Abstract P2-14-06: Characterization of risk factors in breast cancer young adult patients

2013 ◽  
Author(s):  
G Encinas ◽  
MDPE Diz ◽  
EC Lyra ◽  
MLH Katayama ◽  
FS Pasini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Young Adult ◽  
Adult Patients

Characteristics and outcomes of acute COVID-19 infection in paediatric and young adult patients with underlying cardiac disease

2021 ◽  
pp. 1-7
Author(s):  
Joshua M. Fisher ◽  
Sarah Badran ◽  
John T. Li ◽  
Jodie K. Votava-Smith ◽  
Patrick M. Sullivan
Keyword(s):  
Risk Factors ◽  
Young Adult ◽  
Pulmonary Disease ◽  
Cardiac Disease ◽  
Single Ventricle ◽  
Cardiac Risk ◽  
Adult Patients ◽  
Chronic Pulmonary Disease ◽  
Cardiac Risk Factors ◽  
Increased Risk

Abstract Objective To describe outcomes of acute coronavirus disease 2019 in paediatric and young adult patients with underlying cardiac disease and evaluate the association between cardiac risk factors and hospitalisation. Study design We conducted a retrospective single-institution review of patients with known cardiac disease and positive severe acute respiratory syndrome coronavirus 2 RT-PCR from 1 March, 2020 to 30 November, 2020. Extracardiac comorbidities and cardiac risk factors were compared between those admitted for coronavirus disease 2019 illness and the rest of the cohort using univariate analysis. Results Forty-two patients with a mean age of 7.7 ± 6.7 years were identified. Six were 18 years of age or more with the oldest being 22 years of age. Seventy-six percent were Hispanic. The most common cardiac diagnoses were repaired cyanotic (n = 7, 16.6%) and palliated single ventricle (n = 7, 16.6%) congenital heart disease. Fourteen patients (33.3%) had underlying syndromes or chromosomal anomalies, nine (21%) had chronic pulmonary disease and eight (19%) were immunosuppressed. Nineteen patients (47.6%) reported no symptoms. Sixteen (38.1%) reported only mild symptoms. Six patients (14.3%) were admitted to the hospital for acute coronavirus disease 2019 illness. Noncardiac comorbidities were associated with an increased risk of hospitalisation (p = 0.02), particularly chronic pulmonary disease (p = 0.01) and baseline supplemental oxygen requirement (p = 0.007). None of the single ventricle patients who tested positive required admission. Conclusions Hospitalisations for coronavirus disease 2019 were rare among children and young adults with underlying cardiac disease. Extracardiac comorbidities like pulmonary disease were associated with increased risk of hospitalisation while cardiac risk factors were not.

Detailed assessment and risk factor analysis of corticosteroid-induced psychiatric disorders in pediatric, adolescent, and young adult patients undergoing induction or consolidation therapy for hematologic malignancy

2019 ◽  
Vol 26 (5) ◽  
pp. 1041-1051
Author(s):  
Yukiko Staub ◽  
Yukio Suga ◽  
Yasuhiro Ikawa ◽  
Kiyotaka Tsubouchi ◽  
Mikie Hashimoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adult ◽  
Psychiatric Disorders ◽  
Treatment Regimen ◽  
Behavioral Problems ◽  
Developmental Process ◽  
Hematologic Malignancy ◽  
Adult Patients ◽  
Adolescent And Young Adult ◽  
Emotional And Behavioral Problems

Background Corticosteroid-induced psychiatric disorders (CIPDs) represent an adverse effect that can cause severe emotional and behavioral problems. The aim of the present study was to assess the incidence and risk factors of CIPDs. Methods A retrospective analysis of 92 pediatric and young adult patients with hematologic malignancies was conducted. Results The incidence of CIPDs in patients receiving a treatment regimen with prednisolone or dexamethasone was 64.9% and 77.5%, respectively, both of which were significantly higher than that in patients not receiving corticosteroids. Independent risk factors and adjusted odds ratios (95% confidence intervals) related to severe CIPD were 2.15 (1.11–4.18) for dexamethasone (using prednisolone as the reference) and 0.81 (0.75–0.87) for age, suggesting that the odds increase with decreasing age. Frequently observed symptoms, respectively in terms of behavioral and emotional problems were defiance, crying, psychomotor excitement, dysphoria, irritability, and depression. To our knowledge, this is the first report to mention the risk factors and characteristics for clinical symptoms of CIPDs during the developmental process. Conclusions Healthcare professionals should predict and prepare for psychiatric adverse events prior to chemotherapy in the clinical settings, especially in patients in younger age and receiving a treatment regimen with dexamethasone.

