoking is considered harmful to human health, such as increasing the risk of cardiovascular disease (CVD, such as coronary heart disease and stroke) and lung cancer. The purpose of this study was to explore whether nicotine, the main component of tobacco, has adverse effects on heart rate variability (HRV) in adolescents, so as to remind adolescents not to smoke and not to take pleasure in abusing nicotine. In this study, 40 male and 40 female young healthy nonsmoking subjects were selected to analyze the changes of HRV after taking 4 mg nicotine orally. We found that nicotine reduced HRV in young healthy male and female subjects, and there was no gender difference in this effect ( P > 0.05 ). In conclusion, smoking is harmful to the cardiac system of young people, especially when nicotine content ≥4 mg dosage.

Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the Heart and Soul Study

2014 ◽  
Vol 44 (14) ◽  
pp. 2975-2984 ◽  
Author(s):  
F. Zimmermann-Viehoff ◽  
L. K. Kuehl ◽  
H. Danker-Hopfe ◽  
M. A. Whooley ◽  
C. Otte
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Rate Variability ◽  
Heart Disease ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Tricyclic Antidepressants ◽  
Autonomic Function ◽  
Control Group ◽  
Observational Period ◽  
Lower Heart Rate

BackgroundAntidepressants reduce depressive symptoms in patients with coronary heart disease, but they may be associated with increased mortality. This study aimed to examine whether the use of tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRI) is associated with mortality in patients with coronary heart disease, and to determine whether this association is mediated by autonomic function.MethodA total of 956 patients with coronary heart disease were followed for a mean duration of 7.2 years. Autonomic function was assessed as heart rate variability, and plasma and 24-h urinary norepinephrine.ResultsOf 956 patients, 44 (4.6%) used TCA, 89 (9.3%) used SSRI, and 823 (86.1%) did not use antidepressants. At baseline, TCA users exhibited lower heart rate variability and higher norepinephrine levels compared with SSRI users and antidepressant non-users. At the end of the observational period, 52.3% of the TCA users had died compared with 38.2% in the SSRI group and 37.3% in the control group. The adjusted hazard ratio (HR) for TCA use compared with non-use was 1.74 [95% confidence interval (CI) 1.12–2.69, p = 0.01]. Further adjustment for measures of autonomic function reduced the association between TCA use and mortality (HR = 1.27, 95% CI 0.67–2.43, p = 0.47). SSRI use was not associated with mortality (HR = 1.15, 95% CI 0.81–1.64, p = 0.44).ConclusionsThe use of TCA was associated with increased mortality. This association was at least partially mediated by differences in autonomic function. Our findings suggest that TCA should be avoided in patients with coronary heart disease.

Non-linear analysis of heart rate variability in patients with coronary heart disease

2003 ◽  
Author(s):  
G. Krstacic ◽  
A. Krstacic ◽  
M. Martinis ◽  
E. Vargovic ◽  
A. Knezevic ◽  
...  
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Rate Variability ◽  
Heart Disease ◽  
Linear Analysis ◽  
Non Linear
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