Abstract 2803: Oral administration of an acid stable liposomal formulation of docosahexaenoic acid (DHA) delivers DHA and its LOX-metabolites to the circulation and the breast tissue of sprague dawley rats

2015 ◽  
Author(s):  
Christine G. Skibinski ◽  
Arunangshu Das ◽  
Kun-Ming Chen ◽  
Neil Trushin ◽  
Bogdan Prokopczyk ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Oral Administration ◽  
Breast Tissue ◽  
Liposomal Formulation ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Acid Stable

Serum metabolomic signatures of Sprague-Dawley rats after oral administration of titanium dioxide nanoparticles

NanoImpact ◽  
2020 ◽  
Vol 19 ◽  
pp. 100236
Author(s):  
Zhangjian Chen ◽  
Shuo Han ◽  
Di Zhou ◽  
Pai Zheng ◽  
Shupei Zhou ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Oral Administration ◽  
Titanium Dioxide Nanoparticles ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application

Xenobiotica ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 169-181 ◽  
Author(s):  
James M. Mathews ◽  
Sherri S. Brown ◽  
Purvi R. Patel ◽  
Sherry R. Black ◽  
Troy T. Banks ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats ◽  
Dermal Application

scholarly journals Absorption, Distribution, Excretion, and Pharmacokinetics ofC-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Sang Hyun Park ◽  
Kannampalli Pradeep
Keyword(s):  
Clinical Trials ◽  
Small Intestine ◽  
Oral Administration ◽  
Female Rats ◽  
Sprague Dawley ◽  
Male And Female ◽  
Phase Ii Clinical Trials ◽  
Male And Female Rats ◽  
Sprague Dawley Rats ◽  
Peak Value

The main objective of this investigation was to determine the absorption, distribution, excretion, and pharmacokinetics of the antimalarial drug pyronaridine tetraphosphate (PNDP) in Sprague-Dawley rats. Following oral administration of a single dose (10 mg/Kg) ofC-PNDP, it was observed that the drug was readily absorbed from the small intestine within 1 hour following oral administration and was widely distributed in most of the tissues investigated as determined from the observed radioactivity in the tissues. The peak value of the drug in the blood was reached at around 8 hours postadministration, and radioactivity was detected in most of the tissues from 4 hours onwards.C-PNDP showed a poor permeability across the blood-brain barrier, and the absorption, distribution, and excretion ofC-PNDP were found to be gender-independent as both male and female rats showed a similar pattern of radioactivity. Excretion of the drug was predominantly through the urine with a peak excretion post 24 hours of administration. A small amount of the drug was also excreted in the feces and also in the breath. It was found that theCmax, AUC (0-inf), andTmaxvalues were similar to those observed in the Phase II clinical trials of pyronaridine/artesunate (Pyramax) conducted in Uganda.

scholarly journals Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4375
Author(s):  
Hyesook Lee ◽  
Hyun Hwangbo ◽  
Seon Yeong Ji ◽  
Min Yeong Kim ◽  
So Young Kim ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Oral Administration ◽  
Growth Plate ◽  
Bone Health ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Tibial Growth Plate ◽  
Igfbp 3

Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulation and the proximal tibial growth plate. Therefore, in this study, we investigated the effect of FO oral administration on hepatic and serum growth regulator levels and the development of the proximal tibial growth plate in young Sprague-Dawley rats. Both oral administration of FO (FO 100, 100 mg/kg FO and FO 200, 200 mg/kg FO) and subcutaneous injection of recombinant human growth hormone (rhGH, 200 μg/kg of rhGH) for two weeks showed no toxicity. Circulating levels of growth hormone (GH) significantly increased in the FO 200 group. The expression and secretion of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were enhanced by FO administration. FO administration promoted the expression of bone morphogenic proteins IGF-1 and IGFBP-3 in the proximal tibial growth plate. This positive effect of FO resulted in incremental growth of the entire plate length by expanding the proliferating and hypertrophic zones in the proximal tibial growth plate. Collectively, our results suggested that oral administration of FO is beneficial for bone health, which may ultimately result in increased height.

Oral administration of paclitaxel affects the distribution and metabolism of 2-aminofluorene in various tissues of Sprague-Dawley rats

Phytomedicine ◽  
2005 ◽  
Vol 12 (8) ◽  
pp. 577-587
Author(s):  
K.-H. Lu ◽  
K.-H. Lue ◽  
T.-C. Hsia ◽  
M.-C. Chou ◽  
K.-L. Lin ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sprague Dawley ◽  
Sprague Dawley Rats
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