Antimicrobial, Antifertility and Antiinflammatory Approach to
Tetradentate Macrocyclic Complexes of Iron(II) and Manganese(II)

Some antifertility inhibitors of 18 to 24-membered tetraazamacrocyclic complexes of iron(II) and manganese(II) have been synthesised by the template condensation using 1,3-phenylenediamine with malonic acid, succinic acid, glutaric acid and adipic acid. The reaction proceed smoothly to completion. The complexes were characterized by elemental analyses, molecular weight determinations, infrared, electronic, magnetic moment, mössbaur and mass spectral studies. The elemental analyses are consistent with the formation of the complexes [M(N4Ln)Cl2] (M = Fe(lI) or Mn(II)). All these complexes are stable and monomeric in nature as indicated by the molecular weight determinations. The spectral studies confirm the octahedral geometry around the central metal atom. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs have been examined and discussed.

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Diorganotin(IV) complexes of flexible N-protected amino acids and ketoximes: preparation and structure – antimicrobial activity relationship

Canadian Journal of Chemistry ◽

10.1139/cjc-2015-0126 ◽

2016 ◽

Vol 94 (2) ◽

pp. 155-162 ◽

Cited By ~ 1

Author(s):

Arti Sharma ◽

Asha Jain ◽

Sanjiv Saxena

Keyword(s):

Amino Acids ◽

Molecular Weight ◽

Antimicrobial Activity ◽

Spectral Data ◽

Molar Ratio ◽

Spectral Studies ◽

Sodium Salts ◽

Mass Spectral ◽

Elemental Analyses

Diorganotin(IV) complexes of flexible N-protected amino acids and ketoximes having the compositions Me2Sn [[Formula: see text]CHRCOO][ON = C6H10] (where R = –CH2CH(CH3)2, –CH(CH3)C2H5,–CH2C6H5, –CH(CH3)2) and Me2Sn[[Formula: see text]CHRCOO][ON=CR′R″] (where R = –CH2CH(CH3)2, –CH(CH3)C2H5, –CH2C6H5, R′ = R″ = CH3; R = –CH(CH3)C2H5, –CH2C6H5, –CH(CH3)2, R′ = CH3, R″ = C6H5) were prepared by the reaction of dimethyltin(IV) dichloride with sodium salts of flexible N-protected amino acids and ketoximes in 1:1:1 molar ratio in refluxing dry benzene. The synthesized complexes were characterized by elemental analyses and IR, multinuclear NMR (1H, 13C, and 119Sn), and mass spectral studies. Plausible structures of these complexes have been suggested on the basis of molecular weight measurements and spectral data. 119Sn NMR spectral data indicate the presence of pentacoordinated tin centres in these complexes. Some of the synthesized complexes and their ligands were also screened for their in vitro antimicrobial activity.

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Fertility Inhibitor Heterobimetallic Complexes of Platinum(II) and Palladium(II): Synthetic, Spectroscopic and Antimicrobial Aspects

Metal-Based Drugs ◽

10.1155/mbd.2000.105 ◽

2000 ◽

Vol 7 (2) ◽

pp. 105-113 ◽

Cited By ~ 15

Author(s):

Kripa Sharma ◽

S. C. Joshi ◽

R. V. Singh

Keyword(s):

Sperm Morphology ◽

Pathogenic Fungi ◽

Reproductive Organs ◽

Spectral Studies ◽

Planar Geometry ◽

Testicular Sperm ◽

Heterobimetallic Complexes ◽

Sperm Density ◽

Square Planar ◽

Elemental Analyses

Synthetic, spectroscopic and antimicrobial aspects of some fertility inhibitor heterobimetallic complexes have been carried out. These heterobimetallic chelates [M(C5H5N3)2M2'(R)4]Cl2 (M = Pd or Pt and M' = Si, Sn, Ti and Zr) have been successfully synthesinzed via the reaction of M(C5H7N3)2Cl2 with group four or fourteen dichlorides in 1:2 stoichiometric proportions. The products were characterized by elemental analyses, molecular weight determinations, magnetic susceptibility measurements, conductance, and IR multinuclear NMR and electronic spectral studies. A square planar geometry has been suggested for all the complexes with the help of spectral data. Conductivity data strongly suggest that chlorine atoms are ionic in nature due to which complexes behave as electrolytes. All the complexes have been evaluated for their antmicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.

