Abstract 878: Contraceptive use and ovarian cancer risk inBRCA1andBRCA2mutation carriers: A prospective cohort study

Author(s):  
Yue Yin Xia ◽  
Jan Lubinski ◽  
Barry Rosen ◽  
Pal Moller ◽  
Andrea Eisen ◽  
...  
2007 ◽  
Vol 18 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Stephanie A. N. Silvera ◽  
Meera Jain ◽  
Geoffrey R. Howe ◽  
Anthony B. Miller ◽  
Thomas E. Rohan

2017 ◽  
Vol 28 (5) ◽  
pp. 371-383 ◽  
Author(s):  
Amy L. Shafrir ◽  
Helena Schock ◽  
Elizabeth M. Poole ◽  
Kathryn L. Terry ◽  
Rulla M. Tamimi ◽  
...  

2018 ◽  
Vol 55 (8) ◽  
pp. 546-554 ◽  
Author(s):  
Xin Yang ◽  
Goska Leslie ◽  
Aleksandra Gentry-Maharaj ◽  
Andy Ryan ◽  
Maria Intermaggio ◽  
...  

BackgroundGenome-wide association studies have identified >30 common SNPs associated with epithelial ovarian cancer (EOC). We evaluated the combined effects of EOC susceptibility SNPs on predicting EOC risk in an independent prospective cohort study.MethodsWe genotyped ovarian cancer susceptibility single nucleotide polymorphisms (SNPs) in a nested case–control study (750 cases and 1428 controls) from the UK Collaborative Trial of Ovarian Cancer Screening trial. Polygenic risk scores (PRSs) were constructed and their associations with EOC risk were evaluated using logistic regression. The absolute risk of developing ovarian cancer by PRS percentiles was calculated.ResultsThe association between serous PRS and serous EOC (OR 1.43, 95% CI 1.29 to 1.58, p=1.3×10–11) was stronger than the association between overall PRS and overall EOC risk (OR 1.32, 95% CI 1.21 to 1.45, p=5.4×10–10). Women in the top fifth percentile of the PRS had a 3.4-fold increased EOC risk compared with women in the bottom 5% of the PRS, with the absolute EOC risk by age 80 being 2.9% and 0.9%, respectively, for the two groups of women in the population.ConclusionPRSs can be used to predict future risk of developing ovarian cancer for women in the general population. Incorporation of PRSs into risk prediction models for EOC could inform clinical decision-making and health management.


2002 ◽  
Author(s):  
A. R. Aro ◽  
H. J. de Koning ◽  
K. Vehkalahti ◽  
P. Absetz ◽  
M. Schreck ◽  
...  

2012 ◽  
Vol 95 (5) ◽  
pp. 1172-1181 ◽  
Author(s):  
Marieke GM Braem ◽  
N Charlotte Onland-Moret ◽  
Leo J Schouten ◽  
Anne Tjønneland ◽  
Louise Hansen ◽  
...  

2007 ◽  
Vol 58 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Stephanie A. N. Silvera ◽  
Meera Jain ◽  
Geoffrey R. Howe ◽  
Anthony B. Miller ◽  
Thomas E. Rohan

2016 ◽  
Vol 5 (8) ◽  
pp. 2136-2144 ◽  
Author(s):  
Trude E. Robsahm ◽  
Ragnhild S. Falk ◽  
Trond Heir ◽  
Leiv Sandvik ◽  
Linda Vos ◽  
...  

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