Abstract LB-161: A phase I safety study of NPC-1C, a novel, therapeutic antibody to treat pancreas and colorectal cancers.

2013 ◽  
Author(s):  
Sandip P. Patel ◽  
Michael A. Morse ◽  
Luiz A. Diaz ◽  
Nilofer S. Azad ◽  
Sherri Haley ◽  
...  
Keyword(s):  
Phase I ◽  
Therapeutic Antibody ◽  
Colorectal Cancers ◽  
Safety Study ◽  
Novel Therapeutic

A phase I study of NPC-1C, a novel therapeutic antibody to treat pancreas and colorectal cancers.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. TPS141-TPS141
Author(s):  
N. S. Azad ◽  
L. A. Diaz ◽  
C. E. Devoe ◽  
D. Laheru ◽  
D. T. Le ◽  
...  
Keyword(s):  
Phase I ◽  
Phase I Study ◽  
Therapeutic Antibody ◽  
Colorectal Cancers ◽  
Novel Therapeutic

Abstract B124: Preclinical development of a novel therapeutic antibody to treat pancreas and colorectal cancers

2009 ◽  
Author(s):  
Philip M. Arlen ◽  
Judith Kantor ◽  
Janos Luka ◽  
Olga Saric ◽  
Rishab Gupta ◽  
...  
Keyword(s):  
Therapeutic Antibody ◽  
Colorectal Cancers ◽  
Preclinical Development ◽  
Novel Therapeutic

scholarly journals A phase I pharmacokinetic and safety study of cabazitaxel in adult cancer patients with normal and impaired renal function

2016 ◽  
Vol 78 (6) ◽  
pp. 1185-1197 ◽  
Author(s):  
Analía Azaro ◽  
Jordi Rodón ◽  
Jean-Pascal Machiels ◽  
Sylvie Rottey ◽  
Silvia Damian ◽  
...  
Keyword(s):  
Renal Function ◽  
Phase I ◽  
Cancer Patients ◽  
Impaired Renal Function ◽  
Safety Study

scholarly journals Biomarker Use in Colorectal Cancer Therapy

2011 ◽  
Vol 9 (11) ◽  
pp. 1293-1302 ◽  
Author(s):  
Robin K. Kelley ◽  
Grace Wang ◽  
Alan P. Venook
Keyword(s):  
Colorectal Cancer ◽  
Clinical Management ◽  
Mutational Analysis ◽  
Colorectal Cancers ◽  
Repair Protein ◽  
Established Role ◽  
Case Based ◽  
Mismatch Repair Protein ◽  
Selection Of ◽  
Novel Therapeutic

Biomarkers reflective of the molecular and genetic heterogeneity in colorectal cancers now guide certain aspects of clinical management and offer great potential for enrichment, stratification, and identification of novel therapeutic targets in drug development. Using case-based examples, this article reviews biomarkers that have an established role in the clinical management of colorectal cancer: mismatch repair protein testing and KRAS and BRAF mutational analysis. A selection of biomarkers undergoing validation for future clinical application is presented, and the dynamic and challenging interface between biomarkers in research and clinical practice is discussed.

TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo

2018 ◽  
Vol 18 (3) ◽  
pp. 632-641 ◽  
Author(s):  
Srimoyee Ghosh ◽  
Geeta Sharma ◽  
Jon Travers ◽  
Sujatha Kumar ◽  
Justin Choi ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Therapeutic Antibody ◽  
T Cell Function ◽  
Antibody Targeting ◽  
Novel Therapeutic

A phase I randomized safety study of a single-size silicone rubber diaphragm used with or without a lactic-acid-containing diaphragm gel

Contraception ◽  
2019 ◽  
Vol 100 (6) ◽  
pp. 430-437 ◽  
Author(s):  
Andrea Thurman ◽  
Tina Cunningham ◽  
Raina Fichorova ◽  
Betsy C. Herold ◽  
Sharon L. Hillier ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Phase I ◽  
Silicone Rubber ◽  
Safety Study ◽  
Single Size

Intralesional allogeneic adipose-derived stem cells application in chronic diabetic foot ulcer: Phase I/2 safety study

2020 ◽  
Author(s):  
Erdal Uzun ◽  
Ahmet Güney ◽  
Zeynep Burçin Gönen ◽  
Yusuf Özkul ◽  
İbrahim Halil Kafadar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Phase I ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Adipose Derived Stem Cells ◽  
Safety Study

scholarly journals Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS – A Novel Therapeutic Opportunity

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132011 ◽  
Author(s):  
Lena Winstedt ◽  
Sofia Järnum ◽  
Emma Andersson Nordahl ◽  
Andreas Olsson ◽  
Anna Runström ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Phase I Study ◽  
Complete Removal ◽  
Igg Antibodies ◽  
Bacterial Enzyme ◽  
Therapeutic Opportunity ◽  
Novel Therapeutic

P.6.c.003 Aripirazole for methamphetamine dependence; a phase I human safety study

2007 ◽  
Vol 17 ◽  
pp. S550-S551
Author(s):  
A. Elkashef ◽  
T. Newton ◽  
R. De la Garza ◽  
M. Reid ◽  
J. Mojsiak
Keyword(s):  
Phase I ◽  
Safety Study ◽  
Human Safety ◽  
Methamphetamine Dependence
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