Multiple Genes Governing Biological Functions in the Genetic Backgrounds of Laboratory Mice and Asian Wild Mice

1999 ◽  
pp. 1-12 ◽  
Author(s):  
K. Moriwaki ◽  
N. Miyashita ◽  
Y. Yamaguchi ◽  
T. Shiroishi
Keyword(s):  
Laboratory Mice ◽  
Biological Functions ◽  
Wild Mice ◽  
Multiple Genes

scholarly journals Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice

2009 ◽  
Vol 2 (1) ◽  
pp. 11 ◽  
Author(s):  
Ming-Gao Zhao ◽  
Hiroki Toyoda ◽  
Yu-Kun Wang ◽  
Min Zhuo
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Long Term Potentiation ◽  
Anterior Cingulate ◽  
Laboratory Mice ◽  
Wild Mice ◽  
Term Potentiation

scholarly journals Risk Assessment for Use of a Porcine Circovirus-Contaminated Reagent in a Barrier Maintained Rodent Colony

2020 ◽  
Vol 59 (5) ◽  
pp. 575-579
Author(s):  
Norman C Peterson ◽  
Aaron A Berlin
Keyword(s):  
Risk Assessment ◽  
Mouse Model ◽  
Cell Cultures ◽  
Direct Contact ◽  
Model Development ◽  
Porcine Circovirus ◽  
Laboratory Mice ◽  
Wild Mice ◽  
Pancreatic Elastase ◽  
Porcine Pancreatic Elastase

A proposal for the use of porcine pancreatic elastase (PPE) to develop a mouse model of pulmonary emphysema raised concerns about introducing contaminating porcine viruses into our barrier facility. Porcine Circovirus (PCV) is a known contaminant of vaccines and cell cultures that have been exposed to porcine-derived reagents. Endemic infection of PCV3 in laboratory mice has been reported, and some evidence supports natural PCV infection in wild mice. PPE samples from 2 different vendors tested positive for DNA from both PCV2 and 3. To allow model development with these reagents to proceed, we developed a protocol that would meet scientific objectives, minimize exposure of mice, and provide information on the potential for the virus to spread. Five d after BALB/c mice received intralaryngeal administration of PPE, lungs were harvested and analyzed for evidence of disease. Tissues from other major organs were submitted to test for disseminated PCV2 and 3 DNA. Similarly, tissues (including lungs) from direct contact nude sentinel mice were analyzed for the presence of the virus. To evaluate the possibility of endemic PCV2/3 infection, we also surveyed non-porcine reagent exposed mice on other studies. PCV2 and 3 was not detected in any of the tissues submitted. Although this study provided no evidence of infection and transmission of PCV2/3 from the contaminated PPE sample over the 5 d study, further work is needed to understand the risks and impact of introducing PCV contaminated cells or reagents into barrier maintained rodent colonies.

scholarly journals Accounting for phylogenetic relatedness in cross-species analyses of telomere shortening rates

2020 ◽  
Vol 1 ◽  
Author(s):  
Michael Le Pepke ◽  
Dan T.A. Eisenberg
Keyword(s):  
Multivariate Analysis ◽  
Body Mass ◽  
Dna Sequences ◽  
Phylogenetic Signal ◽  
Life History Strategies ◽  
Laboratory Mice ◽  
Telomere Shortening ◽  
Wild Mice ◽  
Phylogenetic Relatedness ◽  
Telomere Dynamics

AbstractTelomeres are repeating DNA sequences found on the ends of chromosomes, which shorten with age and are implicated in senescence. Cross-species analyses of telomere shortening rates (TSR) and telomere lengths are important for understanding mechanisms underlying senescence, lifespan and life-history strategies of different species. Whittemore et al. (2019) generated a new dataset on variation in TSR, lifespan and body mass. In phylogenetically uncorrected analyses they found that TSR negatively correlates with lifespan. We re-ran analyses of their dataset using appropriate phylogenetic corrections. We found a strong phylogenetic signal in the association between TSR and body mass. We were able to corroborate Whittemore et al.’s major findings, including while correcting for body mass in a multivariate analysis. Since laboratory mice have different telomere lengths and potentially different telomere dynamics than wild mice, we removed mice from the analysis, which attenuates most associations.

scholarly journals Thogoto Virus Lacking Interferon-Antagonistic Protein ML Is Strongly Attenuated in Newborn Mx1-Positive but Not Mx1-Negative Mice

2004 ◽  
Vol 78 (20) ◽  
pp. 11422-11424 ◽  
Author(s):  
Andreas Pichlmair ◽  
Johanna Buse ◽  
Stephanie Jennings ◽  
Otto Haller ◽  
Georg Kochs ◽  
...  
Keyword(s):  
Animal Models ◽  
Standard Laboratory ◽  
Laboratory Mice ◽  
Highly Pathogenic ◽  
Wild Mice ◽  
Effector Molecules ◽  
Conventional Animal ◽  
Infected Cells ◽  
Virus Mutant ◽  
Interferon Antagonists

ABSTRACT The Thogoto virus ML protein suppresses interferon synthesis in infected cells. Nevertheless, a virus mutant lacking ML remained highly pathogenic in standard laboratory mice. It was strongly attenuated, however, in mice carrying the interferon-responsive Mx1 gene found in wild mice, demonstrating that enhanced interferon synthesis is protective only if appropriate antiviral effector molecules are present. Our study shows that the virulence-enhancing effects of some viral interferon antagonists may escape detection in conventional animal models.

scholarly journals t-Specific DNA polymorphisms among wild mice from Israel and Spain.

