scholarly journals A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers

2016 ◽  
Vol 22 (18) ◽  
pp. 4698-4711 ◽  
Author(s):  
Georg Karpel-Massler ◽  
Basil A. Horst ◽  
Chang Shu ◽  
Lily Chau ◽  
Takashi Tsujiuchi ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Broad Spectrum ◽  
Dominant Negative ◽  
Treatment Resistant ◽  
Synthetic Cell ◽  
Cell Penetrating

scholarly journals Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

2021 ◽  
Author(s):  
Rocío Recio ◽  
Patricia Lerena ◽  
Esther Pozo ◽  
José Manuel Calderón-Montaño ◽  
Estefanía Burgos-Morón ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Broad Spectrum

Levofloxacin exerts broad-spectrum anticancer activity via regulation of THBS1, LAPTM5, SRD5A3, MFAP5 and P4HA1

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Xiaoqiong He ◽  
Qian Yao ◽  
Duane D Hall ◽  
Zhongyu Song ◽  
Dan Fan ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Broad Spectrum

scholarly journals A Synthetic Cell-Penetrating Heparin-Binding Peptide Derived from BMP4 with Anti-Inflammatory and Chondrogenic Functions for the Treatment of Arthritis

2020 ◽  
Vol 21 (12) ◽  
pp. 4251
Author(s):  
Da Hyeon Choi ◽  
Dongwoo Lee ◽  
Beom Soo Jo ◽  
Kwang-Sook Park ◽  
Kyeong Eun Lee ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Combined Treatment ◽  
Therapeutic Effects ◽  
Heparin Binding ◽  
Rheumatic Arthritis ◽  
Binding Peptide ◽  
Human Knee ◽  
Synthetic Cell ◽  
Cell Penetrating ◽  
Anti Inflammatory

We report dual therapeutic effects of a synthetic heparin-binding peptide (HBP) corresponding to residues 15–24 of the heparin binding site in BMP4 in a collagen-induced rheumatic arthritis model (CIA) for the first time. The cell penetrating capacity of HBP led to improved cartilage recovery and anti-inflammatory effects via down-regulation of the iNOS-IFNγ-IL6 signaling pathway in inflamed RAW264.7 cells. Both arthritis and paw swelling scores were significantly improved following HBP injection into CIA model mice. Anti-rheumatic effects were accelerated upon combined treatment with Enbrel® and HBP. Serum IFNγ and IL6 concentrations were markedly reduced following intraperitoneal HBP injection in CIA mice. The anti-rheumatic effects of HBP in mice were similar to those of Enbrel®. Furthermore, the combination of Enbrel® and HBP induced similar anti-rheumatic and anti-inflammatory effects as Enbrel®. We further investigated the effect of HBP on damaged chondrocytes in CIA mice. Regenerative capacity of HBP was confirmed based on increased expression of chondrocyte biomarker genes, including aggrecan, collagen type II and TNFα, in adult human knee chondrocytes. These findings collectively support the utility of our cell-permeable bifunctional HBP with anti-inflammatory and chondrogenic properties as a potential source of therapeutic agents for degenerative inflammatory diseases.

scholarly journals A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice

2010 ◽  
Vol 114 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Wei-Ying Ma ◽  
Eri Murata ◽  
Koyo Ueda ◽  
Yoshihiro Kuroda ◽  
Ming-Hui Cao ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cell Penetrating Peptide ◽  
Synthetic Cell ◽  
Cell Penetrating

Evaluation of Synthetic Cell-Penetrating Peptides, Pro-Rich Peptide and Octaargine Derivatives, as Adenovirus Vector Carrier

2010 ◽  
Vol 17 (2) ◽  
pp. 164-167 ◽  
Author(s):  
Shinya Kida ◽  
Yusuke Eto ◽  
Yasuo Yoshioka ◽  
Shinsaku Nakagawa ◽  
Koichi Kawasaki ◽  
...  
Keyword(s):  
Adenovirus Vector ◽  
Cell Penetrating Peptides ◽  
Synthetic Cell ◽  
Cell Penetrating
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