Abstract 1908: Meta-analysis of prospective epidemiologic studies of red meat intake and colorectal cancer

2011 ◽  
Author(s):  
Dominik D. Alexander ◽  
Colleen A. Cushing ◽  
Vanessa Perez ◽  
Douglas L. Weed
Keyword(s):  
Colorectal Cancer ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Red Meat ◽  
Meat Intake ◽  
Red Meat Intake

scholarly journals Red Meat Intake and Risk of Rheumatoid Arthritis: A Categorical and Dose-Response Meta-Analysis

2021 ◽  
Author(s):  
WeiWei Chen ◽  
Ke Liu ◽  
Qing Su ◽  
Xinxian Sang ◽  
Yihan Hu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Red Meat ◽  
High Dose ◽  
Case Control Studies ◽  
Meat Intake ◽  
Red Meat Intake ◽  
The Impact

Abstract Objective: Findings from previous observational studies on the association between red meat intake and risk of rheumatoid arthritis (RA) are inconsistent. Therefore, we aimed to evaluate the impact of red meat intake on the incidence of RA by meta-analysis.Methods: PubMed and Web of Science were searched for eligible observational studies regarding the association between red meat intake and the risk of RA until June 30, 2021. Risk estimates with corresponding 95% confidence interval (95% CI) were pooled. Subgroup analysis and meta-regression analysis were performed to explore the potential sources of heterogeneity. Sensitivity analysis and publication bias test were also carried out.Results: A total of eleven studies were selected, involving 4 cohort studies with 5 203 identified cases from 349 776 individuals and 7 case-control studies with 3 762 cases and 6 856 controls. The pooled risk estimate of RA risk was 0.94 (95% CI: 0.77 to 1.15) for ever versus non/occasional red meat intake, while high dose of red meat intake increased the risk of RA (OR: 1.26, 95% CI: 1.07 to 1.50) in the categorical meta-analysis. Dose-response meta-analysis suggested a non-linear dose-response relationship between red meat intake and RA (P=0.028). Red meat intake was found to be a risk factor of RA when the dose ranged from 96 to 166 g/day.Conclusion: High dose of red meat intake could increase the risk of RA. Mechanistic studies are warranted to clarify the aetiologic pathways through which high dose of red meat intake may promote RA.

scholarly journals Red Meat Intake and Risk of Non-Hodgkin Lymphoma: A Meta-Analysis

2015 ◽  
Vol 15 (23) ◽  
pp. 10421-10425 ◽  
Author(s):  
Hosein Fallahzadeh ◽  
Maria Cheraghi ◽  
Neda Amoori ◽  
Mehrangiz Alaf
Keyword(s):  
Hodgkin Lymphoma ◽  
Meta Analysis ◽  
Red Meat ◽  
Meat Intake ◽  
Non Hodgkin Lymphoma ◽  
Red Meat Intake

scholarly journals Red Meat Intake, NAT2, and Risk of Colorectal Cancer: A Pooled Analysis of 11 Studies

2014 ◽  
Vol 24 (1) ◽  
pp. 198-205 ◽  
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Mengmeng Du ◽  
Sonja I. Berndt ◽  
Hermann Brenner ◽  
Bette J. Caan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Pooled Analysis ◽  
Red Meat ◽  
Meat Intake ◽  
Red Meat Intake

scholarly journals The Influence of Red Meat on Colorectal Cancer Occurrence Is Dependent on the Genetic Polymorphisms of S-Glutathione Transferase Genes

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1682 ◽  
Author(s):  
Justyna Klusek ◽  
Anna Nasierowska-Guttmejer ◽  
Artur Kowalik ◽  
Iwona Wawrzycka ◽  
Magdalena Chrapek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gene Polymorphism ◽  
High Frequency ◽  
Glutathione Transferase ◽  
Fold Increase ◽  
Meat Consumption ◽  
Red Meat ◽  
Meat Intake ◽  
Gstm1 Gene ◽  
Red Meat Intake

