Abstract B09: Serum vitamin D levels in breast cancer patients to assess its risk prediction to improve health

2017 ◽  
Author(s):  
Vinit Mehrotra ◽  
Ashutosh Sharma
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Risk Prediction ◽  
Serum Vitamin ◽  
Breast Cancer Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Improve Health

Prognostic characteristics of 492 newly diagnosed breast cancer patients by serum vitamin D levels.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12619-e12619 ◽  
Author(s):  
Luke Joseph Peppone ◽  
Mohamedtaki Abdulaziz Tejani ◽  
Karen Michelle Mustian ◽  
Michelle Christine Janelsins ◽  
Charles Stewart Kamen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Serum Vitamin ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals The association between fat mass and obesity‐associated ( FTO ) genotype and serum vitamin D level in breast cancer patients

2021 ◽  
Vol 25 (20) ◽  
pp. 9627-9633
Author(s):  
Maryam Gholamalizadeh ◽  
Zohreh Mokhtari ◽  
Saeid Doaei ◽  
Vahideh Jalili ◽  
Sayed Hossein Davoodi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Fat Mass ◽  
Serum Vitamin ◽  
Breast Cancer Patients ◽  
Serum Vitamin D

scholarly journals Impact of serum vitamin D on the response and prognosis in breast cancer patients treated with neoadjuvant chemotherapy

Breast Cancer ◽  
2021 ◽  
Author(s):  
Eriko Tokunaga ◽  
Takanobu Masuda ◽  
Hideki Ijichi ◽  
Wakako Tajiri ◽  
Chinami Koga ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Clinical Stage ◽  
Univariate Analysis ◽  
Serum Vitamin ◽  
Breast Cancer Patients ◽  
Serum Vitamin D ◽  
Low Serum

Abstract Background Several studies have recently reported that the relationships between serum vitamin D and the prognosis or the pathological response to neoadjuvant chemotherapy (NAC) in breast cancer. However, there are no data regarding the clinical impacts of the vitamin D in Japanese breast cancer patients so far. Patients and methods In the present study, a total of 250 patients with clinical Stage I–III primary breast cancer who were treated with NAC and subsequently underwent definitive surgery were included. Serum 25-hydroxvitamin D (25(OH)D) levels were evaluated using blood samples obtained before NAC. Results The serum 25(OH)D was positively associated with age, and the serum 25(OH)D was significantly higher in postmenopausal women than that in pre/peri-menopausal women. Serum 25(OH)D level was not associated with the achievement of pathological complete response (pCR) in this cohort. The low 25(OH)D levels were significantly associated with shorter time to distant recurrence (TTDR). According to the univariate analysis, high clinical stage before NAC (cStage III) and low serum 25(OH)D level were significantly associated with the shorter TTDR, and pCR was significantly associated with the longer TTDR. According to a multivariate analysis, low serum 25(OH)D level were independent poor prognostic factors for TTDR. Conclusions The low 25(OH)D levels were significantly associated with poorer prognosis in Japanese women with operable breast cancer patients treated with NAC.

scholarly journals Circulating Vitamin D and Overall Survival in Breast Cancer Patients: A Dose-Response Meta-Analysis of Cohort Studies

2017 ◽  
Vol 17 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Kejia Hu ◽  
David Frederick Callen ◽  
Jiayuan Li ◽  
Hong Zheng
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Overall Survival ◽  
Cancer Patients ◽  
Dose Response ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Breast Cancer Patients ◽  
Fixed Effects Model ◽  
Vitamin D Levels

