Abstract P3-01-07: Comparison of the prognostic value of lymph node ratio versus residual lymph node status in triple negative breast cancer

2018 ◽  
Author(s):  
G De la Cruz-Ku ◽  
Z Morante ◽  
J Pinto ◽  
D Enriquez ◽  
E Eyzaguirre ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Triple Negative ◽  
Lymph Node Status ◽  
Node Status ◽  
Node Ratio ◽  
Ratio Versus

scholarly journals Pilot Study on MAGE-C2 as a Potential Biomarker for Triple-Negative Breast Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Qian Zhao ◽  
Wen-ting Xu ◽  
Tuluhong Shalieer
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Triple Negative Breast Cancer ◽  
Lymphovascular Invasion ◽  
Triple Negative ◽  
Tnm Stage ◽  
Clinicopathological Parameters ◽  
Lymph Node Status ◽  
Node Status ◽  
Expression Status

Objective. In the current study, we measured the expression status of melanoma antigen gene c2 (MAGE-C2) in triple-negative breast cancer (TNBC) and analyzed its prognostic with the clinical pathological features of patients with TNBC. Methods. The expressions statuses of MAGE-C2 were detected in TNBC tissues and paracarcinoma tissues by immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR), and western blotting. Then, we investigated the relationship of MAGE-C2 expression status and clinicopathological parameters of TNBC patients by the chi-squared test. Finally, we discussed the relations of MAGE-C2 expression state and prognosis of patients with TNBC by Kaplan-Meier method and Cox proportional hazards model. Results. High MAGE-C2 expression was found in 38.18% (42/110) of TNBC tissues. In adjacent tissues it was 9.09% (10/110). High MAGE-C2 expression in TNBC patients was closely associated with lymph node status, tumor node metastasis (TNM) stage, and lymphovascular invasion (P<0.001). TNBC patients with high MAGE-C2 expression had significantly shorter survival time than low expression patients. We also found that age, lymph node status, TNM stage, lymphovascular invasion, and MAGE-C2 expression status were closely associated with overall survival of TNBC patients (P<0.05). Conclusion. High MAGE-C2 expression may serve as an independent prognostic factor for TNBC patients.

scholarly journals The lymph node ratio as an independent prognostic factor for node-positive triple-negative breast cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (27) ◽  
pp. 44870-44880 ◽  
Author(s):  
Min He ◽  
Jia-Xin Zhang ◽  
Yi-Zhou Jiang ◽  
Ying-Le Chen ◽  
Hai-Yuan Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Triple Negative Breast Cancer ◽  
Lymph Node Ratio ◽  
Triple Negative ◽  
Independent Prognostic Factor ◽  
Node Positive ◽  
Node Ratio

The Impact of Lymphovascular Invasion on Lymph Node Status in Patients with Breast Cancer

2011 ◽  
Vol 77 (7) ◽  
pp. 874-877 ◽  
Author(s):  
Laura B. Cornwell ◽  
Kelly M. Mcmasters ◽  
Anees B. Chagpar
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymphovascular Invasion ◽  
Lymph Node Ratio ◽  
Lymph Node Status ◽  
Sentinel Nodes ◽  
Node Positive ◽  
Node Status ◽  
Node Ratio ◽  
The Impact

Lymphovascular invasion (LVI) is not uniformly found or reported in breast cancer tumor reports. We sought to determine the impact of the finding of LVI on various parameters of lymph node status in patients with breast cancer. A chart review was performed of 400 node-positive patients from a cohort of patients in a prospective multicenter national sentinel node registry. The finding of LVI was then correlated to number of positive sentinel nodes, the number of positive non-sentinel nodes, the lymph node ratio, and the size of the largest metastatic deposit. Of the 400 patients, data regarding LVI were missing in 98 (24.5%) cases. Although all of these patients were node-positive, LVI was noted to be present in 155 patients (38.8%) and absent in 147 (36.8%). LVI was found to correlate with more positive sentinel nodes (mean, 1.72 vs 1.35; P < 0.001), more positive nonsentinel nodes (mean, 2.16 vs 0.54; P < 0.001), and a higher lymph node ratio (0.29 vs 0.16; P < 0.001). LVI also correlated with size of largest metastatic deposit ( P = 0.002). Although LVI is known to be associated with lymph node status, it is not frequently noted on pathology reports. Given its prognostic value, LVI should be carefully evaluated and reported.

