Abstract A36: The relationship between modifiable environmental risk factors and colorectal cancer: A systematic review

Abstract Dementia-related missing incidents are a highly prevalent issue worldwide. Despite being associated with potentially life-threatening consequences, very little is still known about what environmental risk factors may potentially contribute to these missing incidents. The aim of this study was to conduct a retrospective, observational analysis using a large sample of police case records of missing individuals with dementia (n = 210). Due to the influence that road network structure has on our real world navigation, we aimed to explore the relationship between road intersection density, intersection complexity, and orientation entropy to the dementia-related missing incidents. For each missing incident location, the above three variables were computed at a 1 km radius buffer zone around these locations; these values were then compared to that of a set of random locations. The results showed that higher road intersection density, intersection complexity, and orientation entropy were all significantly associated with dementia-related missing incidents. Our results suggest that these properties of road network structure emerge as significant environmental risk factors for dementia-related missing incidents, informing future prospective studies as well as safeguarding guidelines.

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The Chinese National Twin Registry: An Update

Twin Research and Human Genetics ◽

10.1017/thg.2012.148 ◽

2013 ◽

Vol 16 (1) ◽

pp. 86-90 ◽

Cited By ~ 19

Author(s):

Liming Li ◽

Wenjing Gao ◽

Canqing Yu ◽

Jun Lv ◽

Weihua Cao ◽

...

Keyword(s):

Risk Factors ◽

Chronic Diseases ◽

Environmental Risk ◽

Population Based ◽

Environmental Risk Factors ◽

Twin Registry ◽

The Relationship ◽

Discordant Twin

The Chinese National Twin Registry (CNTR), established in 2001, is the first and largest population-based twin registry in China. Based on the CNTR, a new twin cohort was recruited from 2011 to study the relationship between environmental risk factors and chronic diseases. So far, 33,874 twin pairs from nine provinces have been recruited, in which hundreds of disease-discordant twin pairs and even thousands of exposure-discordant twin pairs were found in this cohort. The updates of the CNTR will be introduced in detail in this article.

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Environmental Risk Factors for Bipolar Disorders and High-Risk States in Adolescence: A Systematic Review

Medicina ◽

10.3390/medicina56120689 ◽

2020 ◽

Vol 56 (12) ◽

pp. 689

Author(s):

Giulia Menculini ◽

Pierfrancesco Maria Balducci ◽

Luigi Attademo ◽

Francesco Bernardini ◽

Patrizia Moretti ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

High Risk ◽

Environmental Risk ◽

Stressful Life Events ◽

Treatment Strategies ◽

Bipolar Disorders ◽

Environmental Risk Factors ◽

Newcastle Ottawa Scale ◽

Present Systematic Review

Background and objectives: A deeper comprehension of the role that environmental risk factors play in the development of adolescent Bipolar Disorder (BD), as well as in the evolution of high-risk states for BD, may entangle further prevention and treatment advances. The present systematic review is aimed at critically summarizing evidence about the role that environmental risk factors play in the development of BD in adolescence and their interaction with BD high-risk states. Materials and Methods: MEDLINE/Pubmed, Scopus and Web of Science datasets were systematically searched until 4 September 2020. Original studies that reported information about the role of environmental risk factors in the development of BD during adolescence, or assessing their influence on the development of psychopathology in high-risk states for BD, were considered for inclusion. Two blind researchers performed title/abstract, full-text screening, and hand-screening of relevant references. The risk of bias was assessed by means of the Newcastle-Ottawa Scale. Results: Fourteen studies were included in the review. Negative stressful life events, particularly sexual and physical abuse, but also emotional mistreatment, were associated with more severe psychopathology in adolescents with BD, as well as with higher risk for developing mood disorders in BD offspring. Similar findings were detected for familial environment-related features, such as parental rejection and low perceived care, while no univocal results were found when analyzing familial functioning. Conclusions: The present systematic review confirmed the relevant role that environmental risk factors, particularly negative stressful live events and family-related features, play in the development of BD psychopathology during adolescence. Future studies are expected to clarify possible further environmental factors that may be implicated in the development of BD during youth that may serve as target of prevention and early treatment strategies.

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Environmental risk factors of leptospirosis in urban settings: a systematic review protocol

BMJ Open ◽

10.1136/bmjopen-2018-023359 ◽

2019 ◽

Vol 9 (1) ◽

pp. e023359

Author(s):

Mohd Hatta Abdul Mutalip ◽

Mohd Amierul Fikri Mahmud ◽

Noor Aliza Lodz ◽

Norzawati Yoep ◽

Eida Nurhadzira Muhammad ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Environmental Risk ◽

