Photodynamic Therapy Using Indocyanine Green Loaded on Super Carbonate Apatite as Minimally Invasive Cancer Treatment

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in vacuo, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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A new NIR-triggered doxorubicin and photosensitizer indocyanine green co-delivery system for enhanced multidrug resistant cancer treatment through simultaneous chemo/photothermal/photodynamic therapy

Acta Biomaterialia ◽

10.1016/j.actbio.2017.06.026 ◽

2017 ◽

Vol 59 ◽

pp. 170-180 ◽

Cited By ~ 47

Author(s):

Yanna Yu ◽

Zhipeng Zhang ◽

Yun Wang ◽

Hao Zhu ◽

Fangzhou Li ◽

...

Keyword(s):

Photodynamic Therapy ◽

Indocyanine Green ◽

Cancer Treatment ◽

Delivery System ◽

Multidrug Resistant

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An efficient delivery of photosensitizers and hypoxic prodrugs for a tumor combination therapy by membrane camouflage nanoparticles

Journal of Materials Chemistry B ◽

10.1039/d0tb00235f ◽

2020 ◽

Vol 8 (14) ◽

pp. 2876-2886 ◽

Cited By ~ 3

Author(s):

Hanjie Wang ◽

Chaonan Zhang ◽

Yingying Zhang ◽

Ran Tian ◽

Guohui Cheng ◽

...

Keyword(s):

Photodynamic Therapy ◽

Combination Therapy ◽

Cancer Treatment ◽

Invasive Cancer ◽

Non Invasive ◽

Efficient Delivery

Photodynamic therapy (PDT) is an oxygen-dependent, non-invasive cancer treatment.

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Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

10.26434/chemrxiv.12118917.v1 ◽

2020 ◽

Author(s):

busenur Aslanoglu ◽

Ilya Yakavets ◽

Vladimir Zorin ◽

Henri-Pierre Lassalle ◽

Francesca Ingrosso ◽

...

Keyword(s):

Drug Delivery ◽

Optical Properties ◽

Photodynamic Therapy ◽

Minimally Invasive ◽

Visible Light ◽

Cancer Treatment ◽

Singlet Oxygen ◽

Tumor Cells ◽

Molecular Oxygen ◽

Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in vacuo, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics

Photochemical & Photobiological Sciences ◽

10.1039/c5pp00027k ◽

2015 ◽

Vol 14 (8) ◽

pp. 1433-1450 ◽

Cited By ~ 20

Author(s):

Pål Kristian Selbo ◽

Monica Bostad ◽

Cathrine Elisabeth Olsen ◽

Victoria Tudor Edwards ◽

Anders Høgset ◽

...

Keyword(s):

Stem Cell ◽

Photodynamic Therapy ◽

Minimally Invasive ◽

Cancer Stem Cell ◽

Cancer Treatment ◽

Treatment Resistance ◽

Endosomal Escape ◽

Cell Targeting ◽

Invasive Strategy

Despite progress in radio-, chemo- and photodynamic-therapy (PDT) of cancer, treatment resistance still remains a major problem for patients with aggressive tumours.

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Optical properties of photodynamic therapy drugs in different environments: the paradigmatic case of temoporfin

Physical Chemistry Chemical Physics ◽

10.1039/d0cp02055a ◽

2020 ◽

Vol 22 (29) ◽

pp. 16956-16964

Author(s):

Busenur Aslanoglu ◽

Ilya Yakavets ◽

Vladimir Zorin ◽

Henri-Pierre Lassalle ◽

Francesca Ingrosso ◽

...

Keyword(s):

Optical Properties ◽

Photodynamic Therapy ◽

Minimally Invasive ◽

Cancer Treatment ◽

Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) – a minimally invasive, less aggressive alternative for cancer treatment.

Download Full-text

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

10.26434/chemrxiv.12118917 ◽

2020 ◽

Author(s):

busenur Aslanoglu ◽

Ilya Yakavets ◽

Vladimir Zorin ◽

Henri-Pierre Lassalle ◽

Francesca Ingrosso ◽

...

Keyword(s):

Drug Delivery ◽

Optical Properties ◽

Photodynamic Therapy ◽

Minimally Invasive ◽

Visible Light ◽

Cancer Treatment ◽

Singlet Oxygen ◽

Tumor Cells ◽

Molecular Oxygen ◽

Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in vacuo, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Download Full-text