Leptin and Body Mass Index in Relation to Endometrial Cancer Risk

2002 ◽  
Vol 46 (3-4) ◽  
pp. 147-151 ◽  
Author(s):  
Eleni Petridou ◽  
Maria Belechri ◽  
Nick Dessypris ◽  
Panagiotis Koukoulomatis ◽  
Emmanuel Diakomanolis ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Endometrial Cancer Risk

scholarly journals Body Mass Index in Early Adulthood and Endometrial Cancer Risk for Mismatch Repair Gene Mutation Carriers

2011 ◽  
Vol 117 (4) ◽  
pp. 899-905 ◽  
Author(s):  
Aung Ko Win ◽  
James G. Dowty ◽  
Yoland C. Antill ◽  
Dallas R. English ◽  
John A. Baron ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Mismatch Repair ◽  
Gene Mutation ◽  
Body Mass ◽  
Early Adulthood ◽  
Mismatch Repair Gene ◽  
Repair Gene ◽  
Endometrial Cancer Risk

scholarly journals Childhood body mass index growth trajectories and endometrial cancer risk

2016 ◽  
Vol 140 (2) ◽  
pp. 310-315 ◽  
Author(s):  
Julie Aarestrup ◽  
Michael Gamborg ◽  
Kate Tilling ◽  
Lian G. Ulrich ◽  
Thorkild I.A. Sørensen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Growth Trajectories ◽  
Endometrial Cancer Risk ◽  
Childhood Body Mass Index

Overweight, Obesity and Endometrial Cancer Risk: Results from a Systematic Review and Meta-Analysis

2014 ◽  
Vol 29 (1) ◽  
pp. e21-e29 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Huaizhen Liu ◽  
Shengjie Yang ◽  
Jinjun Zhang ◽  
Liwei Qian ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Meta Analysis ◽  
Overweight And Obesity ◽  
Age At Menarche ◽  
Published Data ◽  
Endometrial Cancer Risk ◽  
Increased Risk

Aim Findings from recent studies suggest that obesity may be associated with an increased risk of endometrial cancer, but several earlier studies were less conclusive. Here we strive to estimate this relationship in a meta-analysis of published data. Methods We searched Pubmed and Embase for studies on body mass index and the risk of endometrial cancer, published from 1989 to 2011. Data were independently extracted and analyzed using random or fixed effects meta-analysis depending on the degree of heterogeneity. Results Seven cohort studies and 11 case-control studies were included in the meta-analysis. Overall, the conditions of excess body weight ([EBW] defined as body mass index [BMI] ≥25 kg/m2), obesity (BMI ≥30 kg/m2) and overweight (25< BMI <30 kg/m2) were associated with an increased risk of endometrial cancer (relative risk [RR] for EBW=1.62, 95% confidence interval [CI], 1.39-1.89; for obesity RR=2.54, 95% CI, 2.11-3.06; for overweight RR=1.32, 95% CI, 1.16-1.50). Subgroup analyses showed that the positive associations were independent of study design, geographic locations, self-reported BMI, alcohol use, smoking habit, history of diabetes, hormone therapy, age at menarche, age at menopause, parity, and age at first full term pregnancy. However, there was no statistically significant association between EBW and endometrial cancer risk for measured BMI (for EBW RR=1.29, 95% CI, 0.66-2.53). Conclusions The findings from this meta-analysis strongly support that the conditions of EBW, overweight, and obesity are all associated with an increased risk of endometrial cancer. Also, the strength of the association increases with increasing BMI.

scholarly journals Body Mass Index, Hormone Replacement Therapy, and Endometrial Cancer Risk: A Meta-Analysis

2010 ◽  
Vol 19 (12) ◽  
pp. 3119-3130 ◽  
Author(s):  
Emma J. Crosbie ◽  
Marcel Zwahlen ◽  
Henry C. Kitchener ◽  
Matthias Egger ◽  
Andrew G. Renehan
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Hormone Replacement Therapy ◽  
Cancer Risk ◽  
Replacement Therapy ◽  
Body Mass ◽  
Meta Analysis ◽  
Hormone Replacement ◽  
Endometrial Cancer Risk

Abstract 14: Body mass index and type 2 diabetes genetic risk scores and endometrial cancer risk among women of European ancestry.

2012 ◽  
Vol 21 (11 Supplement) ◽  
pp. 14-14
Author(s):  
Jennifer Prescott ◽  
Veronica W. Setiawan ◽  
Nicolas Wentzensen ◽  
Fredrick Schumacher ◽  
Herbert Yu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Genetic Risk ◽  
European Ancestry ◽  
Risk Scores ◽  
Endometrial Cancer Risk

scholarly journals Body Mass Index Genetic Risk Score and Endometrial Cancer Risk

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0143256 ◽  
Author(s):  
Jennifer Prescott ◽  
Veronica W. Setiawan ◽  
Nicolas Wentzensen ◽  
Fredrick Schumacher ◽  
Herbert Yu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Endometrial Cancer Risk

Polymorphisms in Base Excision Repair Genes Are Associated With Endometrial Cancer Risk Among Postmenopausal Japanese Women

2013 ◽  
Vol 23 (9) ◽  
pp. 1561-1568 ◽  
Author(s):  
Satoyo Hosono ◽  
Keitaro Matsuo ◽  
Hidemi Ito ◽  
Isao Oze ◽  
Kaoru Hirose ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Body Mass ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Japanese Women ◽  
Cancer Center ◽  
Endometrial Cancer Risk ◽  
Base Excision

ObjectivesPolymorphisms in base excision repair (BER) genes are associated with risk for several types of cancers but have not been studied with respect to endometrial cancer among Japanese women. Therefore, we conducted a case-control study to explore the association between polymorphisms in BER genes and the risk for endometrial cancer.Methods/MaterialsThis study included a total of 91 postmenopausal subjects with endometrial cancer and 261 controls without cancer who visited the Aichi Cancer Center between 2001 and 2005. We focused on single nucleotide polymorphisms within coding regions of 5 BER genes (OGG1,MUTYH,XRCC1,APEX1, andPARP1). To assess lifestyle in the etiology of endometrial cancer, we used a self-administered questionnaire. Associations were evaluated using multivariate unconditional logistic regression models. We also assessed whether there were intergenic associations or an interaction with obesity.ResultsWe observed a significant association between endometrial cancer risk andXRCC1rs1799782 (C > T, Arg194Trp) andXRCC1rs25487 (G > A, Arg399Gln). We uncovered a significant association between obesity (body mass index, ≥25) and rs25487. TheXRCC1polymorphisms were in complete linkage disequilibrium, and theXRCC1haplotype TG associated significantly with endometrial cancer risk. The interaction between the CA haplotype and body mass index was marginally significant, whereas interaction between haplotype inXRCC1and rs1136410 (PARP1) was not significant.ConclusionsWe found a significant association between endometrial cancer risk andXRCC1polymorphisms and haplotype TG in postmenopausal Japanese women.

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