scholarly journals Synthesis, Characterization and Antifertility Activity of New Unsymmetrical Macrocyclic Complexes of Tin(II)

2000 ◽  
Vol 7 (5) ◽  
pp. 237-243 ◽  
Author(s):  
Kripa Sharma ◽  
S. C. Joshi ◽  
R. V. Singh
Keyword(s):  
Metal Ion ◽  
Amino Nitrogen ◽  
Pathogenic Fungi ◽  
Ring Expansion ◽  
Macrocyclic Complexes ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Testicular Sperm ◽  
Sperm Density

A new series of unsymmetrical macrocyclic complexes of tin(ll) has been prepared by the template process using bis(3-oxo-2-butylidene)propane-1,3-diamine as precursor. This affords a method to synthesize these complexes with various ring sizes. The tetradentate macrocyclic precursor [N4mL] reacts with SnCl2 and different diamines in a 1:1:1 molar ratio in refluxing methanol to give complexes of the type [Sn(N4mL)Cl2]. The ring expansion has been achieved by varying the diamine between the two diacetyl amino nitrogen atoms. The macrocyclic precursor and its metal complexes have been characterized on the basis of elemental analysis, molar conductance, molecular weight determinations, IR, H1 NMR,C13 NMR, Sn119 NMR and electronic spectral studies. An octahedral geometry around the metal ion is suggested for these complexes. On the basis of molecular weights and conductivity measurements, their monomeric and non-electrolytic nature has been confirmed. The precursor and complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemicals parameters of reproductive organs have been examined and discussed.

scholarly journals Antiandrogen and Antimicrobial Aspects of Coordination Compounds of Palladium(II), Platinum(II) and Lead(II)

2001 ◽  
Vol 8 (3) ◽  
pp. 149-158 ◽  
Author(s):  
R. V. Singh ◽  
S. C. Joshi ◽  
Shalini Kulshrestha ◽  
Pooja Nagpal ◽  
Anil Bansal
Keyword(s):  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Testicular Sperm ◽  
Sperm Density

Synthesis, characterization and antimicrobial activities of an interesting class of biologically potent macrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed. The resulting biologically active [M(MaLn)(R2)]Cl2 and [Pb(MaLn)(R2)X2] (where, M = PdII or PtII and X = Cl or NO3) type of complexes have been synthesized by the reactions of macrocyclic ligands (MaLn) with metal salts and different diamines in 1:1:1 molar ratio in methanol. Initially the complexes were characterized by elemental analyses, molecular weight determinations and conductivity measurements. The mode of bonding was established on the basis of IR, H1 NMR, C13 NMR, Pt195 NMR, Pb207 NMR, XRD and electronic spectral studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged by benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium and platinum complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedral geometry is suggested for lead complexes.

scholarly journals Synthesis, Characterization, In Vitro and In Vivo Screening of Unsymmetrical Borole Complexes of 2-Hydroxy-N-Phenylbenzamide and its Derivatives

2000 ◽  
Vol 7 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Taruna Pandey ◽  
R. V. Singh
Keyword(s):  
Pathogenic Fungi ◽  
Reproductive Organs ◽  
Molar Ratio ◽  
Testicular Sperm ◽  
Sperm Density ◽  
Bactericidal Properties ◽  
Boron Complexes

Biochemical aspects, synthesis and characterization of some boron complexes of 2-hydroxy-N-phenylbenzamide (HOPhBenz) and its semicarbazone (HOPhBenz.SCZH) and thiosemicarbazone (HOPhBenz.TSCZH) are described. These derivatives were prepared by the reactions of 2-isopropoxy-4-methyl-1,3,2-dioxaborolane, and 2-isopropoxy-4-methyl-1,3,2-dioxaborinane with 2-hydroxy-N-phenylbenzamide, 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarboxamide (HOPhBenz.SCZH), and 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarbothioamide(HOPhBenz.TSCZH) in a 1:1 molar ratio. In order to assess the increase of the inhibitor potency, (HOPhBenz), (HOPhBenz.SCZH), (HOPhBenz.TSCZH) and their boron complexes have been tested in vitro against a number of pathogenic fungi and bacteria at different concentrations and were found to possess remarkable fungicidal and bactericidal properties. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs are discussed.