scholarly journals Systematic Review on Knowledge and Awareness of Breast Cancer and Risk Factors Among Young Women

2019 ◽  
Vol 7 (1) ◽  
pp. 41
Author(s):  
Aeshah Hamdan Almutairi ◽  
Shamsul Bahri Bin Md Tamrin ◽  
Rahmita Wirza ◽  
Norliza Binti Ahmad
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Young Adult ◽  
Young Women ◽  
Detection Methods ◽  
Primary Study ◽  
Adult Women ◽  
Young Adult Women ◽  
Cancer Symptoms

Introduction: Breast cancer is considered the primary cancer to affect women according to the global context. Due to its crucial escalation, it has become vital to inform the general population regarding breast cancer symptoms, risk factors and earlier detection methods. The main aim of the present study is to conduct a systematic review of breast cancer and the risk factors affecting young adult women. Methods: A systematic literature review was carried out to garner global studies on breast cancer risk factors as well as to understand the degree to which breast cancer and its associated risk factors are understood. The primary study included the exploration of databases and journal websites, PubMed, Google Scholar and Medline. The articles studied for the review was focused on the printed original English articles from the year 2008 to December, 2017. This review highlights the necessity for further studies regarding knowledge of breast cancer and its risk factors among young adult women are understood. Conclusion: Knowledge about breast cancer and its risk factors among young women was inadequate. Furthermore, cultural sensitivities should be adjusted to ensure optimal awareness among the public, in particular teenagers and young adult women. Intensive educational campaigns should be planned to increase breast cancer awareness in order to minimize the observed deficit of knowledge. The role of prevention and procedures to screen breast examinations in clinics as well as mammography should all be highlighted in order to achieve these goals and obtain the required data.

scholarly journals Early Cardiac Function Monitoring for Detection of Subclinical Doxorubicin Cardiotoxicity in Young Adult Patients with Breast Cancer

2013 ◽  
Vol 16 (2) ◽  
pp. 178 ◽  
Author(s):  
Woo-Baek Chung ◽  
Jeong-Eun Yi ◽  
Jung Yeon Jin ◽  
Yun-Seok Choi ◽  
Chan Seok Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Adult ◽  
Cardiac Function ◽  
Adult Patients ◽  
Doxorubicin Cardiotoxicity

Risk factors of sudden death in young adult patients with myelomeningocele

2012 ◽  
Vol 9 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Sarah C. Jernigan ◽  
Jay G. Berry ◽  
Dionne A. Graham ◽  
Stuart B. Bauer ◽  
Lawrence I. Karlin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Sleep Apnea ◽  
Young Adult ◽  
Sudden Death ◽  
Adult Patients ◽  
Csf Shunt ◽  
Study Cohort ◽  
Fisher Exact Test ◽  
Adult Women ◽  
Increased Risk

Object Although survival for patients with myelomeningocele has dramatically improved in recent decades, the occasional occurrence of sudden, unexplained death in young adult patients with myelomeningocele has been noted by the authors. This study was undertaken to determine risk factors for sudden death in this population. Methods The authors performed a retrospective chart review of patients born between 1978 and 1990 who received care at Children's Hospital Boston. The relationship between sudden death and patient demographics, presence of CSF shunt and history of shunt revisions, midbrain length as a marker for severity of hindbrain malformation, seizures, pulmonary and ventilatory dysfunction, body mass index, scoliosis, renal dysfunction, and cardiac disease was evaluated using the t-test, Fisher exact test, and logistic regression analysis. Results The age range for 106 patients in the study cohort was 19–30 years, with 58 (54.7%) women and 48 (45.3%) men. Six patients, all of whom were young women, experienced sudden death. In multivariate analysis, female sex, sleep apnea, and midbrain elongation ≥ 15 mm on MR imaging remained significantly associated with a higher risk of sudden death. These risk factors were cumulative, and female patients with sleep apnea and midbrain length ≥ 15 mm had the greatest risk (adjusted risk ratio 24.0, 95% CI 7.3–79.0; p < 0.05). No other comorbidities were found to significantly increase the risk of sudden death. Conclusions Young adult women with myelomeningocele are at significantly increased risk of sudden death in the setting of midbrain elongation and sleep apnea. Further investigation is needed to determine the benefit of routine screening to identify at-risk patients for closer cardiopulmonary monitoring and treatment.