scholarly journals Prognostic Value of Androgen Receptor in Triple Negative Breast Cancer of Iranian Patients in Yazd Region

2020 ◽  
pp. 164-167
Author(s):  
Fatemeh Alsadat Nobakht ◽  
Mansour Moghimi
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Androgen Receptor ◽  
High Risk ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Tumor Location ◽  
Lymph Node Status ◽  
Ki 67

Background: Triple negative breast cancer (TNBC) is a heterogeneous disease group with a higher recurrence risk and poorer prognosis. In this study, we aimed to investigate the frequency and prognostic value of androgen receptor (AR) expression in tissues of TNBC patients.Methods: In this study a total of 60 TNBC patients treated between 2011 - 2016 in Shahid Sadoughi and Mortaz Hospital were included and their medical records were analyze. The available paraffin blocks were assessed immunohistochemically to determine AR expression. Tumors with ?10% nuclear staining were considered AR-positive, while the ones with <10% staining were considered AR-negative. The association between AR expression, and clinical-pathologic characteristics and prognosis in TNBC was analyzed. Results: The result showed that AR expression in TBNC correlated with high risk of recurrence but no significant correlation with the age, grade, tumor size, lymph node status, type of diagnosis, tumor location, and Ki-67 level was observed. Positive immunoreactivity for AR was observed in 19 out of 60 (11%) specimens. No correlation was observed between the AR expression and the age, grade, tumor size, lymph node status, type of diagnosis, tumor location, and Ki-67 level. The AR-positive patients exhibited high risk of recurrence (P=0.016) and death (P=0.015) in comparison with the AR-negative patients. Concusions: AR may not be a suitable biomarker and treatment target for the Iranian Yazd patients with TNBC.

scholarly journals Nomogram for Predicting Lymph Node Involvement in Triple-Negative Breast Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Xiang Cui ◽  
Hao Zhu ◽  
Jisheng Huang
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Predictive Factors ◽  
Operating Characteristic ◽  
Triple Negative ◽  
Lymph Node Status ◽  
Multivariate Logistic Regression ◽  
Receiver Operating Characteristic Curves ◽  
Node Metastasis ◽  
Node Status

BackgroundLymph node metastasis of triple-negative breast cancer (TNBC) is essential in treatment strategy formulation. This study aimed to build a nomogram that predicts lymph node metastasis in patients with TNBC.Materials and MethodsA total of 28,966 TNBC patients diagnosed from 2010 to 2017 in the Surveillance, Epidemiology and End Results (SEER) database were enrolled, and randomized 1:1 into the training and validation sets, respectively. Univariate and multivariate logistic regression analysis were applied to identify the predictive factors, which composed the nomogram. The receiver operating characteristic curves showed the efficacy of the nomogram.ResultMultivariate logistic regression analyses revealed that age, race, tumor size, tumor primary site, and pathological grade were independent predictive factors of lymph node status. Integrating these independent predictive factors, a nomogram was successfully developed for predicting lymph node status, and further validated in the validation set. The areas under the receiver operating characteristic curves of the nomogram in the training and validation sets were 0.684 and 0.689 respectively, showing a satisfactory performance.ConclusionWe constructed a nomogram to predict the lymph node status in TNBC patients. After further validation in additional large cohorts, the nomogram developed here would do better in predicting, providing more information for staging and treatment, and enabling tailored treatment in TNBC patients.

The Impact of the Lymph Node Ratio is Greater than Traditional Lymph Node Status in Stage III Colorectal Cancer Patients

2013 ◽  
Vol 37 (8) ◽  
pp. 1927-1933 ◽  
Author(s):  
Yen-Jung Lu ◽  
Pei-Ching Lin ◽  
Chun-Chi Lin ◽  
Huann-Sheng Wang ◽  
Shung-Haur Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Lymph Node Status ◽  
Node Status ◽  
Node Ratio ◽  
Colorectal Cancer Patients ◽  
The Impact
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