SUN-LB324: Body Weight and Hand Grip Strength During Curative Radiotherapy: Is There A Greater Decline In Older Head And Neck Cancer Patients?

2017 ◽  
Vol 36 ◽  
pp. S174
Author(s):  
S. Lichthart ◽  
L. van Miert ◽  
M. Kennis ◽  
E. Leistra ◽  
R. Poorter ◽  
...  
Keyword(s):  
Body Weight ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Grip Strength ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Hand Grip Strength ◽  
Hand Grip ◽  
Curative Radiotherapy

Hand-grip strength does not correlate with treatment-related weight loss in patients with head and neck cancer

2015 ◽  
Vol 129 (7) ◽  
pp. 706-709 ◽  
Author(s):  
B Cosway ◽  
M Easby ◽  
S Covington ◽  
I Bowe ◽  
V Paleri
Keyword(s):  
Head And Neck Cancer ◽  
Nutritional Status ◽  
Head And Neck ◽  
Grip Strength ◽  
Neck Cancer ◽  
Nutritional Assessment ◽  
Hand Grip Strength ◽  
Prospective Audit ◽  
Hand Grip ◽  
Routine Assessment

AbstractBackground:Hand-grip strength has been shown to be a reliable predictor of health outcomes. However, evidence supporting its use as an indicator of nutritional status is inconsistent. This study investigated its use in monitoring nutritional status in patients with head and neck cancer.Methods:A prospective audit of patients treated for head and neck cancer was undertaken at four centres over a three-month period in 2009. Nutritional outcomes were collected at 3, 6 and 12 months, and the data were statistically analysed.Results:Data from 114 patients showed that mean weight, but not hand-grip strength, fell significantly at 3, 6 and 12 months post-treatment (p < 0.003 vs p < 0.126).Conclusion:A fall in weight does not coincide with a drop in hand-grip strength in patients receiving treatment for head and neck cancer. Hand-grip strength may therefore not be of benefit in the nutritional assessment of these patients and should not be part of routine assessment.

scholarly journals Evaluation of the prevalence and severity of xerophthalmia in head and neck cancers patients undergoing curative radiotherapy

2016 ◽  
Vol 14 (4) ◽  
Author(s):  
Sowmya V ◽  
Dipika Jayachander ◽  
Vijna Kamath ◽  
Mithun SK Rao ◽  
Mohammed Raees Tonse ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Keratoconjunctivitis Sicca ◽  
Study Objective ◽  
Cancer Group ◽  
Curative Radiotherapy ◽  
Significant Difference ◽  
Rectal Cancers

  Background: The study objective was to assess the development of xerophthalmia [dry eye syndrome (DES) or keratoconjunctivitis sicca] in head and neck cancer patients undergoing radiotherapy.Methods: Twenty two head and neck cancer patients requiring more than 60 Gy of curative radiotherapy/chemoradiotherapy and ten patients requiring radiotherapy/ chemoradiotherapy for treating cancers in the non head and neck regions (like breast, oesophagus, prostate, cervix and rectal cancers) were also enrolled in the study. The development of DES was studied at the beginning (day 0, before the start of radiotherapy) at day 21 (after completion of 30 Gy) and on completion of the treatment (> 60 Gy). As a comparative cohort, people with non head and neck cancer needing curative radiotherapy were also evaluated for comparison.Results: There was no difference in degree of DES between the Head and Neck cancer cohorts and non head and neck group at the beginning of treatment. However there was a statistically significant difference (p < 0.001) between the two groups at both mid and end of RT time point. Inter comparison between the various time points in the head and neck cancer group showed that the incidence of DES increased with the radiation exposure and was significant (pre to mid p < 0.001; and mid to end p < 0.005). A negative (r = -0.262) correlation was seen between DES and distance.Conclusions: The study showed that lesser the distance from the epicenter of the radiation to the orbital rim more was the severity of DES.

scholarly journals Exploration of risk factors for weight loss in head and neck cancer patients

