scholarly journals Clinical significance of serum 25OHD level in patients with Crohn's disease

2016 ◽  
Vol 24 (17) ◽  
pp. 2737
Author(s):  
Jia-Jia Wang ◽  
Qiao-Min Wang
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Significance ◽  
25Ohd Level ◽  
Serum 25Ohd ◽  
Serum 25Ohd Level

scholarly journals P274 The clinical significance of anastomotic ulcers after ileocolic resection to predict postoperative recurrence of Crohn’s disease

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S288-S288
Author(s):  
J Y Kim ◽  
S H Park ◽  
Y J Kim ◽  
J C Park ◽  
S Noh ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Significance ◽  
Multivariable Analysis ◽  
Postoperative Recurrence ◽  
Ileocolic Resection ◽  
Single Centre ◽  
Endoscopic Recurrence ◽  
Endoscopic Remission

Abstract Background The Rutgeerts score (RS) is used to predict postoperative recurrence in Crohn’s disease (CD) patients after ileocolic resection primarily based on endoscopic finding at the neoterminal ileum. However, assessing anastomotic ulcers (AUs) is still a matter of debate. Our aim was to investigate the clinical significance of AUs on endoscopic recurrence in postoperative CD patients. Methods This was a single-centre retrospective study analysing postoperative CD patients with the RS of i0 to i1 at the first ileocolonoscopy within 1 year after ileocolic resection between 2000 and 2016 and those who underwent subsequent ileocolonoscopic follow-up. The study outcome was the clinical significance of AUs predicting endoscopic recurrence (RS ≥ i2b). Results Among 116 patients who were in endoscopic remission at the index postoperative ileocolonoscopy, 84.5% (98/116) underwent subsequent ileocolonoscopies. During the 30.0 months (interquartile ranges, 21.3–53.3) of median follow-up periods after the index ileocolonoscopy, 56.1% (55/98) showed endoscopic recurrence. Furthermore, 65.8% (48/73) with AUs and 75.5% (40/53) with major AUs defined as ulcer occupying ≥ 1/4 of the circumference or ≥ 3 ulcers confined to anastomotic ring, or any ulcers extended to ileocolic mucosa showed endoscopic recurrence. On multivariable analysis, the presence of AUs (adjusted hazard ratio [aHR], 4.33; 95% confidence interval [CI], 1.87–10.0; p < 0.001) and major AUs (aHR, 3.64; 95% CI, 1.95–6.79; p < 0.001) were associated with endoscopic recurrence, respectively. Conclusion AUs are associated with a significantly higher risk of endoscopic recurrence in postoperative CD patient who are in endoscopic remission.

scholarly journals Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xiufang Cui ◽  
Chunhua Jiao ◽  
Di Wang ◽  
Ziping Ye ◽  
Jingjing Ma ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Clinical Significance ◽  
Activity Index ◽  
Biological Marker ◽  
Disease Activity Index ◽  
Serum Levels ◽  
Th1 Cells ◽  
Control Subjects

Immune disorders play an important role in the pathogenesis of Crohn’s disease (CD). Notably, the increased immune response of Th1 cells and related cytokines is associated with the onset of CD. IL-27 is a newly discovered IL-12-related cytokine, but its expression and clinical significance in CD patients are still controversial. This study is aimed at evaluating the serum levels of IL-27 in CD patients and analyzing their clinical significance. The results indicated that serum levels of IL-27 in CD patients were significantly higher than those in control subjects (median (interquartile range (IQR)): 110.0 (95.0, 145.0) vs. 85.0 (80.0, 95.0) pg/ml, P < 0.001 ). Furthermore, the IL-27 levels significantly increased in CD patients at the active stage compared with CD patients in remission (CDR) (127.5 (100.0, 150.0) vs. 90 (80.0, 110.0) pg/ml, P < 0.001 ). However, there was no difference in IL-27 levels between CDR and control subjects. The levels of IL-27 were positively correlated with Crohn’s disease activity index (CDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fecal calprotectin (FC), and Simple Endoscopic Score for Crohn’s Disease (SES-CD) and negatively correlated with hemoglobin (Hb) and serum albumin (ALB). IL-27 combined with CRP favored the prediction of CD activity (area under the curve (AUC): 0.88). Additionally, the proportions of Th17 and Th1 cells in peripheral blood were higher in CD patients than in control subjects. Active CD patients exhibited significantly higher proportions of Th17 and Th1 cells than those in remission. Moreover, correlation analysis indicated that the serum levels of IL-27 were positively associated with the frequency of Th17 cells in CD patients ( r = 0.519 , P = 0.013 ) but not associated with the frequency of Th1 cells in CD patients. IL-27 is positively associated with multiple inflammation indicators and may exert a proinflammatory profile by regulating Th17 cell differentiation in the development of Crohn’s disease. In the future, IL-27 combined with CRP is expected to become an important biological marker of CD activity.

