Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence

2021 ◽  
Author(s):  
Sam Garnett ◽  
Angeline de Bruyns ◽  
Veronique Provencher-Tom ◽  
Kendall Dutchak ◽  
Ran Shu ◽  
...  
Keyword(s):  
Ras Oncogene

scholarly journals Anti-Fibrotic Activity of an Antimicrobial Peptide in a Drosophila Model

2021 ◽  
pp. 1-15
Author(s):  
Dilan Khalili ◽  
Christina Kalcher ◽  
Stefan Baumgartner ◽  
Ulrich Theopold
Keyword(s):  
Antimicrobial Peptide ◽  
Cell Polarity ◽  
Active Form ◽  
Ectopic Expression ◽  
Secretory Activity ◽  
Ras Oncogene ◽  
Apicobasal Polarity ◽  
Pathological Conditions ◽  
Extracellular Matrix Components ◽  
Matrix Components

Fibrotic lesions accompany several pathological conditions, including tumors. We show that expression of a dominant-active form of the Ras oncogene in <i>Drosophila</i> salivary glands (SGs) leads to redistribution of components of the basement membrane (BM) and fibrotic lesions. Similar to several types of mammalian fibrosis, the disturbed BM attracts clot components, including insect transglutaminase and phenoloxidase. SG epithelial cells show reduced apicobasal polarity accompanied by a loss of secretory activity. Both the fibrotic lesions and the reduced cell polarity are alleviated by ectopic expression of the antimicrobial peptide drosomycin (Drs), which also restores the secretory activity of the SGs. In addition to extracellular matrix components, both Drs and F-actin localize to fibrotic lesions.

scholarly journals Reactivity of a sulfhydryl group of the ras oncogene product p21 modulated by GTP binding.

1986 ◽  
Vol 261 (31) ◽  
pp. 14582-14586 ◽  
Author(s):  
S Hattori ◽  
T Yamashita ◽  
T D Copeland ◽  
S Oroszlan ◽  
T Y Shih
Keyword(s):  
Sulfhydryl Group ◽  
Ras Oncogene ◽  
Gtp Binding

Metabolism of n-6 fatty acids by NIH-3T3 cells transfected with the ras oncogene

1994 ◽  
Vol 139 (1) ◽  
pp. 71-81 ◽  
Author(s):  
R. J. de Antueno ◽  
R. C. Cantrill ◽  
Y-S. Huang ◽  
G. W. Ells ◽  
M. Elliot ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Ras Oncogene ◽  
3T3 Cells ◽  
Nih 3T3 ◽  
Nih 3T3 Cells

Oncogene Activation in Multistage Carcinogenesis

1989 ◽  
Vol 8 (2) ◽  
pp. 241-243
Author(s):  
Seymour J. Garte
Keyword(s):  
Protease Inhibitors ◽  
In Vitro Studies ◽  
Ras Oncogene ◽  
Multistage Carcinogenesis ◽  
Oncogene Activation ◽  
Shed Light

Oncogene activation in multistage carcinogenesis is discussed. Results from a number of in vitro studies are cited. An understanding of the mechanisms that suppress activated ras oncogene-induced transformation by protease inhibitors is expected to shed light on the process of multistage carcinogenesis.

scholarly journals ras Oncogene p21 expression is increased in premalignant lesions and high grade bladder carcinoma.

1985 ◽  
Vol 161 (5) ◽  
pp. 1213-1218 ◽  
Author(s):  
M V Viola ◽  
F Fromowitz ◽  
S Oravez ◽  
S Deb ◽  
J Schlom
Keyword(s):  
Bladder Carcinoma ◽  
Premalignant Lesions ◽  
Low Grade ◽  
Staining Reaction ◽  
High Grade ◽  
Ras Oncogene ◽  
Intense Staining ◽  
Bladder Urothelium ◽  
Normal Bladder ◽  
Ras P21

ras Oncogene p21 antigen is present in the most superficial cells of the normal bladder urothelium, as demonstrated by immunohistochemical staining. The pattern and intensity of p21 staining of cells in epithelial hyperplasia and low grade bladder carcinoma were similar to that seen in the normal urothelium. In contrast, epithelial cells in "premalignant" (dysplastic) lesions and high grade carcinomas exhibited an intense staining reaction for p21 antigen. ras p21 may be a useful marker for the malignant potential of both premalignant lesions and carcinomas of the bladder.

Simplified reverse dot blot analyses for detecting ras oncogene mutations

1997 ◽  
Vol 2 (3) ◽  
pp. 169-176 ◽  
Author(s):  
M ALBITAR ◽  
W WU ◽  
E FELTZ ◽  
G JIN ◽  
C HIRSCHGINSBERG ◽  
...  
Keyword(s):  
Ras Oncogene ◽  
Dot Blot ◽  
Reverse Dot Blot
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