Abstract 4348: Cardiorespiratory fitness levels in men who develop prostate cancer and its association with all-cause mortality

2020 ◽  
Author(s):  
Cara Reiter-Brennan ◽  
Omar Dzaye ◽  
Mouaz H. Al-Mallah ◽  
Zeina Dardari ◽  
Clinton A. Brawner ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cardiorespiratory Fitness ◽  
Develop Prostate Cancer ◽  
All Cause Mortality ◽  
Fitness Levels

scholarly journals Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tomas I. Gonzales ◽  
Kate Westgate ◽  
Tessa Strain ◽  
Stefanie Hollidge ◽  
Justin Jeon ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Maximal Oxygen Consumption ◽  
Estimation Method ◽  
The Novel ◽  
Exercise Tests ◽  
Metabolic Equivalent ◽  
Fitness Assessment ◽  
Disease Outcomes ◽  
All Cause Mortality ◽  
The Uk

AbstractCardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen consumption, VO2max) from heart rate response to low-risk personalised exercise tests. We apply the method to examine associations between CRF and health outcomes in the UK Biobank study, one of the world’s largest and most inclusive studies of CRF, showing that risk of all-cause mortality is 8% lower (95%CI 5–11%, 2670 deaths among 79,981 participants) and cardiovascular mortality is 9% lower (95%CI 4–14%, 854 deaths) per 1-metabolic equivalent difference in CRF. Associations obtained with the novel validated CRF estimation method are stronger than those obtained using previous methodology, suggesting previous methods may have underestimated the importance of fitness for human health.

scholarly journals The Association Between Midlife Cardiorespiratory Fitness Levels and Later-Life Dementia

2013 ◽  
Vol 158 (3) ◽  
pp. 162 ◽  
Author(s):  
Laura F. DeFina ◽  
Benjamin L. Willis ◽  
Nina B. Radford ◽  
Ang Gao ◽  
David Leonard ◽  
...  
Keyword(s):  
Cardiorespiratory Fitness ◽  
Later Life ◽  
Fitness Levels

scholarly journals Separate Associations of Intrinsic and Acquired Cardiorespiratory Fitness on All-Cause Mortality

2018 ◽  
Vol 50 (5S) ◽  
pp. 78
Author(s):  
Louise de Lannoy ◽  
Xuemei Sui ◽  
Steven N. Blair ◽  
Robert Ross
Keyword(s):  
Cardiorespiratory Fitness ◽  
All Cause Mortality

scholarly journals Ethnic Pharmacogenomic Differences in the Management of Asian Patients with Metastatic Prostate Cancer

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 407
Author(s):  
Darren M. C. Poon ◽  
Kuen Chan ◽  
Tim Chan ◽  
Foo-Yiu Cheung ◽  
Daisy Lam ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Ethnic Differences ◽  
Genetic Factors ◽  
Serious Adverse Events ◽  
Pharmacological Management ◽  
Asian Ethnicity ◽  
Asian Patients ◽  
Develop Prostate Cancer ◽  
Drug Tolerability ◽  
Systemic Therapies

Progression to metastatic disease occurs in about half of all men who develop prostate cancer (PC), one of the most common cancers in men worldwide. Androgen deprivation therapy has been the mainstay therapy for patients with metastatic PC (mPC) since the 1940s. In the last decade, there has been unprecedented advancement in systemic therapies, e.g., taxane, androgen-signalling pathway inhibitors, and biomarker-driven targeted therapies for various stages of disease, resulting in overall survival improvement. Adding to ongoing controversies over how best to treat these patients is the recognition that ethnicity may influence prognosis and outcomes. This review discusses recent evidence for the impacts of Asian ethnicity specifically, which includes environmental, sociocultural, and genetic factors, on the approach to pharmacological management of mPC. Clear inter-ethnic differences in drug tolerability, serious adverse events (AEs), and genetic heterogeneity must all be considered when dosing and scheduling for treatment, as well as designing future precision studies in PC.

Association of Multiple Adiposity Exposures and Cardiorespiratory Fitness With All-Cause Mortality in Men: The Cooper Center Longitudinal Study

2014 ◽  
Vol 89 (6) ◽  
pp. 772-780 ◽  
Author(s):  
Stephen W. Farrell ◽  
Carrie E. Finley ◽  
Allen W. Jackson ◽  
Gloria L. Vega ◽  
James R. Morrow
Keyword(s):  
Longitudinal Study ◽  
Cardiorespiratory Fitness ◽  
All Cause Mortality

scholarly journals Effectiveness of Androgen-Deprivation Therapy and Radiotherapy for Older Men With Locally Advanced Prostate Cancer