Background: It is postulated that both individual genotype and environmental factors such as diet may modify the risk of developing colorectal cancer (CRC). The influences of GST gene polymorphism and red meat intake on CRC occurrence in the Polish population were analyzed in this study. Methods: Genotyping was performed with the qPCR method. Results: A high frequency of meat consumption was associated with an over 2-fold increase in the risk of colorectal cancer odds ratio (OR) adjusted for sex and age = 2.4, 95% confidence interval (CI); 1.3–4.4). However, after analyzing the genetic profiles, in the absence of polymorphisms of all three analyzed genes, there was no association between a high frequency of meat consumption and the occurrence of CRC. In the case of GSTM1 gene polymorphism, the high frequency of meat consumption increased the risk of CRC by almost more than 4 times (OR adjusted for sex and age = 3.8, 95% CI: 1.6–9.1). For GSTP1 gene polymorphism, a 3-fold increase in CRC risk was observed with a high frequency of meat consumption (OR adjusted for sex and age = 3.4, 95% CI: 1.4–8.1). In the case of GSTT1 gene polymorphism, the increase in risk of CRC was not statistically significant (OR adjusted for sex and age = 1.9, 95% CI: 0.4–8.5). Conclusions: The frequency of red meat intake in non-smokers increases the risk of colon cancer in the case of GST gene polymorphisms.

scholarly journals Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-Metabolizing Enzymes, and Colorectal Cancer Risk

2008 ◽  
Vol 17 (11) ◽  
pp. 3098-3107 ◽  
Author(s):  
Michelle Cotterchio ◽  
Beatrice A. Boucher ◽  
Michael Manno ◽  
Steven Gallinger ◽  
Allan B. Okey ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Red Meat ◽  
Colorectal Cancer Risk ◽  
Metabolizing Enzymes ◽  
Meat Intake ◽  
Red Meat Intake

scholarly journals Red meat intake as a suspicious factor of colorectal cancer at Sanglah General Hospital in 2017

2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Ganeshwary Nishal Ganasan ◽  
Made Agus Dwianthara Sueta ◽  
Made Suka Adnyana
Keyword(s):  
Colorectal Cancer ◽  
General Hospital ◽  
Red Meat ◽  
Meat Intake ◽  
Red Meat Intake

Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk

2019 ◽  
Vol 28 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Na-Hui Kim ◽  
Ju Eun Seol ◽  
Jeongseon Kim ◽  
Bong-Hwa Lee ◽  
Dae-Yong Hwang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Red Meat ◽  
Colorectal Cancer Risk ◽  
Meat Intake ◽  
Red Meat Intake

scholarly journals Red Meat Intake and Glycemic and Insulinemic Risk Factors for Type 2 Diabetes: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 522-522
Author(s):  
Lisa Sanders ◽  
Meredith Wilcox ◽  
Kevin Maki
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Glucose Tolerance ◽  
Fasting Glucose ◽  
Meta Analysis ◽  
Postprandial Glucose ◽  
Red Meat ◽  
Meat Intake ◽  
Red Meat Intake

Abstract Objectives Results from observational studies have suggested an association of red meat intake with increased risk of type 2 diabetes (T2D).  However, results from randomized controlled trials (RCTs) have not shown clear evidence to support a mechanistic link between red meat intake and T2D risk factors.  The objective of this systematic review and meta-analysis was to evaluate the impact of red meat intake on markers of glucose tolerance, including fasting glucose and insulin, postprandial glucose and insulin, insulin sensitivity and glycated hemoglobin (HbA1c). Methods A systematic review and meta-analysis was conducted on RCTs evaluating the effect of red meat intake, compared to lower or no red meat intake, on markers of glucose tolerance in adults.  A search of PubMed yielded 17 relevant RCTs.  Pooled estimates were expressed as standardized mean differences (SMD) between the red meat intervention and the control intervention with less or no red meat. Results Compared to diets with little or no red meat intake, there was no significant impact of red meat intake on insulin sensitivity (SMD: −0.12; 95% CI: −0.43, 0.19), insulin resistance (SMD: 0.23; 95% CI: −0.22, 0.68), fasting glucose (SMD: 0.12; 95% CI: −0.06, 0.30), fasting insulin (SMD: 0.16; 95% CI: −0.10, 0.42) or HbA1c (SMD: 0.00; 95% CI: −0.42, 0.43).  Red meat intake modestly, but significantly, reduced postprandial glucose (SMD: −0.46; 95% CI: −0.77, −0.16; P < 0.003) compared to diets with little or no red meat intake in a small number of studies (n = 3).  However, there was no effect on postprandial insulin (SMD: −0.74; 95% CI: −1.64, 0.16). Conclusions The results of this meta-analysis suggest red meat intake does not impact several glycemic and insulinemic risk factors for T2D.  Thus, it is unclear whether there is a causal relationship with red meat intake and T2D risk or if other confounding lifestyle factors may be driving the observed association.  Further investigations are needed, particularly on other markers of glucose tolerance, such as pancreatic beta-cell function, to better understand whether a causal relationship exists between red meat intake and risk of T2D.  PROSPERO Registration:   CRD42020176059 Funding Sources This research was funded by Beef Checkoff.

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