scholarly journals Kinetic Study of DNA Modification by Phthalocyanine Derivative of the Oligonucleotide

2006 ◽  
Vol 2006 ◽  
pp. 1-10 ◽  
Author(s):  
Alexandra A. Kuznetsova ◽  
Alexander A. Chernonosov ◽  
Nikita A. Kuznetsov ◽  
Vladimir V. Koval ◽  
Dmitri G. Knorre ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hydrogen Peroxide ◽  
Transition Metal Complexes ◽  
Regulation Of Gene Expression ◽  
Dna Modification ◽  
Modified Oligonucleotides ◽  
Kinetics And Thermodynamics ◽  
Chemically Modified ◽  
Oxidation Of Organic Compounds ◽  
Reactive Groups

Design of chemically modified oligonucleotides for regulation of gene expression has attracted considerable attention over the last decades. One actively pursued approach involves antisense or antigene constructs carrying reactive groups, many of these based on transition metal complexes. The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide. In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence ofH2O2.

scholarly journals Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide

2011 ◽  
Vol 108 (7) ◽  
pp. 2729-2734 ◽  
Author(s):  
D. E. Fomenko ◽  
A. Koc ◽  
N. Agisheva ◽  
M. Jacobsen ◽  
A. Kaya ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hydrogen Peroxide ◽  
Regulation Of Gene Expression ◽  
Genome Wide

Transcriptional Regulation of Gene Expression Related to Hydrogen Peroxide (H2O2) and Nitric Oxide (NO)

2019 ◽  
pp. 69-90 ◽  
Author(s):  
Juan C. Begara-Morales ◽  
Mounira Chaki ◽  
Raquel Valderrama ◽  
Capilla Mata-Pérez ◽  
María Padilla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Hydrogen Peroxide ◽  
Transcriptional Regulation ◽  
Regulation Of Gene Expression

Linking transcription, RNA polymerase II elongation and alternative splicing

2020 ◽  
Vol 477 (16) ◽  
pp. 3091-3104 ◽  
Author(s):  
Luciana E. Giono ◽  
Alberto R. Kornblihtt
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Rna Polymerase Ii ◽  
Environmental Changes ◽  
Transcription Elongation ◽  
Single Gene ◽  
Regulation Of Gene Expression ◽  
Regulation Of Transcription ◽  
Stepping Stones ◽  
Eukaryotic Transcription

Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by which multiple functionally distinct transcripts are generated from a single gene, is one of the main mechanisms that contribute to expand the coding capacity of genomes and help explain the level of complexity achieved by higher organisms. Eukaryotic transcription is subject to multiple layers of regulation both intrinsic — such as promoter structure — and dynamic, allowing the cell to respond to internal and external signals. Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulate some of the history and stepping-stones that led to the paradigms held today about transcription and splicing regulation, with major focus on transcription elongation and its effect on alternative splicing.

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