scholarly journals Antimicrobial, Antifertility and Antiinflammatory Approach to Tetradentate Macrocyclic Complexes of Iron(II) and Manganese(II)

2002 ◽  
Vol 8 (6) ◽  
pp. 347-353 ◽  
Author(s):  
Ashu Chaudhary ◽  
D. P. Jaroli ◽  
R. V. Singh
Keyword(s):  
Molecular Weight ◽  
Reproductive Organs ◽  
Spectral Studies ◽  
Central Metal Atom ◽  
Central Metal ◽  
Testicular Sperm ◽  
Mass Spectral ◽  
Sperm Density ◽  
Elemental Analyses

Some antifertility inhibitors of 18 to 24-membered tetraazamacrocyclic complexes of iron(II) and manganese(II) have been synthesised by the template condensation using 1,3-phenylenediamine with malonic acid, succinic acid, glutaric acid and adipic acid. The reaction proceed smoothly to completion. The complexes were characterized by elemental analyses, molecular weight determinations, infrared, electronic, magnetic moment, mössbaur and mass spectral studies. The elemental analyses are consistent with the formation of the complexes [M(N4Ln)Cl2] (M = Fe(lI) or Mn(II)). All these complexes are stable and monomeric in nature as indicated by the molecular weight determinations. The spectral studies confirm the octahedral geometry around the central metal atom. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs have been examined and discussed.

scholarly journals Template synthesis of macrocyclic complexes of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II): Spectroscopic, antibacterial and antifungal studies

2010 ◽  
Vol 75 (6) ◽  
pp. 763-772 ◽  
Author(s):  
Dharam Singh ◽  
Vandna Malik ◽  
Ramesh Kumar ◽  
Krishan Kumar
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Metal Ion ◽  
Inhibitory Concentration ◽  
Condensation Reaction ◽  
Carbonyl Oxygen ◽  
Macrocyclic Complexes ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
Divalent Metal Ions

A new series of macrocyclic complexes of the type [M(C17H14N4O2)X2], where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and X = Cl-, NO3-, CH3COO-was synthesized by the condensation reaction of malonyldihydrazide with benzil in the presence of divalent metal ions. The complexes were characterized with the aid of elemental analyses, conductance measurements, magnetic susceptibilities, electronic, NMR and infrared spectral studies. On the basis of these studies, a six coordinate distorted octahedral geometry, in which two nitrogen and two carbonyl oxygen atoms are suitably placed for coordination towards metal ion, is proposed for all the complexes. The complexes were tested for their in vitro antibacterial activity and antifungal activities. The minimum inhibitory concentration shown by these complexes were compared with the minimum inhibitory concentration shown by standard drugs.

scholarly journals Fertility Inhibitor Heterobimetallic Complexes of Platinum(II) and Palladium(II): Synthetic, Spectroscopic and Antimicrobial Aspects

2000 ◽  
Vol 7 (2) ◽  
pp. 105-113 ◽  
Author(s):  
Kripa Sharma ◽  
S. C. Joshi ◽  
R. V. Singh
Keyword(s):  
Sperm Morphology ◽  
Pathogenic Fungi ◽  
Reproductive Organs ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Testicular Sperm ◽  
Heterobimetallic Complexes ◽  
Sperm Density ◽  
Square Planar ◽  
Elemental Analyses

Synthetic, spectroscopic and antimicrobial aspects of some fertility inhibitor heterobimetallic complexes have been carried out. These heterobimetallic chelates [M(C5H5N3)2M2'(R)4]Cl2 (M = Pd or Pt and M' = Si, Sn, Ti and Zr) have been successfully synthesinzed via the reaction of M(C5H7N3)2Cl2 with group four or fourteen dichlorides in 1:2 stoichiometric proportions. The products were characterized by elemental analyses, molecular weight determinations, magnetic susceptibility measurements, conductance, and IR multinuclear NMR and electronic spectral studies. A square planar geometry has been suggested for all the complexes with the help of spectral data. Conductivity data strongly suggest that chlorine atoms are ionic in nature due to which complexes behave as electrolytes. All the complexes have been evaluated for their antmicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.

