Beyond genes: A systematic review of environmental risk factors in specific reading disorder

2018 ◽  
Vol 82 ◽  
pp. 147-152 ◽  
Author(s):  
Sara Mascheretti ◽  
Chiara Andreola ◽  
Simona Scaini ◽  
Simone Sulpizio
Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 689
Author(s):  
Giulia Menculini ◽  
Pierfrancesco Maria Balducci ◽  
Luigi Attademo ◽  
Francesco Bernardini ◽  
Patrizia Moretti ◽  
...  

Background and objectives: A deeper comprehension of the role that environmental risk factors play in the development of adolescent Bipolar Disorder (BD), as well as in the evolution of high-risk states for BD, may entangle further prevention and treatment advances. The present systematic review is aimed at critically summarizing evidence about the role that environmental risk factors play in the development of BD in adolescence and their interaction with BD high-risk states. Materials and Methods: MEDLINE/Pubmed, Scopus and Web of Science datasets were systematically searched until 4 September 2020. Original studies that reported information about the role of environmental risk factors in the development of BD during adolescence, or assessing their influence on the development of psychopathology in high-risk states for BD, were considered for inclusion. Two blind researchers performed title/abstract, full-text screening, and hand-screening of relevant references. The risk of bias was assessed by means of the Newcastle-Ottawa Scale. Results: Fourteen studies were included in the review. Negative stressful life events, particularly sexual and physical abuse, but also emotional mistreatment, were associated with more severe psychopathology in adolescents with BD, as well as with higher risk for developing mood disorders in BD offspring. Similar findings were detected for familial environment-related features, such as parental rejection and low perceived care, while no univocal results were found when analyzing familial functioning. Conclusions: The present systematic review confirmed the relevant role that environmental risk factors, particularly negative stressful live events and family-related features, play in the development of BD psychopathology during adolescence. Future studies are expected to clarify possible further environmental factors that may be implicated in the development of BD during youth that may serve as target of prevention and early treatment strategies.


BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e023359
Author(s):  
Mohd Hatta Abdul Mutalip ◽  
Mohd Amierul Fikri Mahmud ◽  
Noor Aliza Lodz ◽  
Norzawati Yoep ◽  
Eida Nurhadzira Muhammad ◽  
...  

IntroductionLeptospirosis is the most common zoonotic disease that causes morbidity and mortality worldwide. The disease can cause sporadic epidemics and recent epidemics have become more apparent in urban localities. There is lack of documented evidence on the specific risk factors of leptospirosis infection among the urbanites, thereby impeding initiatives for prevention in urban settings. We aim to systematically search published articles and synthesise evidence on the risk factors associated with leptospirosis infection among the susceptible populations in urban localities, particularly to identify the risk factors of non-recreational leptospirosis infection.Methods and analysisWe will conduct a systematic review of observational studies that investigated environmental risk factors of leptospirosis in urban localities. The search will be performed for any eligible articles from selected electronic databases from 1970 until May 2018. The study will include any studies that investigated risk factors of confirmed leptospirosis cases who acquired the infection in urban locality, particularly exposures from the non-recreational and non-water-related activities. Study selection and reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and Meta-Analysis of Observational Studies in Epidemiology guideline. All data will be extracted using a standardised data extraction form and quality of the studies will be assessed using the Newcastle-Ottawa Scale guideline. Descriptive and meta-analysis will be performed by calculating the standardised median ORs and risk ratios for types of the non-recreational risk factors stratified by social, living conditions and environmental exposures, types of reservoirs and transmissions and types of activities and employments associated with leptospirosis infection in urban locality.Ethics and disseminationNo primary data will be collected thus no formal ethical approval is required. The results will be disseminated though a peer-reviewed publication and conference presentation.PROSPERO registration numberCRD42018090820.


2015 ◽  
Vol 5 (11) ◽  
pp. 996-1003 ◽  
Author(s):  
Agnes S. Sundaresan ◽  
Annemarie G. Hirsch ◽  
Margaret Storm ◽  
Bruce K. Tan ◽  
Thomas L. Kennedy ◽  
...  

2019 ◽  
Vol 22 (4) ◽  
pp. 502-526 ◽  
Author(s):  
Andreia Azeredo ◽  
Diana Moreira ◽  
Patrícia Figueiredo ◽  
Fernando Barbosa

2017 ◽  
Vol 42 (7-8) ◽  
pp. 423-445 ◽  
Author(s):  
Natalia Becker ◽  
Mailton Vasconcelos ◽  
Vanessa Oliveira ◽  
Fernanda Caroline Dos Santos ◽  
Lisiane Bizarro ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yeonkyung Park ◽  
Chiwon Ahn ◽  
Tae-Hyung Kim

AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease of unknown cause. It has a high risk of rapid progression and mortality. We conducted a systematic review and meta-analysis to evaluate the risk factor of IPF. We searched Medline, Embase, and the Cochrane library from the earliest record to March, 2020. Case–control studies on occupational and environmental risk factors or on jobs with a risk of IPF were searched for. From 2490 relevant records, 12 studies were included. Any occupational or environmental exposure to metal dust (OR 1.83, 95% CI 1.15–2.91, I2 = 54%), wood dust (OR 1.62 5% CI 1.04–2.53, I2 = 5%) and pesticide (OR 2.07, 95% CI 1.24–3.45, I2 = 0%) were associated with an increased risk of IPF. Farming or agricultural work (OR 1.88, 95% CI 1.17–3.04, I2 = 67%) was also associated with an increased risk of IPF. Moreover, smoking increased IPF risk with an odds ratio of 1.39 (95% CI 1.01–1.91, I2 = 29%). In conclusion, metal dust, wood dust, pesticide, occupational history of farming or agriculture and ever smoking increased the risk of IPF.


2021 ◽  
pp. 105566562110189
Author(s):  
Kayla Kruppa ◽  
Esedra Krüger ◽  
Carlien Vorster ◽  
Jeannie van der Linde

Objective: To identify and review published data on the risks associated with cleft lip and/or palate (CL/P) in lower-middle-income countries (LMICs). Design: A systematic review of literature was performed on electronic databases using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. Literature on risks associated with CL/P in LMICs, from 2010 to 2020, were included. Results: Seventeen studies met the inclusion criteria. All studies adopted an observational study design. Biological and environmental risks were identified. Maternal and paternal age (n = 7) and low socioeconomic status (n = 5) were the most prominently associated environmental risk factors. A strong association was identified between family history of cleft (n = 7) and CL/P occurrence. Conclusion: Environmental risk factors are now being investigated more than biological risk factors in LMICs, aiding health care workers in the early identification of possible cumulative effects of risks in CL/P. Contextually relevant tools are recommended to promote early identification of at-risk infants.


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