Innervation Zones of the External Anal Sphincter in Healthy Male and Female Subjects

A incontinência fecal em cães e gatos é uma situação na qual o proprietário tem dificuldades para resolver as conseqüências advindas desta lesão, e geralmente os pacientes são submetidos à eutanásia. Algumas técnicas cirúrgicas empregadas na esfincteroplastia são passíveis de complicações como estenose anal ou incontinência fecal. Este experimento teve como objetivo reconstituir o músculo esfíncter anal externo em cães, após iatrogenização da incontinência fecal. Foram utilizados 10 cães hígidos, machos, sem raça definida, com peso variando entre 9 a14 kg. Após incisão de pele circundando a abertura anal, procedeu-se a miectomia bilateral de esfíncter anal externo, iatrogenizando-se a incontinência fecal, a qual foi diagnosticada por meio de avaliação física diária. Trinta dias após, os pacientes foram novamente preparados para cirurgia asséptica e submetidos à esfincteroplastia anal externa com o uso de Fascia lata autológa medindo 8 cm de comprimento e 0,5 cm de largura, em média. Os dez cães incontinentes, em decorrência da miectomia do esfíncter anal externo, apresentaram controle da emissão de fezes em 10 dias após a realização da esfincteroplastia e mantiveram-se assim durante os dois meses de observação póscirúrgica. Dessa maneira concluiu-se que a mioplastia do esfíncter anal externo com Fascia lata autóloga, representa um procedimento eficaz de simples e rápida aplicação, podendo ser utilizado rotineiramente para restabelecer a continência fecal em cães. Experimental myoplasty of the external anal sphincter with autologous Fascia lata in dogs Abstract Fecal incontinence in dogs and cats is a hard condition for owners to solve the consequences of this lesion, being patients usually subjected to euthanasia. Some surgical techniques used in sphincteroplasty are prone to complications such as anal stenosis or fecal incontinence. This experiment objectified to reconstruct the external anal sphincter in dogs after iatrogeny of the fecal incontinence. Ten healthy male dogs of undefined breed, weight ranging from 9 to 14 kg, were used. After dermal incision surrounding the anal opening, bilateral myectomy of the external anal sphincter was performer, with iatrogeny of fecal incontinence, diagnosed by daily physical evaluation. Thirty days later, patients were again prepared for aseptic surgery and went under external anal sphincteroplasty using autologous Fascia lata averaging 8 cm long and 0,5 cm wide. Ten incontinent dogs, due to external anal sphincter myectomy, presented fecal control in ten days after surgery and for the two subsequent months of follow-up. In conclusion, myoplasty of external anal sphincter using autologous Fascia lata is a simple and effective treatment that can be used in fecal incontinence in dogs.

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Ipragliflozin Does Not Prolong QTc Interval in Healthy Male and Female Subjects: A Phase I Study

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.06.009 ◽

2013 ◽

Vol 35 (8) ◽

pp. 1150-1161.e3 ◽

Cited By ~ 7

Author(s):

Wenhui Zhang ◽

Ronald Smulders ◽

Anura Abeyratne ◽

Albert Dietz ◽

Walter Krauwinkel ◽

...

Keyword(s):

Phase I ◽

Phase I Study ◽

Qtc Interval ◽

Healthy Male ◽

Male And Female ◽

Female Subjects

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Single Ascending Dose of ASP3772 Study in Japanese Healthy Male and Female Adults, and Single Ascending Dose Study of ASP3772 in Comparison With PPSV23 in Japanese Elderly Male and Female Subjects

Case Medical Research ◽

10.31525/ct1-nct04265911 ◽

2020 ◽

Author(s):

Keyword(s):

Healthy Male ◽

Elderly Male ◽

Male And Female ◽

Dose Study ◽

Japanese Elderly ◽

Single Ascending Dose Study ◽

Female Subjects

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A single arm, exploratory and pilot study to evaluate the efficacy of a multi-component water-based herbal supplement in hair growth, density, follicle strength and hair fall in healthy male and female subjects

IP Indian Journal of Clinical and Experimental Dermatology ◽

10.18231/j.ijced.2021.047 ◽

2021 ◽

Vol 7 (3) ◽

pp. 249-255

Author(s):

C.S Janaki ◽

Mukta Sachdev ◽

Ritambhara

Keyword(s):