Observational Studies ◽

Data Extraction ◽

Meta Analysis ◽

Environmental Risk Factors ◽

Primary Data ◽

Urban Settings ◽

Susceptible Populations

IntroductionLeptospirosis is the most common zoonotic disease that causes morbidity and mortality worldwide. The disease can cause sporadic epidemics and recent epidemics have become more apparent in urban localities. There is lack of documented evidence on the specific risk factors of leptospirosis infection among the urbanites, thereby impeding initiatives for prevention in urban settings. We aim to systematically search published articles and synthesise evidence on the risk factors associated with leptospirosis infection among the susceptible populations in urban localities, particularly to identify the risk factors of non-recreational leptospirosis infection.Methods and analysisWe will conduct a systematic review of observational studies that investigated environmental risk factors of leptospirosis in urban localities. The search will be performed for any eligible articles from selected electronic databases from 1970 until May 2018. The study will include any studies that investigated risk factors of confirmed leptospirosis cases who acquired the infection in urban locality, particularly exposures from the non-recreational and non-water-related activities. Study selection and reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and Meta-Analysis of Observational Studies in Epidemiology guideline. All data will be extracted using a standardised data extraction form and quality of the studies will be assessed using the Newcastle-Ottawa Scale guideline. Descriptive and meta-analysis will be performed by calculating the standardised median ORs and risk ratios for types of the non-recreational risk factors stratified by social, living conditions and environmental exposures, types of reservoirs and transmissions and types of activities and employments associated with leptospirosis infection in urban locality.Ethics and disseminationNo primary data will be collected thus no formal ethical approval is required. The results will be disseminated though a peer-reviewed publication and conference presentation.PROSPERO registration numberCRD42018090820.

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Non-viral environmental risk factors for nasopharyngeal carcinoma: A systematic review

Seminars in Cancer Biology ◽

10.1016/j.semcancer.2012.01.009 ◽

2012 ◽

Vol 22 (2) ◽

pp. 117-126 ◽

Cited By ~ 92

Author(s):

Wei-Hua Jia ◽

Hai-De Qin

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Nasopharyngeal Carcinoma ◽

Environmental Risk ◽

Environmental Risk Factors

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Beyond genes: A systematic review of environmental risk factors in specific reading disorder

Research in Developmental Disabilities ◽

10.1016/j.ridd.2018.03.005 ◽

2018 ◽

Vol 82 ◽

pp. 147-152 ◽

Cited By ~ 10

Author(s):

Sara Mascheretti ◽

Chiara Andreola ◽

Simona Scaini ◽

Simone Sulpizio

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Environmental Risk ◽

Environmental Risk Factors ◽

Reading Disorder ◽

Specific Reading

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Occupational and environmental risk factors for chronic rhinosinusitis: a systematic review

International Forum of Allergy & Rhinology ◽

10.1002/alr.21573 ◽

2015 ◽

Vol 5 (11) ◽

pp. 996-1003 ◽

Cited By ~ 25

Author(s):

Agnes S. Sundaresan ◽

Annemarie G. Hirsch ◽

Margaret Storm ◽

Bruce K. Tan ◽

Thomas L. Kennedy ◽

...

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Chronic Rhinosinusitis ◽

Environmental Risk ◽

Environmental Risk Factors

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Delinquent Behavior: Systematic Review of Genetic and Environmental Risk Factors

Clinical Child and Family Psychology Review ◽

10.1007/s10567-019-00298-w ◽

2019 ◽

Vol 22 (4) ◽

pp. 502-526 ◽

Cited By ~ 1

Author(s):

Andreia Azeredo ◽

Diana Moreira ◽

Patrícia Figueiredo ◽

Fernando Barbosa

Keyword(s):

Risk Factors ◽

Systematic Review ◽

Environmental Risk ◽

Delinquent Behavior ◽

Environmental Risk Factors

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The Relationship Between the Genetic and Environmental Influences on Common Externalizing Psychopathology and Mental Wellbeing

Twin Research and Human Genetics ◽

10.1375/twin.14.6.516 ◽

2011 ◽

Vol 14 (6) ◽

pp. 516-523 ◽

Cited By ~ 19

Author(s):

Kenneth S. Kendler ◽

John M. Myers ◽

Corey L. M. Keyes

Keyword(s):

Risk Factors ◽

Environmental Risk ◽

Genetic Risk ◽

Genetic Risk Factors ◽

Environmental Risk Factors ◽

Mental Wellbeing ◽

Negatively Associated ◽

Externalizing Psychopathology ◽

Internalizing Psychopathology ◽

The Relationship

To determine the relationship between the genetic and environmental risk factors for externalizing psychopathology and mental wellbeing, we examined detailed measures of emotional, social and psychological wellbeing, and a history of alcohol-related problems and smoking behavior in the last year in 1,386 individual twins from same-sex pairs from the MIDUS national US sample assessed in 1995. Cholesky decomposition analyses were performed withthe Mx program. The best fit model contained one highly heritable common externalizing psychopathology factor for both substance use/abuse measures, and one strongly heritable common factor for the three wellbeing measures. Genetic and environmental risk factors for externalizing psychopathology were both negatively associated with levels of mental wellbeing and accounted for, respectively, 7% and 21% of its genetic and environmental influences. Adding internalizing psychopathology assessed in the last year to the model, genetic risk factors unique for externalizing psychopathology were now positively related to levels of mental wellbeing, although accounting for only 5% of the genetic variance. Environmental risk factors unique to externalizing psychopathology continued to be negatively associated with mental wellbeing, accounting for 26% of the environmental variance. When both internalizing psychopathology and externalizing psychopathology are associated with mental wellbeing, the strongest risk factors for low mental wellbeing are genetic factors that impact on both internalizing psychopathology and externalizing psychopathology, and environmental factors unique to externalizing psychopathology. In this model, genetic risk factors for externalizing psychopathology predict, albeit weakly, higher levels of mental wellbeing.

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