Abstract PS7-63: Cause of death discordance between death certificates and medical files: Impact on cancer survival assessment in a Belgian case study

2021 ◽  
Author(s):  
Hava Izci ◽  
Tim Tambuyzer ◽  
Jessica Vandeven ◽  
Jérôme Xicluna ◽  
Hans Wildiers ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Cancer Survival ◽  
Death Certificates

scholarly journals Cause of death for patients with breast cancer: discordance between death certificates and medical files, and impact on survival estimates

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Hava Izci ◽  
Tim Tambuyzer ◽  
Jessica Vandeven ◽  
Jérôme Xicluna ◽  
Hans Wildiers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cause Of Death ◽  
Cancer Survival ◽  
False Negative ◽  
Relative Survival ◽  
Death Certificates ◽  
Breast Cancer Patients ◽  
University Hospitals ◽  
Kappa Value

Abstract Background Registration and coding of cause of death is prone to error since determining the exact underlying condition leading directly to death is challenging. In this study, causes of death from the death certificates were compared to patients’ medical files interpreted by experts at University Hospitals Leuven (UHL), to assess concordance between sources and its impact on cancer survival assessment. Methods Breast cancer patients treated at UHL (2009–2014) (follow-up until December 31st 2016) were included in this study. Cause of death was obtained from death certificates and expert-reviewed medical files at UHL. Agreement was calculated using Cohen’s kappa coefficient. Cause-specific survival (CSS) was calculated using the Kaplan-Meier method and the relative survival probability (RS) using the Ederer II and Pohar Perme method. Results A total of 2862 patients, of whom 354 died, were included. We found an agreement of 84.7% (kappa-value of 0.69 (95% C.I.: 0.62–0.77)) between death certificates and medical files. Death certificates had 10.7% false positive and 4.5% false negative rates. However, five-year CSS and RS measures were comparable for both sources. Conclusion For breast cancer patients included in our study, fair agreement of cause of death was seen between death certificates and medical files with similar CSS and RS estimations.

Cause of death in judicial hanging: a review and case study

2009 ◽  
Vol 49 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Catherine Hellier ◽  
Robert Connolly
Keyword(s):  
Cause Of Death

scholarly journals Gastrointestinal Manifestations in Mucopolysaccharidosis Type III: Review of Death Certificates and the Literature

2021 ◽  
Vol 10 (19) ◽  
pp. 4445
Author(s):  
Sophie Thomas ◽  
Uma Ramaswami ◽  
Maureen Cleary ◽  
Medeah Yaqub ◽  
Eva M. Raebel
Keyword(s):  
Cause Of Death ◽  
Causes Of Death ◽  
Clinical Feature ◽  
Mucopolysaccharidosis Type ◽  
Death Certificates ◽  
Type Iii ◽  
Mucopolysaccharidosis Type Iii ◽  
Gi Symptoms ◽  
Tract Infections ◽  
Mps Iii

Background: Mucopolysaccharidosis type III (MPS III, Sanfilippo disease) is a life-limiting recessive lysosomal storage disorder caused by a deficiency in the enzymes involved in degrading glycosaminoglycan heparan sulfate. MPS III is characterized by progressive deterioration of the central nervous system. Respiratory tract infections have been reported as frequent and as the most common cause of death, but gastrointestinal (GI) manifestations have not been acknowledged as a cause of concern. The aim of this study was to determine the incidence of GI problems as a primary cause of death and to review GI symptoms reported in published studies. Methods: Causes of death from 221 UK death certificates (1957–2020) were reviewed and the literature was searched to ascertain reported GI symptoms. Results: GI manifestations were listed in 5.9% (n = 13) of death certificates. Median (IQR) age at death was 16.7 (5.3) years. Causes of death included GI failure, GI bleed, haemorrhagic pancreatitis, perforation due to gastrostomies, paralytic ileus and emaciation. Twenty-one GI conditions were reported in 30 studies, mostly related to functional GI disorders, including diarrhoea, dysphagia, constipation, faecal incontinence, abdominal pain/distension and cachexia. Conclusions: GI manifestations may be an under-recognized but important clinical feature of MPS III. Early recognition of GI symptoms and timely interventions is an important part of the management of MPS III patients.

Secondary Prevention 1: Cancers and Principles of Screening

2010 ◽  
pp. 141-157
Author(s):  
Martha P. Millman ◽  
Paul J. Limburg
Keyword(s):  
United States ◽  
Cause Of Death ◽  
Cancer Survival ◽  
Task Force ◽  
The United States ◽  
Screening Tests ◽  
Evidence Based ◽  
Level Of Education ◽  
Screening Strategies ◽  
Evidence Based Guidelines

Screening tests are used to differentiate between persons with and without the condition of interest in a defined population. Screening strategies, or mass screening, is applied relatively indiscriminately to a population. Cancer is the second-leading overall cause of death in the United States; however, it is the leading cause of death for those under 85. Cancer risk is associated with environmental risk factors. Racial disparities in cancer incidence and death persist in the United States; level of education also appears to affect cancer survival. The United States Preventive Services Task Force has established evidence-based guidelines for screening, counseling, and chemoprevention.

scholarly journals Querying of Death Certificates in the United States

2005 ◽  
Vol 120 (3) ◽  
pp. 288-293 ◽  
Author(s):  
Donna L. Hoyert ◽  
Ann R. Lima
Keyword(s):  
United States ◽  
New York ◽  
Incomplete Information ◽  
Cause Of Death ◽  
The United States ◽  
Death Certificates ◽  
Death Rates ◽  
Underlying Cause Of Death ◽  
The Impact ◽  
Registration Area

Objective. Data from death certificates are often used in research; however, little has been published on the processing of vague or incomplete information reported on certificates. The goal of this study was to examine the querying efforts in the United States used to clarify such records. Methods. The authors obtained data on the querying efforts of the 50 states, New York City, and the District of Columbia. Descriptive statistics are presented for two units of analysis: registration area and death record. Using data from a single registration area, Washington State, the authors compared the percent change in age-adjusted death rates for data from before and after querying to analyze the effect of querying on selected causes of death. Results. Fifty-one of the 52 registration areas queried either demographic or cause-of-death information. Almost 90% of queries were returned; the underlying cause of death changed in approximately 68% of these records. This data translates into about 3% of total U.S. death records, given that 4% of total U.S. death records were queried about cause of death. The impact of queries on age-adjusted death rates varied by cause of death. Generally, the effect is most obvious for cause-of-death categories that are specific and relatively homogenous. Conclusion. Querying continues to be widely practiced. In the case of cause-of-death queries, this method refines the assigned underlying cause of death for records reported with vague or incomplete information.

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