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Synthesis, Characterization and Antifertility Activity of New Unsymmetrical Macrocyclic Complexes of Tin(II)

Metal-Based Drugs ◽

10.1155/mbd.2000.237 ◽

2000 ◽

Vol 7 (5) ◽

pp. 237-243 ◽

Cited By ~ 5

Author(s):

Kripa Sharma ◽

S. C. Joshi ◽

R. V. Singh

Keyword(s):

Metal Ion ◽

Amino Nitrogen ◽

Pathogenic Fungi ◽

Ring Expansion ◽

Macrocyclic Complexes ◽

Molar Ratio ◽

Spectral Studies ◽

Testicular Sperm ◽

Sperm Density

A new series of unsymmetrical macrocyclic complexes of tin(ll) has been prepared by the template process using bis(3-oxo-2-butylidene)propane-1,3-diamine as precursor. This affords a method to synthesize these complexes with various ring sizes. The tetradentate macrocyclic precursor [N4mL] reacts with SnCl2 and different diamines in a 1:1:1 molar ratio in refluxing methanol to give complexes of the type [Sn(N4mL)Cl2]. The ring expansion has been achieved by varying the diamine between the two diacetyl amino nitrogen atoms. The macrocyclic precursor and its metal complexes have been characterized on the basis of elemental analysis, molar conductance, molecular weight determinations, IR, H1 NMR,C13 NMR, Sn119 NMR and electronic spectral studies. An octahedral geometry around the metal ion is suggested for these complexes. On the basis of molecular weights and conductivity measurements, their monomeric and non-electrolytic nature has been confirmed. The precursor and complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemicals parameters of reproductive organs have been examined and discussed.

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Preparation and Spectroscopic Characterisation of a Series of Heterobimetallic N-phenyldiethanolaminate-alkoxide Derivatives of Oxovanadium(V)

Journal of Chemical Research ◽

10.3184/0308234054506857 ◽

2005 ◽

Vol 2005 (6) ◽

pp. 352-355 ◽

Cited By ~ 3

Author(s):

Rajendra Singh Ghadwal ◽

Ram C. Mehrotra ◽

Anirudh Singh

Keyword(s):

Molecular Weight ◽

Spectral Studies ◽

Metal Alkoxides ◽

Nmr Studies ◽

Mass Spectral ◽

Elemental Analyses ◽

Derivatives Of ◽

Spectroscopic Characterisation

Reaction of VO(OPri)3 with two equivalents of N-phenyldiethanolamine (PhDEAH2) yields a homometallic complex [VO(PhDEA)(PhDEAH)] 1, which reacts with a number of metal alkoxides to afford heterobimetallic oxovanadium(V) complexes of the types [VO(PhDEA)2{M(OR)n-1}] [where PhDEA = C6H5N(CH2CH2O–)2], [M =: Al (n = 3, R = Pri) 2; Al (n = 3, R = But) 3; Ti (n = 4, R = Pri) 4; Zr (n = 4, R = Pri) 5; Nb (n = 5, R = Pri) 6; Ta (n = 5, R = Pri) 7. The derivative [VO(PhDEA)(OSiPh3)] 8 has been prepared by the equimolar interaction of [VO(PhDEA)(OPri)] with Ph3SiOH. All of these complexes have been characterised by spectroscopic (IR; 1H, 13C, 27Al and 51V NMR) studies, elemental analyses, and molecular weight measurements. The derivative 2 has also been characterised by FAB mass spectral studies, which supports for its monomeric nature.

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Synthesis, Characterization, and Evaluation of Antimicrobial and Antifertility Efficacy of Heterobimetallic Complexes of Copper (II)

Journal of Chemistry ◽

10.1155/2017/5936465 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Ashu Chaudhary ◽

Anshul Singh

Keyword(s):

