Progression of a General Substance Use Pattern among Adolescents in Switzerland? Investigating the Relationship between Alcohol, Tobacco, and Cannabis Use over a 12-Year Period

2004 ◽  
Vol 10 (3) ◽  
pp. 118-125 ◽  
Author(s):  
Emmanuel N. Kuntsche
2019 ◽  
Vol 8 (7) ◽  
pp. 1058 ◽  
Author(s):  
Albert Batalla ◽  
Hella Janssen ◽  
Shiral S. Gangadin ◽  
Matthijs G. Bossong

The endogenous cannabinoid (eCB) system plays an important role in the pathophysiology of both psychotic disorders and substance use disorders (SUDs). The non-psychoactive cannabinoid compound, cannabidiol (CBD) is a highly promising tool in the treatment of both disorders. Here we review human clinical studies that investigated the efficacy of CBD treatment for schizophrenia, substance use disorders, and their comorbidity. In particular, we examined possible profiles of patients who may benefit the most from CBD treatment. CBD, either as monotherapy or added to regular antipsychotic medication, improved symptoms in patients with schizophrenia, with particularly promising effects in the early stages of illness. A potential biomarker is the level of anandamide in blood. CBD and THC mixtures showed positive effects in reducing short-term withdrawal and craving in cannabis use disorders. Studies on schizophrenia and comorbid substance use are lacking. Future studies should focus on the effects of CBD on psychotic disorders in different stages of illness, together with the effects on comorbid substance use. These studies should use standardized measures to assess cannabis use. In addition, future efforts should be taken to study the relationship between the eCB system, GABA/glutamate, and the immune system to reveal the underlying neurobiology of the effects of CBD.


2001 ◽  
Vol 64 (3) ◽  
pp. 319-327 ◽  
Author(s):  
Louisa Degenhardt ◽  
Wayne Hall ◽  
Michael Lynskey

Author(s):  
Jason Isaacs ◽  
Sean MacKinnon ◽  
Kayla Joyce ◽  
Sherry Stewart

BACKGROUND: Daily diary measurements are a common way to assess substance use behaviours, however researchers and clinicians are often cognizant of assessment reactivity (or “reactivity”) in daily substance use measurement. Reactivity involves changes to behaviours that result simply from self-monitoring those behaviours. When reactivity to substance use measurement has been found to exist, it has been identified both as a possible confound in daily diary research and a potential intervention tool in clinical practice. Reactivity to daily self-monitoring of alcohol and tobacco use has been investigated in prior research, however this research has been inconsistent. Reactivity to daily self-monitoring of cannabis use quantity has yet to be documented at all. METHOD: The current study involved secondary analyses of data from N=88 women who self-monitored their cannabis use for 32 consecutive days (Joyce et al., under review). We examined objective reactivity of cannabis use to daily self-monitoring both for the probability of use each day as well as the quantity of cannabis used on each cannabis-using day. At study completion, participants were asked the degree to which they felt self-monitoring impacted their cannabis use (i.e., subjective reactivity). We explored the reported degree of subjective reactivity, and we examined correspondence between objective and subjective reactivity. RESULTS: Hurdle models were the best fit for the data. Participants’ probability of daily cannabis use and the quantity of cannabis use did not change significantly over the study period. For subjective reactivity, many respondents (45%) reported no subjective reactivity, though a majority (55%) reported some degree of subjective reactivity with 24% reporting moderate or more reactivity. A three-step hierarchical linear model was used to investigate the relationship between objective and subjective reactivity. Time was the only predictor in the first step, subjective reactivity was added as a predictor in the second step, and the time x subjective reactivity interaction was explored in the final step. Subjective reactivity was not found to moderate the relationship between time and cannabis use, although there was a significant relationship between self-reported subjective reactivity and variability of cannabis use across the data collection period. CONCLUSIONS: This study determined that participants who report greater subjective reactivity to cannabis measurement are more likely to demonstrate variability in their cannabis usage. While this study did not find a significant change in cannabis scores over time because of reactivity, the non-significant results are valuable from both a research and a clinical standpoint. For research, the lack of change is an indicator that reactivity is likely not a confounding factor in studies involving cannabis daily diary research. From a clinical perspective, the non-significant change indicates that simply self-monitoring cannabis is unlikely to provide standalone benefits when daily self-monitoring is used in clinical practice. It is relevant to note that our study involved a non-help-seeking sample, and future research could benefit from determining whether cannabis reactivity may be moderated by help-seeking behaviours or motivations to change.


2003 ◽  
Vol 182 (6) ◽  
pp. 509-517 ◽  
Author(s):  
A. Boys ◽  
M. Farrell ◽  
C. Taylor ◽  
J. Marsden ◽  
R. Goodman ◽  
...  