scholarly journals Limitations of platform assays to measure serum 25OHD level impact on guidelines and practice decision making

Metabolism ◽  
2018 ◽  
Vol 89 ◽  
pp. 1-7 ◽  
Author(s):  
Maya Rahme ◽  
Laila Al-Shaar ◽  
Ravinder Singh ◽  
Rafic Baddoura ◽  
Georges Halaby ◽  
...  
Keyword(s):  
Decision Making ◽  
25Ohd Level ◽  
Serum 25Ohd ◽  
Serum 25Ohd Level

scholarly journals P266 Clinical significance of granulomas in Crohn’s disease: a meta-analysis

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S231-S232
Author(s):  
S W Hong ◽  
H Yoon ◽  
C M Shin ◽  
Y S Park ◽  
N Kim ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Significance ◽  
Meta Analysis

scholarly journals Practice patterns and clinical significance of use of capsule endoscopy in suspected and established Crohn's disease

2017 ◽  
Vol 15 (4) ◽  
pp. 467 ◽  
Author(s):  
Yonghyun Kim ◽  
Seong Ran Jeon ◽  
Sang Myung Choi ◽  
Hyun Gun Kim ◽  
Tae Hee Lee ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Significance ◽  
Capsule Endoscopy ◽  
Practice Patterns

scholarly journals Autophagy: A Primer for the Gastroenterologist/Hepatologist

2011 ◽  
Vol 25 (12) ◽  
pp. 667-674 ◽  
Author(s):  
Christiane Sokollik ◽  
Michelle Ang ◽  
Nicola L Jones
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Present Article ◽  
Clinical Significance ◽  
Gastrointestinal Disease ◽  
Therapeutic Option ◽  
Eukaryotic Cells ◽  
Diverse Range ◽  
Cellular Pathway ◽  
Autophagy Pathway

Autophagy is a conserved cellular pathway that maintains intracellular homeostasis by degrading proteins and cytosolic contents of eukaryotic cells. Autophagy clears misfolded and long-lived proteins, damaged organelles and invading microorganisms from cells, and provides nutrients and energy in response to exposure to cell stressors such as starvation. Defective autophagy has recently been linked to a diverse range of disease processes of relevance to gastroenterologists and hepatologists including Crohn’s disease, pancreatitis, hepatitis and cancer. The present article provides an overview of the autophagy pathway and discusses gastrointestinal disease processes in which alterations in autophagy have been implicated. The clinical significance of autophagy as a potential therapeutic option is also discussed.

scholarly journals Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn’s disease

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Adi Lahat ◽  
◽  
Uri Kopylov ◽  
Sandra Neuman ◽  
Nina Levhar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Significance

scholarly journals Vitamin D Deficiency Is Associated with Endoscopic Severity in Patients with Crohn’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Lingna Ye ◽  
Ziwen Lin ◽  
Jing Liu ◽  
Qian Cao
Keyword(s):  
Vitamin D ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Activity Index ◽  
Disease Activity Index ◽  
Vitamin D Status ◽  
Serum 25Ohd ◽  
Vitamin D Levels

Background and Aims. Vitamin D deficiency is common in patients with Crohn’s disease and is associated with disease activity. Relationship between vitamin D and endoscopic disease activity is unknown. The aim of the study is to determine the association between vitamin D status and endoscopic disease activity in CD patients.Methods. Consecutive hospitalized CD patients from 2014 to 2016 who received vitamin D assessment and colonoscopy were retrospectively evaluated. Clinical disease activity was assessed by Crohn’s disease activity index and C-reactive protein. Endoscopic activity was calculated using simple endoscopic score for Crohn’s disease.Results. Median serum 25OHD level of 131 patients was lower than healthy controls [21.1 nmol/L (11.8–32.3) versus 49.9 nmol/L (44.9–57.4),P=0.007]. 125 (95%) patients had vitamin D deficiency and the rest (5%) had vitamin D insufficiency. Serum 25OHD was inversely correlated with CRP (r=−0.308,P<0.001), CDAI (r=−0.582,P<0.001), SES-CD (r=−0.294,P=0.001), and endoscopic severity stratified by SES-CD (P=0.001).Conclusion. Vitamin D deficiency was prevalent among hospitalized CD patients. Vitamin D levels were inversely correlated with endoscopic disease activity. Vitamin D status could be a biomarker in assessing disease activity among hospitalized CD patients in addition to CDAI and CRP.

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