Abstract LB-023: Describing prostate cancer heterogeneity through single cell analysis with mass cytometry

2018 ◽  
Author(s):  
Laura De Vargas Roditi ◽  
Andrea Jacobs ◽  
Christian Fankhauser ◽  
Cedric Poyet ◽  
Peter Wild ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Cell ◽  
Single Cell Analysis ◽  
Cell Analysis ◽  
Mass Cytometry ◽  
Cancer Heterogeneity

A clinically applicable strategy to concurrently profile prostate cancer (PCa) in circulation and bone using high-definition single cell analysis (HD-SCA).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 5041-5041
Author(s):  
Amado J. Zurita ◽  
Anders Carlsson ◽  
Madelyn S. Luttgen ◽  
Kelly Bethel ◽  
Patricia Troncoso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Single Cell ◽  
Single Cell Analysis ◽  
Cell Analysis ◽  
High Definition

Single Cell Analysis of Human Tissues and Solid Tumors with Mass Cytometry

2017 ◽  
Author(s):  
Nalin Leelatian ◽  
Deon B. Doxie ◽  
Allison R. Greenplate ◽  
Bret C. Mobley ◽  
Jonathan M. Lehman ◽  
...  
Keyword(s):  
Single Cell ◽  
Solid Tumors ◽  
Single Cell Analysis ◽  
Human Tissues ◽  
Cell Analysis ◽  
Mass Cytometry

scholarly journals Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Xueqi Yan ◽  
Yinghong Xie ◽  
Fan Yang ◽  
Yijia Hua ◽  
Tianyu Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Cell ◽  
Single Cell Analysis ◽  
Phenotypic Diversity ◽  
Cell Analysis ◽  
Mass Cytometry ◽  
Comprehensive Description ◽  
Infiltrating Cells ◽  
Tumoral Cells

AbstractBreast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment (TME) and influence the progression of breast cancer and the therapeutic responses in patients. The exact composition of the intra-tumoral cells is mixed as the highly heterogeneous and dynamic nature of the TME. Recent advances in single-cell technologies such as single-cell DNA sequencing (scDNA-seq), single-cell RNA sequencing (scRNA-seq) and mass cytometry have provided new insights into the phenotypic and functional diversity of tumor-infiltrating cells in breast cancer. In this review, we have outlined the recent progress in single-cell characterization of breast tumor ecosystems, and summarized the phenotypic diversity of intra-tumoral cells and their potential prognostic relevance.

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