Use of Macro- and Micronutrients for Nutrition Support in Inflammatory Bowel Disease

1999 ◽  
pp. 155-170 ◽  
Author(s):  
David H. Alpers
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Nutrition Support ◽  
Inflammatory Bowel ◽  
Macro And Micronutrients

scholarly journals Effect of a Nutrition Support Formula in Adults With Inflammatory Bowel Disease: A Pilot Study

2019 ◽  
Vol 8 ◽  
pp. 216495611986725
Author(s):  
Jennifer J Ryan ◽  
Douglas A Hanes ◽  
Ryan D Bradley ◽  
Nikhat Contractor
Keyword(s):  
Inflammatory Bowel Disease ◽  
Pilot Study ◽  
Blood Cell ◽  
Vitamin B12 ◽  
Bowel Disease ◽  
Inflammatory Markers ◽  
Nutrition Support ◽  
Serum Folate ◽  
Inflammatory Bowel ◽  
Rbc Count

Background Due to the high prevalence of nutrient deficiencies in patients with inflammatory bowel disease (IBD), routine monitoring of nutrient status and supplementation are recommended. Objective This preliminary study was implemented to prospectively identify potential effects of a nutrition support formula on blood nutrient parameters in adults with IBD. Methods Ten adults with Crohn’s disease or ulcerative colitis were recruited from the Portland, Oregon, metropolitan area into a single-arm, open-label pilot study. Participants consumed a nutrition support beverage twice daily for 12 weeks. The formula contained a mixture of micronutrients (including methylated forms of folate and vitamin B12), macronutrients, and phytonutrients (including curcumin, xanthohumol, ginger compounds, and quercetin). Primary measures were the following parameters: folate, vitamin B12, red blood cell (RBC) count, hemoglobin, hematocrit, electrolytes, and albumin. Exploratory measures included a food frequency questionnaire, circulating blood cell counts, and inflammatory markers. Results Nine participants completed the study and one withdrew. Adherence was 98%. Serum folate increased 48.7% ( P = .029), serum vitamin B12 increased 17.4% but did not reach statistical significance ( P = .053), and red cell distribution width (RDW) decreased 9.2% ( P = .012) over the 12-week study period. There were minimal shifts in total white blood cell (WBC) counts (−1.0%, P = .845), but percent neutrophils decreased 10.4% ( P = .042) and absolute lymphocyte count increased 18.6% ( P = .048). RBC count, hemoglobin, hematocrit, electrolytes, albumin, and inflammatory markers did not change significantly. Post hoc analysis demonstrated that neutrophil–lymphocyte ratio (NLR) decreased 18.4% (not significant, P = .061). Conclusion Serum folate and RDW improved in adults with IBD after 12 weeks. Modulation of leukocyte subtypes was also observed, including a decrease in neutrophils and an increase in lymphocytes, with no change in total WBC count. A randomized, controlled study to further examine effects of the nutrition support formula will be initiated to follow up on this promising, but preliminary investigation.

Nutrition support in inflammatory bowel disease

1994 ◽  
Vol 78 (6) ◽  
pp. 1443-1456 ◽  
Author(s):  
James D. Lewis ◽  
Rosemarie L. Fisher
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Nutrition Support ◽  
Inflammatory Bowel

scholarly journals Prevalence of Malnutrition, Its Risk Factors, and the Use of Nutrition Support in Patients with Inflammatory Bowel Disease

2022 ◽  
Author(s):  
Jing Liu ◽  
Xiaolong Ge ◽  
Chunhui Ouyang ◽  
Dongxu Wang ◽  
Xiaoqi Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Severe Disease ◽  
Nutrition Support ◽  
Chinese Patients ◽  
Nutrient Deficiencies ◽  
Cross Sectional ◽  
Essential Components ◽  
Inflammatory Bowel

