Abstract IA10: Neuroblastoma is a biphasic tumor

2018 ◽  
Author(s):  
Rogier Versteeg ◽  
Tim van Groningen ◽  
Jan Koster ◽  
Linda J. Valentijn ◽  
Johan van Nes
Keyword(s):  
Biphasic Tumor

Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cell Population ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Biphasic Tumor ◽  
Carcinoma Of The Tongue ◽  
Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

Rare case of biphasic tumor of the breast with prominent CD34-positive spindle cells

2001 ◽  
Vol 51 (9) ◽  
pp. 713-717
Author(s):  
Masahiro Hayashi ◽  
Gen Tamura ◽  
Osamu Matsumoto ◽  
Teiichi Motoyama
Keyword(s):  
Rare Case ◽  
Spindle Cells ◽  
Biphasic Tumor

Malignant biphasic tumor of the uterus: A case report and review

2013 ◽  
Vol 12 (5) ◽  
pp. 249-251
Author(s):  
Umesh Das ◽  
Vishwanath Sathyanarayanan ◽  
Nagesh Taterao Sirsath ◽  
G. Champaka ◽  
Lakshmaiah Kuntejowdahalli Channaviriappa
Keyword(s):  
Case Report ◽  
Biphasic Tumor

Sarcomatoid Carcinoma of the Colon: A Case Report with Literature Review

2001 ◽  
Vol 87 (6) ◽  
pp. 431-435 ◽  
Author(s):  
Dolores Di Vizio ◽  
Luigi Insabato ◽  
Giovanni Conzo ◽  
Brian T Zafonte ◽  
Gerardo Ferrara ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Small Intestine ◽  
Case Report ◽  
Sarcomatoid Carcinoma ◽  
Clinical History ◽  
Tumor Type ◽  
Carcinoma Of The Colon ◽  
Therapeutic Implications ◽  
Immunohistochemical Analyses ◽  
Biphasic Tumor

Sarcomatoid carcinoma (SC) is a well defined tumor type that may occur in all organs and anatomic sites but most commonly in the head1, neck1, respiratory tract2-4, breast5, and genitourinary tract6-11. It is a biphasic tumor showing both epithelial- and mesenchymal-like differentiation; however, its carcinomatous nature is widely recognized12. SC is rare in the gastrointestinal tract. In the esophagus it accounts for less than 5% of all malignancies12-16 and approximately only 35 cases have been described in the stomach12,17-18. Very few cases have been observed in the small intestine19-20, anorectal junction21, liver22, and pancreas23-24. To our knowledge only eight cases of SC have been reported in the colon25-32. We report a case of primary colonic SC. Both morphological and immunohistochemical analyses are provided along with an evaluation of the unusual clinical history, therapeutic implications, and controversial differential diagnosis.

scholarly journals Temporal primary cutaneous carcinosarcoma in the ear: A case report

2021 ◽  
Vol 12 (2) ◽  
pp. 180-182
Author(s):  
Issam Msakni ◽  
Aya Khemir ◽  
Nada Mansouri
Keyword(s):  
Case Report ◽  
Smooth Muscle Actin ◽  
The Body ◽  
Muscle Actin ◽  
Epithelial Component ◽  
Spindle Cells ◽  
Stromal Component ◽  
Peripheral Palisading ◽  
Biphasic Tumor

Carcinosarcoma is a rare biphasic tumor made of two malignant components—the epithelial component and the stromal component—that can develop anywhere on the body, but mainly in sun-exposed areas. We report the case of a 78-year-old male who presented himself with a right temporal tumor in the ear 10 cm in diameter. A biopsy suggested a sarcoma. The patient underwent an extensive surgical resection of the temporal mass and the ipsilateral ear. A microscopic examination of the tumor revealed two intermixed malignant contingents. The epithelial component was made of atypical basaloid cells arranged in nests with peripheral palisading and expressing cytokeratin. The stromal component was made of atypical spindle cells expressing smooth muscle actin (SMA). A diagnosis of primary cutaneous carcinosarcoma with clear margins was reached. The patient is alive and without recurrence after twelve months of a follow-up period.

Metastatic Leydig Cell Tumor With Sarcomatoid Differentiation

1999 ◽  
Vol 123 (11) ◽  
pp. 1104-1107 ◽  
Author(s):  
H. Evin Gulbahce ◽  
Arthur T. Lindeland ◽  
William Engel ◽  
Tamera J. Lillemoe
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Fat Tissue ◽  
The Right ◽  
Initial Metastasis ◽  
Leydig Cell Tumors ◽  
Perirenal Fat ◽  
Biphasic Tumor ◽  
Sarcomatoid Differentiation

Abstract Leydig cell tumors of the testis are uncommon. Only about 10% of cases have a malignant course. It has been stated that the only definite criterion for malignancy is presence of metastasis. We present a 47-year-old patient with metastatic Leydig cell tumor 17 years after initial diagnosis, to our knowledge the longest reported interval between diagnosis and the development of metastasis. The primary tumor did not exhibit convincing features of malignancy. The initial metastasis in the right perirenal fat tissue showed a biphasic tumor with sarcomatoid differentiation not described previously in a metastatic Leydig cell tumor.

A Biphasic Tumor of the Mediastinum with Features of Synovial Sarcoma

1989 ◽  
Vol 13 (6) ◽  
pp. 490-499 ◽  
Author(s):  
Gary B. Witkin ◽  
Markku Miettinen ◽  
Juan Rosai
Keyword(s):  
Synovial Sarcoma ◽  
Biphasic Tumor

scholarly journals Uterine Adenosarcoma

2016 ◽  
Vol 140 (3) ◽  
pp. 286-290 ◽  
Author(s):  
Andre Pinto ◽  
Brooke Howitt
Keyword(s):  
Prognostic Factors ◽  
Molecular Biology ◽  
Stromal Cells ◽  
Spindle Cell ◽  
Myometrial Invasion ◽  
Spindle Cell Sarcoma ◽  
Low Grade ◽  
Cell Sarcoma ◽  
Phyllodes Tumors ◽  
Biphasic Tumor

Müllerian adenosarcoma is an uncommon biphasic tumor composed of malignant stromal and benign epithelial components. Morphologically, adenosarcoma is characterized by a broad leaflike architecture, reminiscent of phyllodes tumors of the breast. Periglandular cuffing of the stromal cells around the compressed or cystically dilated glands is characteristic. The mesenchymal component is typically a low-grade spindle cell sarcoma, whereas the epithelial counterpart is commonly endometrioid with frequent squamous or mucinous metaplasia and may, in some circumstances, show mild to moderate atypia. In all cases, it is important to assess for the presence of sarcomatous overgrowth and myometrial invasion, which are the prognostic factors. In this brief review, we present the clinical, histopathologic, and immunohistochemical features of adenosarcoma, as well as updates on the molecular biology of this neoplasm.

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