scholarly journals A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy

2020 ◽  
Author(s):  
Brian H. Santich ◽  
Sarah M. Cheal ◽  
Mahiuddin Ahmed ◽  
Michael R. McDevitt ◽  
Ouathek Ouerfelli ◽  
...  
Keyword(s):  
Bispecific Antibody ◽  
Self Assembling ◽  
Pretargeted Radioimmunotherapy

scholarly journals CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies

Blood ◽  
2018 ◽  
Vol 131 (6) ◽  
pp. 611-620 ◽  
Author(s):  
Damian J. Green ◽  
Shyril O’Steen ◽  
Yukang Lin ◽  
Melissa L. Comstock ◽  
Aimee L. Kenoyer ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
B Cell ◽  
Bispecific Antibody ◽  
Murine Models ◽  
B Cell Malignancies ◽  
Key Points ◽  
Pretargeted Radioimmunotherapy

Key Points A novel bispecific antibody against CD38 eradicates MM and NHL tumors in murine models. CD38-bispecific antibody pretargeting addresses limitations associated with radioimmunotherapy.

scholarly journals Therapeutic Advantage of Pretargeted Radioimmunotherapy Using a Recombinant Bispecific Antibody in a Human Colon Cancer Xenograft

2005 ◽  
Vol 11 (21) ◽  
pp. 7879-7885 ◽  
Author(s):  
Habibe Karacay ◽  
Pierre-Yves Brard ◽  
Robert M. Sharkey ◽  
Chien-Hsing Chang ◽  
Edmund A. Rossi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Bispecific Antibody ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Therapeutic Advantage ◽  
Pretargeted Radioimmunotherapy

scholarly journals Pretargeted Radioimmunotherapy of Prostate Cancer with an Anti-TROP-2×Anti-HSG Bispecific Antibody and a 177Lu-Labeled Peptide

2014 ◽  
Vol 29 (8) ◽  
pp. 323-329 ◽  
Author(s):  
Catharina M. van Rij ◽  
Cathelijne Frielink ◽  
David M. Goldenberg ◽  
Robert M. Sharkey ◽  
Susanne Lütje ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bispecific Antibody ◽  
Pretargeted Radioimmunotherapy

Torus Circumference and Thickness Parameters From a Linear DNA Size Series Suggest How Toruses Self-Assemble

1985 ◽  
Vol 43 ◽  
pp. 522-523
Author(s):  
George C. Ruben ◽  
Kenneth A. Marx
Keyword(s):  
Tertiary Structure ◽  
Dna Complexes ◽  
Tertiary Structures ◽  
Self Assembling ◽  
Double Stranded Dna ◽  
Calf Thymus ◽  
Dna Organization ◽  
Condensed Dna ◽  
Dna Size

Certain double stranded DNA bacteriophage and viruses are thought to have their DNA organized into large torus shaped structures. Morphologically, these poorly understood biological DNA tertiary structures resemble spermidine-condensed DNA complexes formed in vitro in the total absence of other macromolecules normally synthesized by the pathogens for the purpose of their own DNA packaging. Therefore, we have studied the tertiary structure of these self-assembling torus shaped spermidine- DNA complexes in a series of reports. Using freeze-etch, low Pt-C metal (10-15Å) replicas, we have visualized the microscopic DNA organization of both calf Thymus( CT) and linear 0X-174 RFII DNA toruses. In these structures DNA is circumferentially wound, continuously, around the torus into a semi-crystalline, hexagonal packed array of parallel DNA helix sections.

Structure–property studies of self-assembling [n.n]paracyclophanes

2020 ◽  
Author(s):  
Will R Henderson ◽  
Danielle E. Fagnani ◽  
Yu Zhu ◽  
Guancen Liu ◽  
Ronald K. Castellano
Keyword(s):  
Structure Property ◽  
Self Assembling
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