Evaluating risk factors for violence at the inpatient unit level: combining young adult patients and those with mental retardation

2005 ◽  
Vol 18 (2) ◽  
pp. 117-121 ◽  
Author(s):  
James P. LePage ◽  
Melanie McGhee ◽  
Ahmed Aboraya ◽  
James Murphy ◽  
Linda VanHorn ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mental Retardation ◽  
Young Adult ◽  
Inpatient Unit ◽  
Adult Patients ◽  
Unit Level

scholarly journals Vancomycin-Associated Acute Kidney Injury in Critically Ill Adolescent and Young Adult Patients

2019 ◽  
Vol 33 (6) ◽  
pp. 749-753 ◽  
Author(s):  
William B. Hays ◽  
Emma Tillman
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Young Adult ◽  
Critically Ill ◽  
Kidney Injury ◽  
Adult Patients ◽  
Adolescent And Young Adult ◽  
Daily Dose ◽  
Vancomycin Trough ◽  
Trough Levels

Background: Risk factors for the development of vancomycin-associated acute kidney injury (AKI) have been evaluated in both pediatric and adult populations; however, no previous studies exist evaluating this in the critically ill adolescent and young adult patients. Objective: Identify the incidence of AKI and examine risk factors for the development of AKI in critically ill adolescents and young adults on vancomycin. Methods: This retrospective review evaluated the incidence of AKI in patients 15 to 25 years of age who received vancomycin, while admitted to an intensive care unit. Acute kidney injury in this population was defined as an increase in serum creatinine by 0.5 mg/dL or 50% from baseline. Patients who developed AKI were evaluated for specific risk factors compared to those who did not develop AKI. Results: A total of 50 patients (20 developed AKI) were included in the study. There was no difference in vancomycin daily dose or duration of vancomycin therapy. Maximum vancomycin trough (31.15 mg/dL vs 12.5 mg/dL, P = .006), percentage of patients with concurrent nephrotoxic medication (95% vs 60%, P = .012) and concurrent vasopressor (55% vs 23%, P = .029) were higher in those who developed AKI. Percentage of patients who underwent a procedure while on vancomycin (35% vs 6.7%, P = .021) was also higher within the AKI group. Conclusions: Vancomycin-associated AKI occurred in 40% of critically ill adolescent and young adult patients. These patients may be more likely to develop vancomycin-associated AKI if they had undergone a procedure, as well as in the presence of high vancomycin trough levels, concurrent nephrotoxic agents, and concurrent vasopressor therapy.

scholarly journals Risk Factors of Breast Cancer Among Western Algerian Women Under 40 years’ old

2021 ◽  
Vol 6 (3) ◽  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Young Adult ◽  
Multivariable Analysis ◽  
Oral Contraception ◽  
Adult Women ◽  
Young Adult Women ◽  
Nulliparous Women ◽  
Increased Risk ◽  
Western Algeria

Background: The frequency of patients developing Breast Cancer (BC) among all other types of cancers exceeds 35% in Western Algeria. The main objective here was to determine which risk factors were associated with this high frequency of BC occurrence in young adult women (<40 years old) in Western Algeria. Methods: A BC case-control study matching with the woman age was conducted. The total number of participants was 484 women from Western Algeria. Inclusion criteria were BC and age <40 and women older than 40 or without documented BC were excluded. Results: Univariable analysis showed that i) there was an increased risk of BC; OR = 1.77 [1.06 to 2.93] in married women using oral contraception drugs; ii) in contrast there was a lesser risk; OR = 0.43 [0.28 to 0.65] of BC in multiparous compared to nulliparous women; iii) similarly there was a lesser risk; OR = 0.45 [0.26 to 0.76] of BC in married, divorced and widowed women compared to single women. Multivariable analysis showed a higher risk; OR = 2.34 [1.05 to 5.22] of BC in non-breastfeeding than lactating women. Conclusion: The use of oral contraception drugs, nulliparity, lack of breastfeeding and the single unmarried status are risk factors associated with increased BC in young adult women (<40) from Western Algeria.

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