BackgroundPsychoactive substance use is strongly associated with psychiatric morbidity in both adults and adolescents.AimsTo determine which of alcohol, nicotine and cannabis is most closely linked to psychiatric disorders in early adolescence.MethodData from 2624 adolescents aged 13–15 years were drawn from a national mental health survey of children. The relationship between psychiatric morbidity and smoking, drinking and cannabis use was examined by logistic regression analyses.ResultsHaving a psychiatric disorder was associated with an increased risk of substance use. Greater involvement with any one substance increased the risk of other substance use. Analyses of the interactions between smoking, drinking and cannabis use indicated that the relationship between substance use and psychiatric morbidity was primarily explained by regular smoking and (to a lesser extent) regular cannabis use.ConclusionsIn this sample, links between substance use and psychiatric disorders were primarily accounted for by smoking. The strong relationship is likely to be due to a combination of underlying individual constitutional factors and drug-specific effects resulting from consumption over the period of adolescent development and growth.


2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M El Ghardallou ◽  
J Sahli ◽  
M Mellouli ◽  
M Limam ◽  
C Zedini ◽  
...  

Abstract Background Experimentation with substance use is common during adolescence. Substance use may result in many health-related problems and contribute to adolescent suicidal behavior. We conducted this study to examine the relationship between substance use and suicidal ideation. Methods This is a cross sectional study conducted among a representative sample of 2020 adolescents enrolled in Tunisian secondary schools using a self-administered questionnaire. Results The prevalence of tobacco, alcohol and cannabis use was respectively 3.7% (95% CI [2.87%-4.52%]), 4.4% (95% CI [3.5%-5.29%]) and 0.8% (95% CI [0.40%-1.18%]) Overall, 17.0% (95% CI [15.3%-18.6%]) reported having suicide ideation during the past 12 months. Tobacco (Odds Ratio = 2.61; 95% CI = 1.59–4.29), alcohol (Odds Ratio = 2.77; 95% CI = 1.76–4.36), and cannabis use (Odds Ratio = 4.98; 95% CI = 1.85–13.96) were significantly associated with suicidal thoughts among adolescents (p < 10-3). Conclusions This cross study has shown a significant association between substance use and suicidal ideation. This relationship can be bidirectional and suicidal ideation and substance use may affect each other. Key messages In his study, the prevalence of substance use was relatively low and was associated with suicidal ideations. The reciprocal link between the two problems and their co-occurrence should be taken into account when planning preventive substance use and suicide programs.


2020 ◽  
Author(s):  
Christopher Greenwood ◽  
George Joseph Youssef ◽  
Primrose Letcher ◽  
Elizabeth Spry ◽  
Lauryn Hagg ◽  
...  

Aims: To explore the process of applying counterfactual thinking in examining causal predictors of substance use trajectories in observational cohort data. Specifically, we examine the extent to which quality of the parent-adolescent relationship and affiliations with deviant peers are causally related to trajectories of alcohol, tobacco, and cannabis use across adolescence and into young adulthood. Methods: Data were drawn from the Australian Temperament Project, a population-based cohort study that has followed a sample of young Australians from infancy to adulthood since 1983. Parent-adolescent relationship quality and deviant peer affiliations were assessed at age 13-14 years. Latent curve models were fitted for past month alcohol, tobacco, and cannabis use (n = 1,590) from age 15-16 to 27-28 years (5 waves). Confounding factors were selected in line with the counterfactual framework. Results: Following confounder adjustment, higher quality parent-adolescent relationships were associated with lower baseline cannabis use, but not alcohol or tobacco use trajectories. In contrast, affiliations with deviant peers were associated with higher baseline binge drinking, tobacco, and cannabis use, and an earlier peak in the cannabis use trajectory. Conclusions: Confounding adjustments weakened several estimated associations and the interpretation of such associations as causal is not without limitations. Nevertheless, findings suggested causal effects of both parent-adolescent relationships and deviant peer affiliations on the trajectory of substance use. Causal effects were however more pervasive (i.e., more substance types) and protracted for deviant peer affiliations. The current study encourages the exploration of causal relationships in observational cohort data, when relevant limitations are transparently acknowledged.


Author(s):  
N.M. Gamage ◽  
C. Darker ◽  
B.P. Smyth

Objectives: Adolescents with substance use disorders (SUDs) exhibit high rates of comorbid psychological problems. This study aimed to examine the impact of an outpatient substance use treatment programme upon the psychological wellbeing of adolescents. Methods: A prospective study was carried out examining psychological symptoms in a group of adolescents attending the Youth Drug and Alcohol (YoDA) Addiction Service in Dublin. Participants were treated with evidenced based psychological models such as cognitive behavioural therapy, motivational interviewing and systemic family therapy. The Becks Youth Inventory was utilised to assess psychological symptoms at treatment entry and repeated three months later at follow up. Results: Among 36 adolescents who were included in this study, poly-substance misuse was the norm. Almost three-quarter had a cannabis use disorder (CUD). There were significant reductions in mean subscale scores of depression (56.0 to 50.8, p = 0.003), anger (55.2 to 49.5, p < 0.001) and disruptive behaviour (61.6 to 56.5, p = 0.002) at follow up. Although there wasn’t a statistically significant reduction in mean scores for anxiety, we observed a significant proportion of participants (p = 0.008) improving and moving out of a moderate to severe symptom range when examined by category. This was also the case for self-concept (p = 0.04). Furthermore this study revealed a positive correlation between the reduction in days of cannabis use and reduction in depressive scores (Pearson correlation 0.49, p = 0.01) among those with a CUD. Conclusion: The findings indicate that substance use treatment for adolescents is associated with important psychological and behavioural improvements.


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