Abstract 5365: Zeranol-containing serum (Z-Sera) harvested from 30-day Z-implanted heifers induce transformation of human normal breast epithelial cells through down-regulation of the protein tyrosine phosphatase γ (PTPγ) tumor suppressor gene

2010 ◽  
Author(s):  
Young C. Lin ◽  
Weiping Ye ◽  
Ping-Ping Xu ◽  
Walter R. Threlfall ◽  
Hong Li ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Epithelial Cells ◽  
Tumor Suppressor Gene ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Suppressor Gene ◽  
Normal Breast ◽  
Down Regulation ◽  
Breast Epithelial Cells ◽  
Normal Breast Epithelial Cells

scholarly journals The Role of the Tumor Suppressor Gene Protein Tyrosine Phosphatase Gamma in Cancer

2022 ◽  
Vol 9 ◽  
Author(s):  
Christian Boni ◽  
Claudio Sorio
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Protein Tyrosine Phosphatase ◽  
Growth Regulation ◽  
Current Knowledge ◽  
Tyrosine Phosphatase ◽  
Suppressor Gene ◽  
Missense Mutations ◽  
Protein Tyrosine

Members of the Protein Tyrosine Phosphatase (PTPs) family are associated with growth regulation and cancer development. Acting as natural counterpart of tyrosine kinases (TKs), mainly involved in crucial signaling pathways such as regulation of cell cycle, proliferation, invasion and angiogenesis, they represent key parts of complex physiological homeostatic mechanisms. Protein tyrosine phosphatase gamma (PTPRG) is classified as a R5 of the receptor type (RPTPs) subfamily and is broadly expressed in various isoforms in different tissues. PTPRG is considered a tumor-suppressor gene (TSG) mapped on chromosome 3p14-21, a region frequently subject to loss of heterozygosity in various tumors. However, reported mechanisms of PTPRG downregulation include missense mutations, ncRNA gene regulation and epigenetic silencing by hypermethylation of CpG sites on promoter region causing loss of function of the gene product. Inactive forms or total loss of PTPRG protein have been described in sporadic and Lynch syndrome colorectal cancer, nasopharyngeal carcinoma, ovarian, breast, and lung cancers, gastric cancer or diseases affecting the hematopoietic compartment as Lymphoma and Leukemia. Noteworthy, in Central Nervous System (CNS) PTPRZ/PTPRG appears to be crucial in maintaining glioblastoma cell-related neuronal stemness, carving out a pathological functional role also in this tissue. In this review, we will summarize the current knowledge on the role of PTPRG in various human cancers.

Protein Tyrosine Phosphatase Receptor Type γ Is a Functional Tumor Suppressor Gene Specifically Downregulated in Chronic Myeloid Leukemia

2010 ◽  
Vol 70 (21) ◽  
pp. 8896-8906 ◽  
Author(s):  
Marco Della Peruta ◽  
Giovanni Martinelli ◽  
Elisabetta Moratti ◽  
Davide Pintani ◽  
Marzia Vezzalini ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Protein Tyrosine Phosphatase ◽  
Myeloid Leukemia ◽  
Tyrosine Phosphatase ◽  
Suppressor Gene ◽  
Receptor Type ◽  
Protein Tyrosine

scholarly journals Expression of estrogen receptor β isoforms in normal breast epithelial cells and breast cancer: regulation by methylation

Oncogene ◽  
2003 ◽  
Vol 22 (48) ◽  
pp. 7600-7606 ◽  
Author(s):  
Chunyan Zhao ◽  
Eric W-F Lam ◽  
Andrew Sunters ◽  
Eva Enmark ◽  
Manuela Tamburo De Bella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Epithelial Cells ◽  
Normal Breast ◽  
Estrogen Receptor Β ◽  
Breast Epithelial Cells ◽  
Breast Epithelial ◽  
Normal Breast Epithelial Cells

Down regulation of the tumor suppressor gene maspin in breast carcinoma is associated with a higher risk of distant metastasis

2001 ◽  
Vol 34 (4) ◽  
pp. 303-307 ◽  
Author(s):  
Nicolai Maass ◽  
Takashi Hojo ◽  
Frank Rösel ◽  
Tadashi Ikeda ◽  
Walter Jonat ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Distant Metastasis ◽  
Suppressor Gene ◽  
Down Regulation

URINARY BLADDER TRANSITIONAL CELL CARCINOGENESIS IS ASSOCIATED WITH DOWN-REGULATION OF NF1 TUMOR SUPPRESSOR GENE IN VIVO AND IN VITRO

1999 ◽  
pp. 117
Author(s):  
Vesa A. Aaltonen ◽  
Peter J. Bostrom ◽  
Karl-Ove Soderstrom ◽  
Outi Hirvonen ◽  
Juha Tuukkanen ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Urinary Bladder ◽  
Tumor Suppressor Gene ◽  
Transitional Cell ◽  
Suppressor Gene ◽  
Down Regulation

scholarly journals Urinary Bladder Transitional Cell Carcinogenesis Is Associated with Down-Regulation of NF1 Tumor Suppressor Gene in Vivo and in Vitro

1999 ◽  
Vol 154 (3) ◽  
pp. 755-765 ◽  
Author(s):  
Vesa Aaltonen ◽  
Peter J. Boström ◽  
Karl-Ove Söderström ◽  
Outi Hirvonen ◽  
Juha Tuukkanen ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Urinary Bladder ◽  
Tumor Suppressor Gene ◽  
Transitional Cell ◽  
Suppressor Gene ◽  
Down Regulation
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