Reproductive Organs ◽

Male Rats ◽

Spectral Studies ◽

Molecular Weight Determination ◽

Mass Spectral ◽

Heterobimetallic Complexes ◽

Group 4 ◽

Electronic Spin ◽

Substantial Decline

Heterobimetallic complexes of the copper with remarkable antimicrobial and antifertility action have been synthesized by the conventional method by reacting CuCl2 and o-phenylenediamine in the methanolic medium forming the mononuclear complex of the type CuC6H8N22Cl2 which was further treated with group 4 or 14 organometallic dichlorides (Ph2M′Cl2, Me2M′Cl2, and Cp2M′′Cl2) [M′ = Sn, Si, and M′′ = Ti, Zr] leading to formation of heterobimetallic complexes. All the synthesized complexes were characterized in the light of various physicochemical techniques like elemental analyses, conductivity measurements, molecular weight determination, electronic and infrared spectra, electronic spin resonance, X-ray, and mass spectral studies. The in vitro antibacterial activity of synthesized complexes against Escherichia coli and Staphylococcus aureus was tested to evaluate their inhibiting activities. The antifungal activities of mono- and heterobimetallic complexes were studied by screening the compounds against Fusarium oxysporum and Alternaria alternata. These complexes were then investigated to reveal their effect on the reproductive organs of male rats. The treatment has shown substantial decline in the sperm motility and density signifying the imperious antifertility activity.

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Synthesis, Characterization, In Vitro and In Vivo Screening of Unsymmetrical Borole Complexes of 2-Hydroxy-N-Phenylbenzamide and its Derivatives

Metal-Based Drugs ◽

10.1155/mbd.2000.7 ◽

2000 ◽

Vol 7 (1) ◽

pp. 7-16 ◽

Cited By ~ 8

Author(s):

Taruna Pandey ◽

R. V. Singh

Keyword(s):

Pathogenic Fungi ◽

Reproductive Organs ◽

Molar Ratio ◽

Testicular Sperm ◽

Sperm Density ◽

Bactericidal Properties ◽

Boron Complexes

Biochemical aspects, synthesis and characterization of some boron complexes of 2-hydroxy-N-phenylbenzamide (HOPhBenz) and its semicarbazone (HOPhBenz.SCZH) and thiosemicarbazone (HOPhBenz.TSCZH) are described. These derivatives were prepared by the reactions of 2-isopropoxy-4-methyl-1,3,2-dioxaborolane, and 2-isopropoxy-4-methyl-1,3,2-dioxaborinane with 2-hydroxy-N-phenylbenzamide, 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarboxamide (HOPhBenz.SCZH), and 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarbothioamide(HOPhBenz.TSCZH) in a 1:1 molar ratio. In order to assess the increase of the inhibitor potency, (HOPhBenz), (HOPhBenz.SCZH), (HOPhBenz.TSCZH) and their boron complexes have been tested in vitro against a number of pathogenic fungi and bacteria at different concentrations and were found to possess remarkable fungicidal and bactericidal properties. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs are discussed.

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Synthesis and characterization of barbitones as antimicrobial agents

Journal of the Serbian Chemical Society ◽

10.2298/jsc0606587s ◽

2006 ◽

Vol 71 (6) ◽

pp. 587-591 ◽

Cited By ~ 6

Author(s):

H.G. Sangani ◽

K.B. Bhimani ◽

R.C. Khunt ◽

A.R. Parikh

Keyword(s):

Antimicrobial Activity ◽

Barbituric Acid ◽

Antimicrobial Agents ◽

Spectral Studies ◽

Synthesis And Characterization ◽

Mass Spectral ◽

Elemental Analyses ◽

Bacteria And Fungi

Barbitones (3) were synthesised by the condensation of chalcones (2) with barbituric acid. The structure of the synthesized compounds were assigned on the basis of elemental analyses, IR, NMR and mass spectral studies. All the products were evaluated for their in vitro antimicrobial activity against various strains of bacteria and fungi.

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Synthesis, Spectral Characterization and Biological Evaluation of Metal Complexes of 2-Thioxoquinoline Aminophenol

Asian Journal of Chemistry ◽

10.14233/ajchem.2021.23233 ◽

2021 ◽

Vol 33 (6) ◽

pp. 1439-1446

Author(s):

