scholarly journals Small interfering RNA targeting of S phase kinase–interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation

2005 ◽  
Vol 4 (3) ◽  
pp. 471-476
Author(s):  
Yasusei Kudo ◽  
Shojiro Kitajima ◽  
Ikuko Ogawa ◽  
Masae Kitagawa ◽  
Mutsumi Miyauchi ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Small Interfering Rna ◽  
S Phase ◽  
Interacting Protein ◽  
Rna Targeting ◽  
Oral Cancer Cells ◽  
Interfering Rna

scholarly journals Soft Coral-Derived Dihydrosinularin Exhibits Antiproliferative Effects Associated with Apoptosis and DNA Damage in Oral Cancer Cells

2021 ◽  
Vol 14 (10) ◽  
pp. 994
Author(s):  
Kun-Han Yang ◽  
Yu-Sheng Lin ◽  
Sheng-Chieh Wang ◽  
Min-Yu Lee ◽  
Jen-Yang Tang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cell Growth ◽  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Soft Coral ◽  
Oral Cancer Cells

Dihydrosinularin (DHS) is an analog of soft coral-derived sinularin; however, the anticancer effects and mechanisms of DHS have seldom been reported. This investigation examined the antiproliferation ability and mechanisms of DHS on oral cancer cells. In a cell viability assay, DHS showed growth inhibition against several types of oral cancer cell lines (Ca9-22, SCC-9, OECM-1, CAL 27, OC-2, and HSC-3) with no cytotoxic side effects on non-malignant oral cells (HGF-1). Ca9-22 and SCC-9 cell lines showing high susceptibility to DHS were selected to explore the antiproliferation mechanisms of DHS. DHS also causes apoptosis as detected by annexin V, pancaspase, and caspase 3 activation. DHS induces oxidative stress, leading to the generation of reactive oxygen species (ROS)/mitochondrial superoxide (MitoSOX) and mitochondrial membrane potential (MitoMP) depletion. DHS also induced DNA damage by probing γH2AX phosphorylation. Pretreatment with the ROS scavenger N-acetylcysteine (NAC) can partly counter these DHS-induced changes. We report that the marine natural product DHS can inhibit the cell growth of oral cancer cells. Exploring the mechanisms of this cancer cell growth inhibition, we demonstrate the prominent role DHS plays in oxidative stress.

scholarly journals Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Cheng-Yu Yang ◽  
Cheng-Chih Hsieh ◽  
Chih-Kung Lin ◽  
Chun-Shu Lin ◽  
Bo Peng ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cell Growth ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Oral Cancer Cells

Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells

2009 ◽  
Vol 280 (1) ◽  
pp. 110-119 ◽  
Author(s):  
Haiyan You ◽  
Jie Jin ◽  
Huiqun Shu ◽  
Bin Yu ◽  
Angelo De Milito ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Proton Pump ◽  
Small Interfering Rna ◽  
Breast Cancer Cells ◽  
Rna Targeting ◽  
Interfering Rna

Down-regulation of S-phase kinase associated protein 2 (Skp2) induces apoptosis in oral cancer cells

Oral Oncology ◽  
2005 ◽  
Vol 41 (6) ◽  
pp. 623-630 ◽  
Author(s):  
Koji Harada ◽  
Supriatno ◽  
Yuichiro Kawashima ◽  
Yasutaka Itashiki ◽  
Hideo Yoshida ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
S Phase ◽  
Down Regulation ◽  
Oral Cancer Cells
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