scholarly journals Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Nickel and Copper Complexes of Bis(thiosemicrbazone)

2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Sulekh Chandra ◽  
Smriti Raizada ◽  
Monika Tyagi ◽  
Archana Gautam
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Copper Complexes ◽  
Free Ligand ◽  
Antimicrobial Properties ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Central Metal ◽  
Antimicrobial Studies

A series of metal complexes of Cu(II) and Ni(II) having the general composition[M(L)X2]with benzil bis(thiosemicarbazone) has been prepared and characterized by element chemical analysis, molar conductance, magnetic susceptibility measurements, and spectral (electronic, IR, EPR, mass) studies. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. On the basis of spectral studies, an octahedral geometry has been assigned for Ni(II) complexes but a tetragonal geometry for Cu(II) complexes. The free ligand and its metal complexes have been tested in vitro against a number of microorganisms in order to assess their antimicrobial properties.

Infrared, 1H-NMR Spectral Studies of some Methyl 6-O-Myristoyl-α-D-Glucopyranoside Derivatives: Assessment of Antimicrobial Effects

2015 ◽  
Vol 58 ◽  
pp. 122-136 ◽  
Author(s):  
Sarkar M.A. Kawsar ◽  
Khaleda Mymona ◽  
Refat Asma ◽  
Mohammad A. Manchur ◽  
Yasuhiro Koide ◽  
...  
Keyword(s):  
Pathogenic Fungi ◽  
Spectral Studies ◽  
Bacterial Strains ◽  
Substitution Product ◽  
Antifungal Activities ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Fungal Phytopathogens ◽  
Antibacterial And Antifungal

This study was carried out to regioselective myristoylation of methyl α-D-glucopyranoside (1) using the direct acylation method gave the corresponding methyl 6-O-myristoyl-α-D-glucopyranoside (2) in fair yield. A number of 2,3,4-tri-O-acyl derivatives (3-15) of this 6-O-substitution product using a wide variety of acylating agents were also prepared in order to obtain newer derivatives of synthetic and biological importance. The reaction conditions are reasonably simple and yields were very good. The structures of the title compounds (2-15) were established by using analytical, physicochemical techniques and spectroscopic data (IR and 1H-NMR). All the synthesized compounds were employed as test chemicals for in vitro antimicrobial functionality test against Gram-positive Bacillus subtilis, Staphylococcus aureus, Gram-negative Escherichia coli, Pseudomonas aeruginosa bacteria and plant pathogenic fungi Aspergillus niger and Candida albicans. For comparative studies, antimicrobial activity of standard antibiotics, Ampicillin and Nystatin were also carried out against these microorganisms. The study revealed that the tested samples exhibited moderate to good antibacterial and antifungal activities. It was also observed that the test substances were more effective against fungal phytopathogens than those of the human bacterial strains. Encouragingly, a number of tested chemicals showed nearest antibacterial and antifungal activities with the standard antibiotics employed.

scholarly journals Synthesis and Spectroscopic and Biological Activities of Zn(II) Porphyrin with Oxygen Donors

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Gauri Devi Bajju ◽  
Sujata Kundan ◽  
Madhulika Bhagat ◽  
Deepmala Gupta ◽  
Ashu Kapahi ◽  
...  
Keyword(s):  
Metal Ion ◽  
Human Cancer ◽  
Biological Activities ◽  
Thermal Studies ◽  
Blue Shift ◽  
Biological Evaluation ◽  
Axial Ligand ◽  
Molar Ratio ◽  
Central Metal

