Abstract 14: Body mass index and type 2 diabetes genetic risk scores and endometrial cancer risk among women of European ancestry.

Background: Maternal cardiovascular risk factors have been associated with adverse maternal and fetal outcomes. Given the difficulty in establishing causal relationships using epidemiological data, we applied Mendelian randomization to explore the role of cardiovascular risk factors on risk of developing preeclampsia or eclampsia, and low fetal birthweight. Methods: Uncorrelated single-nucleotide polymorphisms associated systolic blood pressure (SBP), body mass index, type 2 diabetes, LDL (low-density lipoprotein) with cholesterol, smoking, urinary albumin-to-creatinine ratio, and estimated glomerular filtration rate at genome-wide significance in studies of 298 957 to 1 201 909 European ancestry participants were selected as instrumental variables. A 2-sample Mendelian randomization study was performed with primary outcome of preeclampsia or eclampsia (PET). Risk factors associated with PET were further investigated for their association with low birthweight. Results: Higher genetically predicted SBP was associated increased risk of PET (odds ratio [OR] per 1-SD SBP increase 1.90 [95% CI=1.45–2.49]; P =3.23×10 −6 ) and reduced birthweight (OR=0.83 [95% CI=0.79–0.86]; P =3.96×10 −18 ), and this was not mediated by PET. Body mass index and type 2 diabetes were also associated with PET (respectively, OR per 1-SD body mass index increase =1.67 [95% CI=1.44–1.94]; P =7.45×10 −12 ; and OR per logOR increase type 2 diabetes =1.11 [95% CI=1.04–1.19]; P =1.19×10 −3 ), but not with reduced birthweight. Conclusions: Our results provide evidence for causal effects of SBP, body mass index, and type 2 diabetes on PET and identify that SBP is associated with reduced birthweight independently of PET. The results provide insight into the pathophysiological basis of PET and identify hypertension as a potentially modifiable risk factor amenable to therapeutic intervention.

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Metformin and endometrial cancer risk in Chinese women with type 2 diabetes mellitus in Taiwan

Gynecologic Oncology ◽

10.1016/j.ygyno.2015.03.059 ◽

2015 ◽

Vol 138 (1) ◽

pp. 147-153 ◽

Cited By ~ 36

Author(s):

Chin-Hsiao Tseng

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Endometrial Cancer ◽

Cancer Risk ◽

Chinese Women ◽

Endometrial Cancer Risk

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Overweight, Obesity and Endometrial Cancer Risk: Results from a Systematic Review and Meta-Analysis

The International Journal of Biological Markers ◽

10.5301/jbm.5000047 ◽

2014 ◽

Vol 29 (1) ◽

pp. e21-e29 ◽

Cited By ~ 54

Author(s):

Yuanyuan Zhang ◽

Huaizhen Liu ◽

Shengjie Yang ◽

Jinjun Zhang ◽

Liwei Qian ◽

...

Keyword(s):

Body Mass Index ◽

Endometrial Cancer ◽

Cancer Risk ◽

Body Mass ◽

Meta Analysis ◽

Overweight And Obesity ◽

Age At Menarche ◽

Published Data ◽

Endometrial Cancer Risk ◽

Increased Risk

Aim Findings from recent studies suggest that obesity may be associated with an increased risk of endometrial cancer, but several earlier studies were less conclusive. Here we strive to estimate this relationship in a meta-analysis of published data. Methods We searched Pubmed and Embase for studies on body mass index and the risk of endometrial cancer, published from 1989 to 2011. Data were independently extracted and analyzed using random or fixed effects meta-analysis depending on the degree of heterogeneity. Results Seven cohort studies and 11 case-control studies were included in the meta-analysis. Overall, the conditions of excess body weight ([EBW] defined as body mass index [BMI] ≥25 kg/m2), obesity (BMI ≥30 kg/m2) and overweight (25< BMI <30 kg/m2) were associated with an increased risk of endometrial cancer (relative risk [RR] for EBW=1.62, 95% confidence interval [CI], 1.39-1.89; for obesity RR=2.54, 95% CI, 2.11-3.06; for overweight RR=1.32, 95% CI, 1.16-1.50). Subgroup analyses showed that the positive associations were independent of study design, geographic locations, self-reported BMI, alcohol use, smoking habit, history of diabetes, hormone therapy, age at menarche, age at menopause, parity, and age at first full term pregnancy. However, there was no statistically significant association between EBW and endometrial cancer risk for measured BMI (for EBW RR=1.29, 95% CI, 0.66-2.53). Conclusions The findings from this meta-analysis strongly support that the conditions of EBW, overweight, and obesity are all associated with an increased risk of endometrial cancer. Also, the strength of the association increases with increasing BMI.

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Body mass index and obesity-related cancer risk in men and women with type 2 diabetes (ZODIAC-56)

Maturitas ◽

10.1016/j.maturitas.2017.03.322 ◽

2017 ◽

Vol 100 ◽

pp. 200

Author(s):

Steven H. Hendriks ◽

D. Schrijnders ◽

Kjj van Hateren ◽

Kh Groenier ◽

S. Siesling ◽

...

Keyword(s):

Type 2 Diabetes ◽

Body Mass Index ◽

Cancer Risk ◽

Body Mass ◽

Men And Women

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Body mass index and cancer risk in patients with type 2 diabetes: a dose–response meta-analysis of cohort studies

Scientific Reports ◽

10.1038/s41598-021-81671-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Sepideh Soltani ◽

Shima Abdollahi ◽

Dagfinn Aune ◽

Ahmad Jayedi

Keyword(s):

Breast Cancer ◽

Type 2 Diabetes ◽

Body Mass Index ◽

Cancer Risk ◽

Cohort Studies ◽

Body Mass ◽

Dose Response ◽

Meta Analysis ◽

Total Cancer

AbstractAlthough obesity has been associated with an increased cancer risk in the general population, the association in patients with type 2 diabetes (T2D) remains controversial. We conducted a dose–response meta-analysis of cohort studies of body mass index (BMI) and the risk of total and site-specific cancers in patients with T2D. A systematic literature search was conducted in PubMed, Scopus, and Medline until September 2020 for cohort studies on the association between BMI and cancer risk in patients with T2D. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random effects models. Ten prospective and three retrospective cohort studies (3,345,031 participants and 37,412 cases) were included in the meta-analysis. Each 5-unit increase in BMI (kg/m2) was associated with a 6% higher risk of total cancer (RR: 1.06, 95% CI 1.01, 1.10; I2 = 55.4%, n = 6), and with a 12% increased risk in the analysis of breast cancer (RR: 1.12, 95% CI 1.05, 1.20; I2 = 0%, n = 3). The pooled RRs showed no association with prostate cancer (RR: 1.02, 95% CI 0.92, 1.13; I2 = 64.6%, n = 4), pancreatic cancer (RR: 0.97, 95% CI 0.84, 1.11; I2 = 71%, n = 3), and colorectal cancer (RR: 1.05, 95% CI 0.98, 1.13; I2 = 65.9%, n = 2). There was no indication of nonlinearity for total cancer (Pnon-linearity = 0.99), however, there was evidence of a nonlinear association between BMI and breast cancer (Pnon-linearity = 0.004) with steeper increases in risk from a BMI around 35 and above respectively. Higher BMI was associated with a higher risk of total, and breast cancer but not with risk of other cancers, in patients with T2D, however, further studies are needed before firm conclusions can be drawn.

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