Role of Completion Pancreatectomy as a Damage Control Option for Post-Pancreatic Surgical Complications

2006 ◽  
Vol 23 (4) ◽  
pp. 229-234 ◽  
Author(s):  
A. Tamijmarane ◽  
I. Ahmed ◽  
C.S. Bhati ◽  
D.F. Mirza ◽  
A.D. Mayer ◽  
...  
Keyword(s):  
Surgical Complications ◽  
Damage Control ◽  
Control Option ◽  
Completion Pancreatectomy

scholarly journals The Role Of Decompressive Hemnicraniectomies As Damage Control For Ruptured Intracranial Arteriovenous Malformations

2021 ◽  
pp. 101270
Author(s):  
Raphael Bertani ◽  
Stefan W. Koester ◽  
Karl R. Abi-Aad ◽  
Anna R. Kimata ◽  
Kevin L. Ma ◽  
...  
Keyword(s):  
Arteriovenous Malformations ◽  
Damage Control ◽  
Intracranial Arteriovenous Malformations

scholarly journals Corticostriatal Circuits Encode the Subjective Value of Perceived Control

2019 ◽  
Vol 29 (12) ◽  
pp. 5049-5060 ◽  
Author(s):  
Kainan S Wang ◽  
Mauricio R Delgado
Keyword(s):  
Perceived Control ◽  
Well Being ◽  
Control Option ◽  
Subjective Value ◽  
Binary Choices ◽  
Mere Presence ◽  
The Difference ◽  
Neural Underpinnings ◽  
Evoked Activity

AbstractThe ability to perceive and exercise control over an outcome is both desirable and beneficial to our well-being. It has been shown that animals and humans alike exhibit behavioral bias towards seeking control and that such bias recruits the ventromedial prefrontal cortex (vmPFC) and striatum. Yet, this bias remains to be quantitatively captured and studied neurally. Here, we employed a behavioral task to measure the preference for control and characterize its neural underpinnings. Participants made a series of binary choices between having control and no-control over a game for monetary reward. The mere presence of the control option evoked activity in the ventral striatum. Importantly, we manipulated the expected value (EV) of each choice pair to extract the pairing where participants were equally likely to choose either option. The difference in EV between the options at this point of equivalence was inferred as the subjective value of control. Strikingly, perceiving control inflated the reward value of the associated option by 30% and this value inflation was tracked by the vmPFC. Altogether, these results capture the subjective value of perceived control inherent in decision making and highlight the role of corticostriatal circuitry in the perception of control.

Surgical Complications and Causes of Death in Trauma Patients that Require Temporary Abdominal Closure

2005 ◽  
Vol 71 (3) ◽  
pp. 219-224 ◽  
Author(s):  
JosÉ A. Montalvo ◽  
JosÉ A. Acosta ◽  
Pablo RodrÍguez ◽  
Kathia Alejandro ◽  
AndrÉs SÁrraga
Keyword(s):  
Surgical Complications ◽  
Causes Of Death ◽  
Surgical Complication ◽  
Damage Control ◽  
Multiple Logistic Regression Analysis ◽  
Hypovolemic Shock ◽  
Damage Control Surgery ◽  
Trauma Patients ◽  
Temporary Abdominal Closure ◽  
Abdominal Closure

Temporary abdominal closure (TAC) has increasingly been employed in the management of severely injured patients to avoid abdominal compartment syndrome (ACS) and as part of damage control surgery (DCS). Although the use of TAC has received great interest, few data exist describing the morbidity and mortality associated with its use in trauma victims. The main goal of this study is to describe the incidence of surgical complications following the use of TAC as well as to define the mortality associated with this procedure. A retrospective review of patients admitted to a state-designated level 1 trauma center from April 2000 to February 2003 was performed. Inclusion criteria were age >18 years, traumatic injury, and need for exploratory laparotomy and use of TAC. A total of 120 patients were included in the study. The overall mortality of trauma patients requiring TAC was 59.2 per cent. The most common causes of death were acute inflammatory process (50.7%), followed by hypovolemic shock (43.7%). The incidence of surgical complications was 26.6 per cent. Intra-abdominal abscesses were the most frequent surgical complication (10%). After multiple logistic regression analysis, increasing age and a numerically greater initial base deficit were found to be independent predictors of mortality in trauma patients that require TAC.

Role of sunshades in space as a climate control option

2010 ◽  
Vol 67 (1-2) ◽  
pp. 241-253 ◽  
Author(s):  
Takanobu Kosugi
Keyword(s):  
Climate Control ◽  
Control Option

scholarly journals Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

2021 ◽  
Vol 4 (11) ◽  
pp. e202101057
Author(s):  
Danique Beijer ◽  
Thomas Agnew ◽  
Johannes Gregor Matthias Rack ◽  
Evgeniia Prokhorova ◽  
Tine Deconinck ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Function ◽  
Damage Control ◽  
Axonal Neuropathy ◽  
Vital Role ◽  
Adp Ribosylation ◽  
Function Characterization ◽  
Ataxia Syndrome ◽  
Protein Instability

ADP ribosylation is a reversible posttranslational modification mediated by poly(ADP-ribose)transferases (e.g., PARP1) and (ADP-ribosyl)hydrolases (e.g., ARH3 and PARG), ensuring synthesis and removal of mono-ADP-ribose or poly-ADP-ribose chains on protein substrates. Dysregulation of ADP ribosylation signaling has been associated with several neurodegenerative diseases, including Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. Recessive ADPRHL2/ARH3 mutations are described to cause a stress-induced epileptic ataxia syndrome with developmental delay and axonal neuropathy (CONDSIAS). Here, we present two families with a neuropathy predominant disorder and homozygous mutations in ADPRHL2. We characterized a novel C26F mutation, demonstrating protein instability and reduced protein function. Characterization of the recurrent V335G mutant demonstrated mild loss of expression with retained enzymatic activity. Although the V335G mutation retains its mitochondrial localization, it has altered cytosolic/nuclear localization. This minimally affects basal ADP ribosylation but results in elevated nuclear ADP ribosylation during stress, demonstrating the vital role of ADP ribosylation reversal by ARH3 in DNA damage control.

The role of surgery in treating-metastasized urothelial tumors

1992 ◽  
Vol 59 (1_suppl) ◽  
pp. 182-184
Author(s):  
A. Milani ◽  
B. Mangiarotti ◽  
N. Nicolai ◽  
A. Testori
Keyword(s):  
Urinary Tract ◽  
Surgical Treatment ◽  
Surgical Complications ◽  
Overall Response Rate ◽  
Response Rate ◽  
Residual Disease ◽  
Transitional Cell ◽  
Urothelial Tumors ◽  
Pathological Cr

From March 1983 to December 1989 we observed 36 patients with metastatic transitional cell carcinoma of the urinary tract. We treated 22 patients with M-VAC regimen and 14 patients with MP regimen. Overall response rate (CR + PR) was 71.4% in M-VAC group and 50% in MP group. The patients that had PR were 15 and 8 of them underwent surgery of residual disease. One patient had pathological CR and 6 were free of disease after surgical treatment. Out of 7 patients without cancer after surgery, 3 are alive and free of disease after 84, 42 and 26 months. We didn't have surgical complications. Surgery of residual disease after chemotherapy, when possible, is reliable.

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