G. Gokulnath ◽

P. Anitha ◽

R. Manikandan ◽

C. Umarani

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Biological Evaluation ◽

Spectral Studies ◽

Central Metal Atom ◽

Central Metal ◽

Cervical Cancer Cells ◽

Ft Ir ◽

Escherichia Coli Bacteria

A series of novel 2-thioxoquinoline aminophenol Schiff base based Co(II), Ni(II), Cu(II) and Zn(II) metal complexes [M(L)2], (M = Co2+, Ni2+, Cu2+ & Zn2+; L = 2-thioxoquinoline aminophenol) were synthesized and characterized by elemental analysis and spectral studies (FT-IR, UV-Vis, 1H NMR, ESR and ESI-Mass). All experimental results showed that in these metal complexes, the central metal atom was coordinated by oxygen, nitrogen and sulfur donor atoms of deprotonated Schiff base. Further, the ligand and its metal(II) complexes were screened against Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli) bacteria and fungus (Candida albicans) strains. in vitro Anticancer activity of ligand and its metal(II) complexes were also screened against HeLa cells (Human cervical cancer cells).

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Synthetic, structural and biological studies of organosilicon(IV) complexes of Schiff bases derived from pyrrole-2-carboxaldehyde

Journal of the Serbian Chemical Society ◽

10.2298/jsc081216063s ◽

2010 ◽

Vol 75 (7) ◽

pp. 917-927 ◽

Cited By ~ 9

Author(s):

Kiran Singh ◽

Dharam Pal

Keyword(s):

Schiff Bases ◽

Pathogenic Bacteria ◽

Antimicrobial Properties ◽

Molar Conductance ◽

Azomethine Nitrogen ◽

Spectral Studies ◽

Central Metal Atom ◽

Central Metal ◽

Biological Studies

Selected new organosilicon(IV) complexes having the general formula R2SiCl[L] and R2Si[L]2 were synthesized by the reactions of Me2SiCl2 with Schiff bases [5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole, 5-mercapto-3-methyl-4-(2-pyrrolecarboxalidene amino)-s-triazole and 3-ethyl-5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole] in 1:1 and 1:2 molar ratios. All of the compounds were characterized by elemental analysis, molar conductance, and IR, UV, 1H-, 13C- and metal-NMR spectral studies. All the spectral data suggest an involvement with an azomethine nitrogen in coordination to the central metal atom. With the help of above-mentioned spectral studies, penta and hexacoordinated environments around the central metal atoms in the 1:1 and 1:2 complexes, respectively, are proposed. Finally, the free ligands and their metal complexes were tested in vitro against some pathogenic bacteria and fungi to assess their antimicrobial properties.

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Potentially Biodynamic Tetraaza Macrocycles and their Manganese Complexes: Antiandrogen, Antimicrobial and PDI Studies

Bioinorganic Chemistry and Applications ◽

10.1155/bca.2005.161 ◽

2005 ◽

Vol 3 (3-4) ◽

pp. 161-177 ◽

Cited By ~ 5

Author(s):

Ashu Chaudhary ◽

Anita Phor ◽

R. V. Singh

Keyword(s):

Dicarboxylic Acids ◽

Reproductive Organs ◽

Spectral Studies ◽

X Ray ◽

Sperm Density ◽

Elemental Analyses ◽

Testicular Morphology ◽

Tetraaza Macrocycles ◽

Tetraazamacrocyclic Ligands

Fourteen to eighteen membered tetraazamacrocyclic ligands N4TTD1–N4TTD4have been synthesized by the condensation of aliphatic diamines. H2N–(CH2)y–NH2(y = 2 or 3) and dicarboxylic acids, HOOC- (CH2)x–COOH (x = 1 or 2) in the presence of condensing reagents dicyclohexylcarbodiimide (DCHC) and 4- dimethylaminopyridine (DMAP). On reduction these macrocyclic ligands give N4TTD5-N4TTD8, which form complexes with manganese(II) acetate. The new products with octahedral geometry have been characterized by elemental analyses, molecular weight determinations, magnetic moment and spectral studiesviz., infrared, electronic, mass and X-ray. On the basis of the spectral studies the binding sites are proposed as the nitrogen atom of the macrocycles. The formulation of the complexes as [Mn(CH3COO)2(N4TTDn)] (where n = 1 - 8) has been established on the basis of chemical composition. To assess the growth inhibiting potential of the ligands and their manganese (II) complexes biological screening have been undertaken. The testicular morphology, testicular sperm density, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs with ligands and their corresponding complexes, in vivo have also been described in the this communication.

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