Results of investigation of the physicochemical properties of zinc complexes containing substituted phenols as axial ligand having general formula [X-Zn-t(p-CH3) PP] [where X = different phenolates as axial ligand] in impurity-free organic solvent are presented. The four-coordinated zinc porphyrin accepts one axial ligand in 1 : 1 molar ratio to form five-coordinated complex, which is purified by column chromatography and characterized by physicochemical, biological evaluation and TGA/DTA studies. Absorption spectra show two principal effects: a red shift for phenols bearing substituted electron releasing groups (−CH3, −NH2) and blue shift for phenols bearing electron withdrawing groups (−NO2, −Cl) relative to Zn-t(p-CH3) PP, respectively.1H NMR spectra show that the protons of the phenol ring axially attached to the central metal ion are merged with the protons of the porphyrin ring. Fluorescence spectra show two fluorescence peaks in the red region with emission ranging from 550 nm to 700 nm. IR spectra confirm the appearance of Zn-NPorand Zn-O vibrational frequencies, respectively. According to the thermal studies, the complexes have a higher thermal stability and the decomposition temperature of these complexes depends on the axial ligation. The respective complexes of X-ZnII-t(p-CH3) PP were found to possess higher antifungal activity (up to 90%) and higherin vitrocytotoxicity against human cancer cells lines.

scholarly journals Synthesis and Antimicrobial Studies of novel metal complexes of testosterone thiosemicarbazone and methandrostenolon thiosemicarbazone

2010 ◽  
Vol 4 (1) ◽  
pp. 73-84
Author(s):  
Redha I. Al-Bayati ◽  
Ahmed AbdulAmier ◽  
Hussain Al-Amiery ◽  
Yasmien K. Al-Majedy
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Magnetic Moments ◽  
Antimicrobial Properties ◽  
Molar Ratio ◽  
Central Metal ◽  
Chemical Structures ◽  
Antimicrobial Studies ◽  
Number Of Microorganisms

This work involves the chemical synthesis of novel complexes derived from steroid hormones using testosterone and methandrostenolon as starting materials. When these starting materials react with thiosemicarbazide, L1 (testosteronthiosemicarbazone ) and L2 (methandrostenolonthiosemicarbazone ) are formed, and when they react with Cr (III), Co (II), Ni (II), and Cu (II) metal ions a new complexes are formed. The chemical structures for all the prepared compounds were characterized by elemental analysis, FT-IR, and UV/visible spectra. Moreover molar ratio M:L, metal content M%, and magnetic moments (μeff.) were also determined. The IR spectral data suggest the involvement of sulphur and azomethane nitrogen in coordination to the central metal ion. The free ligands and their metal complexes have been tested in vitro against a number of microorganisms (gram positive bacteria (Staphylococcus aureus), and gram negative bacteria (E. coli, Proteus vulgaris, Pseudomonas, and Klebsiella) in order to assess their antimicrobial properties. All the prepared complexes showed considerable activity against all bacteria.

scholarly journals Chemical Synthesis, Spectral Characterization and Biological Investigations of Novel Triazole-Based Schiff Base Ligand and its Transition Complexes

2020 ◽  
Vol 9 (3) ◽  
pp. 1372-1388
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Radical Scavenging ◽  
Positive Control ◽  
Negative Control ◽  
In Vitro Assays ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Radical Scavenging Ability

The present work describes the synthesis and characterization of a Schiff base 5-((3,4-dimethoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol (L) derived from 5-amino-4H-1,2, 4-triazole-3-thiol and 3,4-dimethoxy benzaldehyde and its Co(II), Cu(II), Ni(II) and Zn(II) complexes in 2:1 molar ratio (L:M). All the compounds were characterized using mass spectroscopy, 1H NMR, IR spectroscopy, UV-Visible spectroscopy, and TGA. In addition to theses spectral studies, DFT calculations have done. The Schiff base ligand and its complexes were assessed for their in vitro antibacterial activity against nine food pathogens, and their potential activity was qualitatively and quantitatively assessed by the presence/absence for the zone of inhibition and MIC values by taking standard antibiotic amoxicillin as positive control and DMSO as a negative control. The free radical scavenging ability of all the samples was assessed by employing a series of in vitro assays viz., DPPH, ABTS, and Superoxide, whereas BHA was used as a positive control and results were expressed as EC50 values. In vitro α-amylase, inhibitory studies revealed that complexes had effective inhibitory potential than the ligand. The synthesized compounds were virtually sketched, and the Docking operation was performed by using the SERFLEXDOCK program as a part of the SYBYL-X 2.1.1 software package (Tripos, USA).

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