Hair Growth ◽

Inflammatory Factors ◽

Herbal Supplement ◽

Healthy Male ◽

Open Label ◽

Entire Study ◽

Male And Female ◽

Regular Consumption ◽

Study Population ◽

Female Subjects

Most available therapeutics to address alopecia are based on singular targets and mechanism of action based on the assumption of sub-classification to reflect morphological or etiological sub-classes such as hereditary vs acquired factors, anti-inflammatory vs. non-inflammatory factors or scarring vs. non-scarring factors. Impact of oral consumption of Diabliss Hair Water, a multi-component herbal water supplement (HWS) on hair fall reduction, hair growth, hair density, hair thickness was investigated in a single arm, exploratory, pilot open label clinical study among healthy male and female subjects of age group between 35-50 years, with hair fall and hair thinning concerns. The study was conducted under dermatological control and included hair fall by comb test, hair pull test, hair thinning measurement using photo numerical scale (modified Norwood and Ludwig scale) and assessment for hair quality along with the phototrichogram assessment using Trichoscan® with Cutiscope. The Diabliss HWS was efficacious in improving hair growth rate and density as per TrichoScan® assessment, improvement in hair thickness as per Caslite-Nova software. The Diabliss HWS was also efficacious in improving the hair tensile strength (break force by Chatillon Force gauge), reducing hair fall and improving the hair quality. By the end of the study the Diabliss HWS was found to show an improvement in the entire study population in all of the assessments parameters. Dermatologist assessment parameters of hair texture and hair shine also showed improvements in the entire study population. The Diabliss HWS was found to be efficacious in providing hair fall control and hair growth benefits as per the dermatological and instrumental evaluations using TrichoScan®. The product was well tolerated with no product related AE or SAE with regular consumption for 06 months.

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The Gender Effects of Heart Rate Variability Response during Short-Term Exercise using Stair Stepper from Statistical Analysis

Indonesian Journal of Electrical Engineering and Computer Science ◽

10.11591/ijeecs.v2.i2.pp359-366 ◽

2016 ◽

Vol 2 (2) ◽

pp. 359 ◽

Cited By ~ 1

Author(s):

Nor Aziyatul Izni Mohd Rosli ◽

Mohd Azizi Abdul Rahman ◽

Malarvili Balakrishnan ◽

Takashi Komeda ◽

Saiful Amri Mazlan ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Nervous System ◽

Gender Effects ◽

P Value ◽

Healthy Male ◽

Short Term ◽

Male And Female ◽

Males And Females ◽

Female Subjects

This study is aimed to explore the Heart Rate Variability (HRV) response during short-term exercise by stair stepper and to compare the finding between young healthy male and female subjects. The responses were statistically analyzed by applying independent-samples t-test statistical method. The calculation of Coefficient of Variation (CoV (%)) and the slope of the linear regression is used to assess the steadiness of the HRV. Furthermore, the results also demonstrated that female subjects had greater significant p-value of RMSSD feature and significance p-value in a LF feature is greater in male. Thus, the ongoing results demonstrated that males have the sympathetic drive and females have predominant parasympathetic drive using short-term exercise by stepper. Thus, the experiment results indicate the suitability of developing rehabilitation devices in the field of Autonomic Nervous System (ANS), research, control system and rehabilitation enginering, which may help to isolate males and females.

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A Study of Antithrombin III Levels in Healthy Male and Female Subjects Tested Monthly for Eleven Months by Four Methods

10.1055/s-0039-1680741 ◽

1977 ◽

Author(s):

M.S. Sirridge ◽

R. Shannon

Keyword(s):

Standard Deviation ◽

Functional Activity ◽

Antithrombin Iii ◽

Normal Subjects ◽

Healthy Male ◽

Male And Female ◽

Serum Pool ◽

Coefficients Of Variation ◽

Activity Method ◽

Female Subjects

Because of the increased interest in the role of Antithrombin III as a physiologic coagulation inhibitor and because of some previous problems we encountered in sequential measurement of this protein, the present study was designed to answer 3 questions: 1) Which of four methods (2 functional activity methods and 2 immunologic methods) is the most practical, accurate and reproducible? 2) Do normal subjects have relatively constant levels when tested sequentially by these methods? 3) What is the range of Antithrombin III levels in young healthy male and female subjects? A serum pool was tested by each of the 3 serum methods at least 20 different times throughout the study. The von Kaulla functional activity method gave the lowest standard deviation and coefficient of variation. In the group of 29 subjects this method proved to be the most practical and also gave very low coefficients of variation for individual subjects when they were tested from 11 to 16 times (range .023-.054). The other methods did not give such low coefficients of variation for individual subjects. The range of levels was 77 to 110% on 344 samples tested by the von Kaulla method With a mean of 92.8% and a standard deviation of 6.4%. The standard deviations for the pool and for individual subjects were greater but quite satisfactory for all methods.

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