2015 ◽  
Vol 14 (4) ◽  
pp. 343-352 ◽  
Author(s):  
Patrick Dawson ◽  
Amy Taylor ◽  
Chris Bragg
Keyword(s):  
Risk Factors ◽  
At Risk ◽  
Weight Loss ◽  
Body Weight ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Linear Regression Analysis ◽  
Relative Significance

AbstractIntroductionHead and neck cancer patients receiving radiotherapy can experience a number of toxicities, including weight loss and malnutrition, which can impact upon the quality of treatment. The purpose of this retrospective cohort study is to evaluate weight loss and identify predictive factors for this patient group.Materials and methodsA total of 40 patients treated with radiotherapy since 2012 at the study centre were selected for analysis. Data were collected from patient records. The association between potential risk factors and weight loss was investigated.ResultsMean weight loss was 5 kg (6%). In all, 24 patients lost >5% starting body weight. Age, T-stage, N-stage, chemotherapy and starting body weight were individually associated with significant differences in weight loss. On multiple linear regression analysis age and nodal status were predictive.ConclusionYounger patients and those with nodal disease were most at risk of weight loss. Other studies have identified the same risk factors along with several other variables. The relative significance of each along with a number of other potential factors is yet to be fully understood. Further research is required to help identify patients most at risk of weight loss; and assess interventions aimed at preventing weight loss and malnutrition.

PP075-MON: Echium Oil is not Protective Against Weight Loss in Head and Neck Cancer Patients Undergoing Curative Radiotherapy

2014 ◽  
Vol 33 ◽  
pp. S158
Author(s):  
L. Pottel ◽  
M. Lycke ◽  
T. Boterberg ◽  
H. Pottel ◽  
L. Goethals ◽  
...  
Keyword(s):  
Weight Loss ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Echium Oil ◽  
Curative Radiotherapy

scholarly journals miRNA-130a Significantly Improves Accuracy of SGA Nutritional Assessment Tool in Prediction of Malnutrition and Cachexia in Radiotherapy-Treated Head and Neck Cancer Patients

Cancers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 294 ◽  
Author(s):  
Tomasz Powrózek ◽  
Radosław Mlak ◽  
Anna Brzozowska ◽  
Marcin Mazurek ◽  
Paweł Gołębiowski ◽  
...  
Keyword(s):  
Body Weight ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Predictive Value ◽  
Assessment Tool ◽  
Nutritional Assessment ◽  
Area Under The Curve ◽  
Body Weight Loss

Background: Investigation of novel cachexia-related markers is one of the major challenges in contemporary oncology. Among studied markers, the miRNA seems to be promising due to its possibility to regulate genes responsible for induction of inflammatory response, muscle atrophy and fat tissue wasting. The aim of the study was to investigate the role of blood-circulating miRNA-130a in prediction of cancer cachexia in 70 head and neck cancer patients (HNC) subjected to radiotherapy. Moreover, diagnostic accuracy of SGA (Subjective Global Assessment) scoring and miRNA-130a level was evaluated in various cachexia models. Results: miRNA-130a level negatively correlated with plasma TNF-α concentration (r = −0.560; p < 0.001). Patients with low miRNA expression had over 3-fold higher risk of body mass index (BMI) decrease below 18.5 after the termination of therapy; over 6-fold higher risk of losing over 5% of body weight and higher risk of >10% weight reduction odds ratio (OR) = 14.18 compared to other cases. ROC analysis performed for miRNA-130a allowed to distinguish cachectic patients (body weight loss >5%) from moderately or mildly malnourished ones with optimal sensitivity of 79.4% and specificity of 80.8% area under the curve (AUC) = 0.865). miRNA significantly improved nutritional assessment conducted using SGA, achieving the following values: sensitivity 88.6%, specificity 94.3%, positive predictive value (PPV) 93.9%, negative predictive value (NPV).89.2%. Conclusion: miRNA-130a demonstrates potential clinical utility in prediction of cachexia prior to the therapy in HNC patients. Simultaneous use of both tools—SGA and miRNA—significantly improved the accuracy in the diagnosis of cachexia.

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