2015 ◽  
Vol 33 (7) ◽  
pp. 716-722 ◽  
Author(s):  
Justin E. Bekelman ◽  
Nandita Mitra ◽  
Elizabeth A. Handorf ◽  
Robert G. Uzzo ◽  
Stephen A. Hahn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Propensity Score ◽  
Advanced Prostate Cancer ◽  
Randomized Trials ◽  
Locally Advanced ◽  
The Elderly ◽  
Locally Advanced Prostate Cancer ◽  
High Risk Prostate Cancer ◽  
All Cause Mortality ◽  
Risk Prostate Cancer

Purpose We examined whether the survival advantage of androgen-deprivation therapy with radiotherapy (ADT plus RT) relative to ADT alone for men with locally advanced prostate cancer reported in two randomized trials holds in real-world clinical practice and extended the evidence to patients poorly represented in the trials. Methods We conducted nonrandomized effectiveness studies of ADT plus RT versus ADT in three groups of patients diagnosed between 1995 and 2007 and observed through 2009 in the SEER-Medicare data set: (1) the randomized clinical trial (RCT) cohort, which included men age 65 to 75 years and was most consistent with participants in the randomized trials; (2) the elderly cohort, which included men age > 75 years with locally advanced prostate cancer; and (3) the screen-detected cohort, which included men age ≥ 65 years with screen-detected high-risk prostate cancer. We evaluated cause-specific and all-cause mortality using propensity score, instrumental variable (IV), and sensitivity analyses. Results In the RCT cohort, ADT plus RT was associated with reduced cause-specific and all-cause mortality relative to ADT alone (cause-specific propensity score–adjusted hazard ratio [HR], 0.43; 95% CI, 0.37 to 0.49; all-cause propensity score–adjusted HR, 0.63; 95% CI, 0.59 to 0.67). Effectiveness estimates for the RCT cohort were not significantly different from those from randomized trials (P > .1). In the elderly and screen-detected cohorts, ADT plus RT was also associated with reduced cause-specific and all-cause mortality. IV analyses produced estimates similar to those from propensity score–adjusted methods. Conclusion Older men with locally advanced or screen-detected high-risk prostate cancer who receive ADT alone risk decrements in cause-specific and overall survival.

A phase II randomized controlled trial of exercise on biochemical progression in men with prostate cancer on active surveillance.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 5080-5080
Author(s):  
Dong-Woo Kang ◽  
Adrian S. Fairey ◽  
Normand G. Boulé ◽  
Catherine J. Field ◽  
Stephanie A. Wharton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomized Controlled Trial ◽  
Physical Fitness ◽  
Disease Progression ◽  
Active Surveillance ◽  
Cardiorespiratory Fitness ◽  
Controlled Trial ◽  
Mean Difference ◽  
Randomized Controlled ◽  
Biochemical Progression

5080 Background: Men with prostate cancer (PCa) undergoing active surveillance (AS) are at increased risks of cardiovascular death and disease progression. Any intervention that can address these issues during AS would be highly beneficial. Clinical and preclinical studies have demonstrated the benefits of exercise to improve cardiovascular health in cancer patients and suggested the potential role of exercise in suppressing PCa progression in men with PCa undergoing AS. Therefore, the purpose of this study was to investigate the effects of exercise on cardiorespiratory fitness and biochemical progress of PCa in men with PCa on AS. Methods: The Exercise During Active Surveillance for Prostate Cancer (ERASE) Trial was a single-centre, two-armed, randomized controlled trial in Edmonton, Canada. 52 men with localized PCa who were undergoing AS were randomized to high-intensity interval training (HIIT; n = 26) or usual care (UC; n = 26). The HIIT group performed thrice-weekly, supervised, aerobic HIIT on a treadmill at 85-95% of peak cardiorespiratory fitness (VO2peak) for 12 weeks. The primary outcome was VO2peak, and the secondary and exploratory outcomes included biochemical progression of PCa (prostate-specific antigen [PSA]), PSA kinetics, and growth of prostate cancer cell line LNCaP. Results: 46/52 participants (88%) completed the postintervention VO2peak assessment and adherence to HIIT was 96%. Compared to UC, HIIT significantly improved VO2peak (adjusted between-group mean difference, 1.6 ml·kg-1·min-1; 95% confidence interval [CI], 0.3 to 2.9; p= 0.014). HIIT also significantly reduced PSA level (adjusted between-group mean difference, -1.1 ug/L; 95% CI, -2.1 to 0.0; p= 0.043) and PSA velocity ( p= 0.040), and suppressed LNCaP cell growth ( p =0.024). No significant differences were found in PSA doubling time ( p= 0.10) and testosterone ( p= 0.24). Conclusions: The ERASE Trial is the first randomized controlled trial to demonstrate the impact of HIIT exercise for improving physical fitness and inhibiting biochemical progression of PCa in men with localized PCa on AS. Our findings suggest that supervised aerobic HIIT may be a promising intervention in this clinical setting. Larger-scale randomized controlled trials are warranted to determine if improvements in physical fitness and PCa-related markers translate into improved long-term clinical outcomes in these men such as disease progression, receipt of radical treatments, posttreatment complications, and survival. Clinical trial information: NCT03203460.

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