Genetics ◽  
1988 ◽  
Vol 119 (1) ◽  
pp. 157-160
Author(s):  
F Figueroa ◽  
E Neufeld ◽  
U Ritte ◽  
J Klein
Keyword(s):  
Laboratory Mouse ◽  
The Other ◽  
Dna Polymorphisms ◽  
Chromosome 17 ◽  
Mouse Strains ◽  
Laboratory Mice ◽  
Wild Type ◽  
Wild Mice ◽  
T Complex ◽  
Length Polymorphisms

Abstract Lehrach and his coworkers have isolated a series of DNA probes that specifically hybridize with different regions of mouse chromosome 17 within the t complex. The probes display restriction fragment length polymorphisms, RFLPs, which are specific for the t haplotypes in all laboratory mouse strains tested thus far. Some of these probes have been used to test wild mice populations for these t-associated DNA forms. It is demonstrated that populations from Germany, Switzerland, Italy, Greece, Yugoslavia, Australia, Costa Rica, and Venezuela contain chromosomes in which all the tested DNA loci display the t-specific polymorphisms. The frequency of mice carrying these chromosomes is as high as 31%. Wild mice from Israel and Spain, on the other hand, carry chromosomes displaying t-specific DNA forms only at one or two of the probed loci, while the other loci carry the wild-type (+) forms. These chromosomes thus resemble the partial t haplotypes known from the study of laboratory mice. One possible interpretation of these findings is that these DNA polymorphisms contributed to the assembly of the complete t haplotypes and that these haplotypes may have originated in the Middle East.

Polymorphism of T-cell receptor genes among laboratory and wild mice: Diverse origins of laboratory mice

1989 ◽  
Vol 30 (6) ◽  
pp. 405-413 ◽  
Author(s):  
Hiroaki Nobuhara ◽  
Keisuke Kuida ◽  
Makoto Furutani ◽  
Toshihiko Shiroishi ◽  
Kazuo Moriwaki ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Laboratory Mice ◽  
Wild Mice ◽  
T Cell Receptor Genes

Environmentally Induced Analgesia in Wild Mice: Comparison with Laboratory Mice

1988 ◽  
Vol 61 (4) ◽  
pp. 330-332 ◽  
Author(s):  
Przemysław Marek ◽  
Jakub Szacki
Keyword(s):  
Laboratory Mice ◽  
Wild Mice

Cytomegalovirus in Wild Mice

1975 ◽  
Vol 33 ◽  
pp. 338-339
Author(s):  
R. Rongey ◽  
J.E. Officer ◽  
J.D. Estes ◽  
G. Coffey ◽  
M.B. Gardner
Keyword(s):  
Immunosuppressive Treatment ◽  
Laboratory Mice ◽  
Cmv Infection ◽  
Virus Inoculation ◽  
Wild Mice ◽  
Naturally Occurring ◽  
High Prevalence ◽  
High Incidence ◽  
Low Prevalence ◽  
Experimental Virus

The inadvertant dissemination of otherwise latent or chronic herpes virus, especially cytomegalovirus (CMV), is an important consideration in humans given immunosuppressive treatment for renal or cardiac transplantation. It is desirable to have an animal model of chronic CMV infection that does not require experimental virus inoculation. Laboratory mice are unsuitable in this regard since they have a low prevalence (2-3%) of naturally occurring chronic CMV infection. However, chronic CMV infection with shedding of virus in saliva is apparently ubiquitous in wild mice (Mus musculus), suggesting that feral mice might be an appropriate model for studying the effects of immunosuppression upon natural CMV infection. We have found that wild mice immunosuppressed with antithymocytic sera (ATS) show a high incidence of disseminated virulent CMV infection.We confirmed the presence of chronic indolent subclinical CMV infection in high prevalence in healthy wild mice.

High frequency of X-Y chromosome dissociation in primary spermatocytes of F1hybrids between Japanese wild mice (Mus musculus molossinus) and inbred laboratory mice

1981 ◽  
Vol 29 (3) ◽  
pp. 166-175 ◽  
Author(s):  
H.T. Imai ◽  
Y. Matsuda ◽  
T. Shiroishi ◽  
K. Moriwaki
Keyword(s):  
Y Chromosome ◽  
Mus Musculus ◽  
High Frequency ◽  
Laboratory Mice ◽  
Wild Mice

scholarly journals Laboratory mice born to wild mice have natural microbiota and model human immune responses

Science ◽  
2019 ◽  
Vol 365 (6452) ◽  
pp. eaaw4361 ◽  
Author(s):  
Stephan P. Rosshart ◽  
Jasmin Herz ◽  
Brian G. Vassallo ◽  
Ashli Hunter ◽  
Morgan K. Wall ◽  
...  
Keyword(s):  
Immune Responses ◽  
Laboratory Mouse ◽  
Preclinical Studies ◽  
Laboratory Mice ◽  
Wild Mice ◽  
Multiple Organs ◽  
Biological Phenomena ◽  
Bacterial Microbiome ◽  
Human Immune ◽  
Natural Microbiota

Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by divergent microbiota and limited translational research value. To address both shortcomings, we transferred C57BL/6 embryos into wild mice, creating “wildlings.” These mice have a natural microbiota and pathogens at all body sites and the tractable genetics of C57BL/6 mice. The bacterial microbiome, mycobiome, and virome of wildlings affect the immune landscape of multiple organs. Their gut microbiota outcompete laboratory microbiota and demonstrate resilience to environmental challenges. Wildlings, but not conventional laboratory mice, phenocopied human immune responses in two preclinical studies. A combined natural microbiota- and pathogen-based model may enhance the reproducibility of biomedical studies and increase the bench-to-bedside safety and success of immunological studies.

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