Application value of serum pepsinogen and gastrin-17 in screening gastric precancerous lesions

Abstract Background The aim of this study is to investigate the difference of serum pepsinogen (PG) baseline levels in different regions of China and its influencing factors. Methods From October 2016 to October 2018, asymptomatic health checkup people who underwent nasal endoscopy in nine health management centers in different regions of China were collected. Lifestyle questionnaires were conducted, and serum PG and gastroscopy were performed. The differences in PG levels in baseline population (OLGA-0 grade) were studied according to geographical subregions of China. SPSS software was used for statistical analysis. Results 1922 patients were included in the final analysis. Compared with the non-atrophy (OLGA-0) group, PGR levels in atrophy group (OLGA-I to IV) were significantly decreased with the atrophy degree (p < 0.05). A total of 1590 baseline people (OLGA-0) were included in the study, including 254 from South China, 574 from East China, 210 from Southwest China, 332 from Northeast China, and 220 from Central/Northern China. There were significant differences in baseline PGI levels among the five regions (p < 0.05). The PGII levels were also different among the five regions, except for Central/Northern versus Southern China. PGR (PGI/PGII ratio) levels in Southern China were higher than other four regions. Further studies were conducted on the related factors that might affect the baseline PG level, which was affected by nationality, dietary habits, smoking, Helicobacter pylori infection and other related factors. Conclusion Influenced by many factors, the baseline PG levels are different in different regions of China. In the follow-up studies of PG cut-off value, different PG cut-off value based on region may be more effective in the screening of gastric cancer and precancerous lesions in China.

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How endoscopic findings may conceal gastric precancerous lesions? A study in a high-frequent area

European Journal of Cancer ◽

10.1016/s0959-8049(02)80066-1 ◽

2002 ◽

Vol 38 (11) ◽

pp. S51

Author(s):

J Mikaeli

Keyword(s):

Precancerous Lesions ◽

Endoscopic Findings

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Influence of pepsinogen gene polymorphisms on serum pepsinogen

Annals of Human Genetics ◽

10.1017/s0003480097005988 ◽

1997 ◽

Vol 61 (2) ◽

pp. 93-97 ◽

Cited By ~ 7

Author(s):

Z. YAMAGATA ◽

Y. ZHANG ◽

S. SHINOZAKI ◽

T. MIYAMURA ◽

S. IIJIMA ◽

...

Keyword(s):

Gene Polymorphisms ◽

Serum Pepsinogen

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The role of immunohistochemistry in the diagnosis of cervical intraepithelial neoplasia of different severity

HEALTH OF WOMAN ◽

10.15574/hw.2016.113.138 ◽

2016 ◽

pp. 138-140

Author(s):

S.I. Zhuk ◽

◽

O.A. Taran ◽

A.N. Koshmienskaya ◽

T.V. Lobastova ◽

...

Keyword(s):

Protein Expression ◽

Cervical Intraepithelial Neoplasia ◽

Precancerous Lesions ◽

Molecular Genetic ◽

Intraepithelial Neoplasia ◽

Reproductive Age ◽

Moderate Degree ◽

Ki 67 ◽

The Third ◽

Diagnosis And Prognosis

The objective: the finding of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia of different severity to optimize the diagnosis and prognosis of the disease. Patients and methods. The study involved 42 women of reproductive age with cervical intraepithelial the neoplasia of the cervix varying degrees applied to the doctor of cervical pathology Zhitomir regional oncologic dispensary. All women (n=42) were divided into groups. The first group included 15 patients (35.7%) with cervical intraepithelial neoplasia with mild. The second group included 13 women (31%) with cervical intraepithelial neoplasia a moderate degree. The third group was represented by patients with cervical intraepithelial neoplasia with severe – 14 respondents (33.3 per cent). Results. Marker BCL-2 in patients of the first group was positive in 7 patients (46.7%), Smooth Muscule Actin was positive in 9 patients (60%) and Ki-67 was diagnosed in 8 of the surveyed women (53.3%). In the second group of BCL-2 was positive in 8 patients (61.5%), Clone 124, Smooth Muscule Actin, Clone 1A4 was positive in 9 patients (69.2%), and Ki-67 was diagnosed in 12 of the surveyed women (92.3%). Marker BCL-2 in patients of the third group was positive in 12 patients (85.7%), Smooth Muscule Actin was positive in 10 patients (71.4%) and Ki-67 was diagnosed in 13 of the surveyed women (92.9% ). Conclusion. Carcinogenesis is associated with molecular genetic damage to the cervix. Some of the products of this process can be used as prognostic and diagnostic markers of tumor progression. Determination of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia makes it possible to accurately verify the diagnosis and to predict the course of pathological changes in the flat epithelium of the cervix. Key words: cervical intraepithelial neoplasia, cervical cancer, morphological diagnostics of precancerous lesions, BCL-2, Smooth Muscule Actin, Ki-67.

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Expedited Resolution of 5-Fluorouracil-Induced Erythema and Barrier Dysfunction with White Petrolatum

SKIN The Journal of Cutaneous Medicine ◽

10.25251/skin.3.4.9 ◽

2019 ◽

Vol 3 (4) ◽

pp. 279-282

Author(s):

Melody Maarouf ◽

Bryan Kromenacker ◽

Eric Brucks ◽

Vivian Shi

Keyword(s):

Squamous Cell Carcinoma ◽

Wound Healing ◽

Recovery Time ◽

Patient Adherence ◽

Precancerous Lesions ◽

Transepidermal Water Loss ◽

Petroleum Jelly ◽

Barrier Dysfunction ◽

Exposed Skin ◽

Risk Of Progression

Actinic keratoses (AK) are precancerous lesions that develop on chronically sun-exposed skin. They frequently require prophylactic field treatment due to the risk of progression to squamous cell carcinoma. Topical treatment with 5-fluorouracil (5-FU) yields near complete AK resolution, yet leaves a patient with an exuberant erythematous treatment site, which may be embarrassing and/or uncomfortable. We report a case of a patient with diffuse facial AK who was treated with 5-FU twice daily for 2 weeks, resulting in fiery-red erythema and disrupted barrier indices. Application of pure ultra white petroleum jelly, an emollient preferred by dermatologists for post-operative wound healing, resulted in drastic decreased erythema and recovery time of post-treatment transepidermal water loss and hydration, compared to the contralateral, non-petrolatum-treated side. Additionally, petrolatum use did not disrupt the AK resolution endpoint. We suggest that petroleum jelly be used for the repair of 5-FU-induced barrier disruption and erythema to promote greater patient adherence.

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