Studies have shown that vitamin D could have a role in breast cancer survival; however, the evidence of the relationship between patients’ vitamin D levels and their survival has been inconsistent. This meta-analysis explores possible dose-response relationships between vitamin D levels and overall survival by allowing for differences in vitamin D levels among populations of the various studies. Studies relating vitamin D (25-OH-D [25-hydroxyvitamin D]) levels in breast cancer patients with their survival were identified by searching PubMed and Embase. A pooled HR (hazard ratio) comparing the highest with the lowest category of circulating 25-OH-D levels were synthesized using the Mantel-Haenszel method under a fixed-effects model. A two-stage fixed-effects dose-response model including both linear (a log-linear dose-response regression) and nonlinear (a restricted cubic spline regression) models were used to further explore possible dose-response relationships. Six studies with a total number of 5984 patients were identified. A pooled HR comparing the highest with the lowest category of circulating 25-OH-D levels under a fixed-effects model was 0.67 (95% confidence interval = 0.56-0.79, P < .001). Utilizing a dose-response meta-analysis, the pooled HR for overall survival in breast cancer patients was 0.994 (per 1 nmol/L), Pfor linear trend < .001. At or above a 23.3 nmol/L threshold, for a 10 nmol/L, 20 nmol/L, or 25 nmol/L increment in circulating 25-OH-D levels, the risk of breast cancer overall mortality decreased by 6%, 12%, and 14%, respectively. There was no significant nonlinearity in the relationship between overall survival and circulating 25-OH-D levels. Our findings suggest that there is a highly significant linear dose-response relationship between circulating 25-OH-D levels and overall survival in patients with breast cancer. However, better designed prospective cohort studies and clinical trials are needed to further confirm these findings.

scholarly journals Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women

Maturitas ◽  
2018 ◽  
Vol 116 ◽  
pp. 83-88 ◽  
Author(s):  
Marta Pineda-Moncusí ◽  
Miguel Angel Garcia-Perez ◽  
Abora Rial ◽  
Guillem Casamayor ◽  
Maria Lourdes Cos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Healthy Women ◽  
Vitamin D Levels

scholarly journals Relation of Vitamin D Deficiency with Breast Cancer Staging in Patients from INMOL Cancer Hospital

2021 ◽  
Vol 35 (1) ◽  
pp. 27-32
Author(s):  
Maleeha Tahir Butt
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Carcinoma ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Stage I ◽  
Serum Vitamin D ◽  
Cancer Hospital ◽  
Vitamin D Levels ◽  
Healthy Females

Introduction: Vitamin D deficiency can be critical and is reported to be as one of the factors for development and progression of breast carcinoma. Aims & Objectives: To measure and compare 25(OH)D (calcidiol) levels in healthy females and in breast carcinoma patients in four different stages. Place and duration of study: This cross sectional study and research was conducted in Shaikh Zayed Medical Complex in the Department of Biochemistry and Chemical Pathology from Jan 2018 to Jan 2019. The patients were selected from INMOL Cancer Hospital, Lahore. Material & Methods: The study was carried out on 39 healthy females (controls) and 156 newly diagnosed cases of carcinoma breast from stage I to IV, 39 patients of each stage. 25(OH)D was determined in blood samples of patients by ADVIA Centaur (XP) immunoassay system. Results: In this study the mean 25(OH)D level of healthy females with mean age of 41.7 ± 15.8 years, was 25.1 ± 5.5ng/ml. 25(OH) D level of breast cancer patients was found to be decreasing with stage progression. For the stage I the average 25(OH)D level was 12.31ng/ml, stage II was 9 ng/ml, stage III was 8.3 ng/ml and stage IV was 8.4 ng/ml. Conclusion: It was found that healthy group of females had higher values of serum vitamin D levels as compared to breast carcinoma patients. Low concentration of serum vitamin D may contribute to the progression of stage of breast carcinoma.

Evalution of effect of Vitamin D levels and tumor Vitamin D receptor status as a risk factor and marker for therapeutic response Indian breast cancer patients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12523-e12523
Author(s):  
Kul Ranjan Singh ◽  
Abhinav Arun Sonkar ◽  
Prarthana Saxena ◽  
Jitendra Kumar Kushwaha ◽  
Akshay Anand Agarwal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Risk Factor ◽  
Cancer Patients ◽  
Vitamin D Receptor ◽  
Therapeutic Response ◽  
Breast Cancer Patients ◽  
Receptor Status ◽  
Vitamin D Levels
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