Abstract B02: Efficacy of EPA-enriched supplement compared with standard formula on body weight changes in malnourished head and neck cancer patients undergoing surgery: A randomized study

2020 ◽  
Author(s):  
Kitti Jantharapattana ◽  
Orachat Orapipatpong
Keyword(s):  
Body Weight ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Randomized Study ◽  
Weight Changes ◽  
Body Weight Changes ◽  
Standard Formula

scholarly journals Exploration of risk factors for weight loss in head and neck cancer patients

2015 ◽  
Vol 14 (4) ◽  
pp. 343-352 ◽  
Author(s):  
Patrick Dawson ◽  
Amy Taylor ◽  
Chris Bragg
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Weight Loss ◽  
Body Weight ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Linear Regression Analysis ◽  
Relative Significance

AbstractIntroductionHead and neck cancer patients receiving radiotherapy can experience a number of toxicities, including weight loss and malnutrition, which can impact upon the quality of treatment. The purpose of this retrospective cohort study is to evaluate weight loss and identify predictive factors for this patient group.Materials and methodsA total of 40 patients treated with radiotherapy since 2012 at the study centre were selected for analysis. Data were collected from patient records. The association between potential risk factors and weight loss was investigated.ResultsMean weight loss was 5 kg (6%). In all, 24 patients lost >5% starting body weight. Age, T-stage, N-stage, chemotherapy and starting body weight were individually associated with significant differences in weight loss. On multiple linear regression analysis age and nodal status were predictive.ConclusionYounger patients and those with nodal disease were most at risk of weight loss. Other studies have identified the same risk factors along with several other variables. The relative significance of each along with a number of other potential factors is yet to be fully understood. Further research is required to help identify patients most at risk of weight loss; and assess interventions aimed at preventing weight loss and malnutrition.

scholarly journals miRNA-130a Significantly Improves Accuracy of SGA Nutritional Assessment Tool in Prediction of Malnutrition and Cachexia in Radiotherapy-Treated Head and Neck Cancer Patients

Cancers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 294 ◽  
Author(s):  
Tomasz Powrózek ◽  
Radosław Mlak ◽  
Anna Brzozowska ◽  
Marcin Mazurek ◽  
Paweł Gołębiowski ◽  
...  
Keyword(s):  
Body Weight ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Predictive Value ◽  
Assessment Tool ◽  
Nutritional Assessment ◽  
Area Under The Curve ◽  
Body Weight Loss

Background: Investigation of novel cachexia-related markers is one of the major challenges in contemporary oncology. Among studied markers, the miRNA seems to be promising due to its possibility to regulate genes responsible for induction of inflammatory response, muscle atrophy and fat tissue wasting. The aim of the study was to investigate the role of blood-circulating miRNA-130a in prediction of cancer cachexia in 70 head and neck cancer patients (HNC) subjected to radiotherapy. Moreover, diagnostic accuracy of SGA (Subjective Global Assessment) scoring and miRNA-130a level was evaluated in various cachexia models. Results: miRNA-130a level negatively correlated with plasma TNF-α concentration (r = −0.560; p < 0.001). Patients with low miRNA expression had over 3-fold higher risk of body mass index (BMI) decrease below 18.5 after the termination of therapy; over 6-fold higher risk of losing over 5% of body weight and higher risk of >10% weight reduction odds ratio (OR) = 14.18 compared to other cases. ROC analysis performed for miRNA-130a allowed to distinguish cachectic patients (body weight loss >5%) from moderately or mildly malnourished ones with optimal sensitivity of 79.4% and specificity of 80.8% area under the curve (AUC) = 0.865). miRNA significantly improved nutritional assessment conducted using SGA, achieving the following values: sensitivity 88.6%, specificity 94.3%, positive predictive value (PPV) 93.9%, negative predictive value (NPV).89.2%. Conclusion: miRNA-130a demonstrates potential clinical utility in prediction of cachexia prior to the therapy in HNC patients. Simultaneous use of both tools—SGA and miRNA—significantly improved the accuracy in the diagnosis of cachexia.

scholarly journals Oral Nutritional Supplementation Affects the Dietary Intake and Body Weight of Head and Neck Cancer Patients during (Chemo) Radiotherapy

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2516 ◽  
Author(s):  
Isabela Borges Ferreira ◽  
Emanuelle do Nascimento Santos Lima ◽  
Paula Philbert Lajolo Canto ◽  
Cristiana Araújo Gontijo ◽  
Yara Cristina de Paiva Maia ◽  
...  
Keyword(s):  
Body Weight ◽  
Head And Neck Cancer ◽  
Dietary Intake ◽  
Head And Neck ◽  
Neck Cancer ◽  
Treatment Time ◽  
Nutritional Supplementation ◽  
Weight Changes ◽  
Micronutrient Intake ◽  
Calcium Magnesium

Considering the symptoms of (chemo) radiotherapy and the reduction in food intake in head and neck cancer (HNC) patients, this study aimed to investigate the association between treatment time points and oral nutritional supplementation (ONS) on dietary intake to estimate the frequency of energy and nutrient inadequacy, and also to evaluate body weight changes (BWC). Dietary intake data of 65 patients were obtained from 24-h dietary recalls and prevalence of inadequacy was calculated before or at the beginning (T0), in the middle (T1), and at the end of treatment (T2). BWC were calculated as the weight difference considering the previous weight reported and/or measured. Energy and macronutrient intake decreased in T1 and then improved in T2 (p < 0.001 for both). Micronutrient intake increased during treatment due to ONS use, but still presented a high probability of inadequate intake. In particular, calcium, magnesium, and vitamin B6 showed almost 100% of probability of inadequacy for those who did not use ONS. Finally, overweight patients suffered a higher weight accumulated deficit with a delta of −15 kg compared to other BMI (body mass index) categories. Therefore, we strongly recommend initiating nutritional counseling in conjunction with prophylactic ONS prescription from diagnosis to adjust nutrient intake and minimize weight loss.

Cisplatin otoprotection using transtympanic L-N-acetylcysteine: A pilot randomized study in head and neck cancer patients

2013 ◽  
Vol 124 (3) ◽  
pp. E87-E94 ◽  
Author(s):  
John Yoo ◽  
Scott J. Hamilton ◽  
Douglas Angel ◽  
Kevin Fung ◽  
Jason Franklin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Randomized Study
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