Abstract Background Malnutrition is prevalent among patients with inflammatory bowel disease (IBD). Nutritional profiles among Asian patients with IBD have seldom been investigated. We assessed the prevalence of and risk factors for malnutrition, use of nutrition support, and sociopsychological status associated with malnutrition among patients with IBD in China. Methods Patients with ulcerative colitis (UC) and Crohn’s disease (CD) recruited from 43 tertiary referral hospitals were screened for malnutrition and nutrient deficiencies in this cross-sectional study. The use of nutrition support was recorded. The sociopsychological status was assessed by subjective questionnaires. Factors associated with malnutrition were analyzed, and multivariate regression was used to determine independent predictors for malnutrition. Results We recruited 1013 patients with a median age of 35.0 years, 58.5% of them had CD, and 61.4% of all patients were male. Overall, 49.5% (501) of patients were diagnosed with malnutrition, including 57.0% of patients with CD, 38.8% of patients with UC, and 44.1% of patients with quiescent or mildly active disease. Nutrient deficiencies were prevalent despite the absence of malnutrition. Malnutrition was associated with adverse sociopsychological status, including decreased social support, higher perceived stress, and impaired quality of life. Moderate to severe disease activity and extensive disease were two independent risk factors for malnutrition. In total, 41.6% of patients received nutrition support, and patients with risk factors were more likely to receive nutrition support. Conclusions Malnutrition was highly prevalent and associated with adverse consequences in Chinese patients with IBD. Malnutrition screening and early initiation of nutrition support are essential components in IBD care.

scholarly journals Enteral Nutrition Support to Treat Malnutrition in Inflammatory Bowel Disease

Nutrients ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 2125-2133 ◽  
Author(s):  
Roberta Altomare ◽  
Giuseppe Damiano ◽  
Alida Abruzzo ◽  
Vincenzo Palumbo ◽  
Giovanni Tomasello ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Enteral Nutrition ◽  
Bowel Disease ◽  
Nutrition Support ◽  
Inflammatory Bowel ◽  
Enteral Nutrition Support

scholarly journals The Effect of Enteral Nutrition Support Rich in TGF-β in the Treatment of Inflammatory Bowel Disease in Childhood

Medicina ◽  
2019 ◽  
Vol 55 (10) ◽  
pp. 620 ◽  
Author(s):  
Mehmet Agin ◽  
Aylin Yucel ◽  
Meltem Gumus ◽  
Hasan Ali Yuksekkaya ◽  
Gokhan Tumgor
Keyword(s):  
Inflammatory Bowel Disease ◽  
Enteral Nutrition ◽  
Bowel Disease ◽  
Clinical Laboratory ◽  
Nutrition Support ◽  
Early Recovery ◽  
The Third ◽  
Laboratory Values ◽  
Inflammatory Bowel ◽  
Enteral Nutrition Support

Background and Objective: Malnutrition is a major complication of inflammatory bowel disease (IBD). Our aim of the study was to examine the effects of Modulen IBD supplementation, which was administered to IBD patients without limiting their daily diet in addition to medical treatment, on the clinical, laboratory, anthropometric values, and disease activities of these patients. Materials and Methods: Seventy three children with IBD were evaluated retrospectively. The cases were classified as those who had Crohn disease receiving (CD-M; n = 16) or not receiving Modulen IBD (CD; n = 19) and those who had ulcerative colitis receiving (UC-M; n = 13) or not receiving Modulen IBD (UC; n = 25). Disease activities, laboratory values, remission rates, and anthropometric measurements of the groups were compared. In addition to IBD treatment, Modulen IBD in which half of the daily calorie requirement was provided was given for eight weeks. Results: In the third month of treatment, 14 (88%) patients were in remission in CD-M group and eight (42%) patients were in remission in CD group. The height and weight z scores, which were low at the time of diagnosis, improved in the first week in CD-M group. Inflammatory parameters (UC) were significantly lower in the UC-M group compared to the UC group in first and third months. In the third month, eight (62%) patients in the UC-M group and four (16%) in the UC group were remitted clinically and in terms of laboratory values. Conclusions: TGF-β-rich enteral nutrition support in children with IBD is an easy, effective, and reliable approach. It was shown that TGF-β-rich enteral nutritional supplementation enabled the disease to enter the remission earlier, and contributed to the early recovery of weight and height scores.

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