Morphological Findings in Infants and Placentas of Diabetic Mothers

Author(s):  
Marina Kos ◽  
Martin Vogel
1971 ◽  
Vol 25 (02) ◽  
pp. 354-378 ◽  
Author(s):  
R Gottlob ◽  
L Stockinger ◽  
U Pötting ◽  
G Schattenmann

SummaryIn vitro whole blood clots of various ages, experimental thrombi produced in the jugular vein of rabbits and human thrombi from arteries and veins were examined in semi-thin sections and by means of electron microscopy.In all types of clots examined a typical course of retraction was found. Retraction starts with a dense excentrical focus which grows into a densification ring. After 24 hours the entire clot becomes almost homogeneously dense; later a secondary swelling sets in.Shortly after coagulation the erythrocytes on the rim of the clot are bi-concave discs. They then assume the shape of crenate spheres, turn into smooth spheres and finally become indented ghosts which have lost the largest part of their contents. In the inner zone, which makes up the bulk of the clot, we observed bi-concave discs prior to retraction. After retraction we see no crenations but irregularly shaped erythrocytes. Once the secondary swelling sets in, the cross-section becomes polygonal and later spherical. After extensive hemolysis we observe the “retiform thrombus” made up of ghosts.Experimental and clinical thrombi present the same morphology but are differentiated from in vitro clots by: earlier hemolysis, immigration of leukocytes, formation of a rim layer consisting of fibrin and thrombocytes, and the symptoms of organization. Such symptoms of organization which definitely will prevent lysis with streptokinase were found relatively late in experimental and clinical thrombi. Capillary buds and capillary loops were never found in clinical thrombi prior to the third month.The morphological findings agree with earlier physical and enzymatic investigations. The observation that phenomena of reorganization occur relatively late and frequently only in the rim areas of large thrombi explains why lytic therapy is possible in some of the chronic obliterations.


1961 ◽  
Vol 37 (3) ◽  
pp. 441-444
Author(s):  
A. Nygaard ◽  
M. Felbo ◽  
J. Pedersen

ABSTRACT In a study of 173 pregnancies in 130 diabetic mothers of White's groups B, C and D who had received long-term treatment during pregnancy, the authors found cases of diabetes – in addition to the mother – in the maternal family, in the father and his family, or in the maternal as well as paternal family in a total of 100 pregnancies (57 %). The perinatal mortality was only slightly – and not significantly – higher among infants whose families included other diabetics than the mother. This higher mortality was found only among male infants of whom there was a preponderance in pregnancies with familial diabetes, but this was also not statistically significant. Thus, the result indirectly indicates that the primary cause of the high mortality among the infants of diabetic women must be the fact that the foetus develops in a diabetic environment.


2018 ◽  
Author(s):  
Heather Stirling ◽  
Sana Ali ◽  
Mariyah Selmi ◽  
Anuja Joshi ◽  
Emma Helm ◽  
...  

Diabetes ◽  
1979 ◽  
Vol 28 (7) ◽  
pp. 697-699 ◽  
Author(s):  
J. B. Young ◽  
W. R. Cohen ◽  
E. B. Rappaport ◽  
L. Landsberg

Diabetes ◽  
1981 ◽  
Vol 30 (4) ◽  
pp. 271-274 ◽  
Author(s):  
R. D. Milner ◽  
P. K. Wirdnam ◽  
J. Tsanakas

Diabetes ◽  
1991 ◽  
Vol 40 (12) ◽  
pp. 1679-1684 ◽  
Author(s):  
J. H. Warram ◽  
B. C. Martin ◽  
A. S. Krolewski

Diabetes ◽  
1988 ◽  
Vol 37 (10) ◽  
pp. 1328-1334 ◽  
Author(s):  
J. H. Warram ◽  
A. S. Krolewski ◽  
C. R. Kahn

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. 37-41 ◽  
Author(s):  
T Yu Pestrikova ◽  
E A Yurasova ◽  
I V Yurasov

Issues of treatment and rehabilitation patients with pelvic's inflammatory diseases are still remain highly relevant, so relapses and chronic inflammation processes are worsen the prognosis for generative function in women, which is an important social and economic problem in modern time. Purpose of the study. Monitoring the effectiveness of therapeutic measures of rehabilitation step in chronic forms of this disease. Materials and methods. We examined 110 patients who handled to the clinic for women with complaints about the absence of pregnancy, of which a survey group was formed. The duration of pelvic inflammatory desiase (PID) in patients of the examination group did not exceed 2 years. The age of the patients was 25-35 years old. In patients of the examination group, according to clinical, laboratory and ultrasound ultrasound, laparoscopy, hysteroscopy and morphological findings, PID was verified including the presence of chronic endometritis and other endometrial pathology (for example, endometrial polyp, simple endometrial hyperplasia). Results. The rehabilitation stage of treatment (6 months) in patients with PID was aimed at restoring the morphofunctional potential of the tissue and eliminating the effects of secondary injuries, which include the restoration of hemodynamics and activity of the endometrial receptors. This stage of treatment is extremely important, especially for reproductive disorders. At this stage, the patients of the examination group were given hormone therapy and treatment with vasoactive drug (dipyridamole). The obtained results testified to the significance of the restoration of the vascular blood flow of the uterus and the functional layer of the endometrium. Conclusion. Rehabilitation therapy in patients with PID was primarily aimed at restoring the functional ability of the endometrium. Hormone therapy was a priority role, but at modern time, role of the vasoactive drugs that affect the blood flow in the uterus is emphasized. One of these drugs is dipyridamole, which contributes to the formation of collaterals (bypass paths) in ischemic zones. The results indicate that at the end of the 6-month rehabilitation phase, than of a three-layer endometrium was diagnosed (according to ultrasound on day 8-10 of the cycle) in 85 (77.27±4.00%) patients in the examination group.


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