Identification of Methylation-Associated Gene Expression in Neuroendocrine Pancreatic Tumor Cells

Pancreatology ◽  
2007 ◽  
Vol 7 (4) ◽  
pp. 352-359 ◽  
Author(s):  
Nils Habbe ◽  
Tillmann Bert ◽  
Babette Simon
Keyword(s):  
Gene Expression ◽  
Tumor Cells ◽  
Pancreatic Tumor ◽  
Neuroendocrine Pancreatic Tumor

scholarly journals Smad4/DPC4-dependent Regulation of Biglycan Gene Expression by Transforming Growth Factor-β in Pancreatic Tumor Cells

2002 ◽  
Vol 277 (39) ◽  
pp. 36118-36128 ◽  
Author(s):  
Wen-Bin Chen ◽  
Wolfgang Lenschow ◽  
Karen Tiede ◽  
Jens W. Fischer ◽  
Holger Kalthoff ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Tumor Cells ◽  
Pancreatic Tumor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Leveraging epigenetics to enhance the efficacy of immunotherapy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jonathan D. Licht ◽  
Richard L. Bennett
Keyword(s):  
Gene Expression ◽  
Clinical Trials ◽  
Antigen Presentation ◽  
Tumor Cells ◽  
Immune Evasion ◽  
Regulatory Elements ◽  
Chromatin Accessibility ◽  
Epigenetic Modifications ◽  
Main Body ◽  
Epigenetic Mechanisms

Abstract Background Epigenetic mechanisms regulate chromatin accessibility patterns that govern interaction of transcription machinery with genes and their cis-regulatory elements. Mutations that affect epigenetic mechanisms are common in cancer. Because epigenetic modifications are reversible many anticancer strategies targeting these mechanisms are currently under development and in clinical trials. Main body Here we review evidence suggesting that epigenetic therapeutics can deactivate immunosuppressive gene expression or reprogram tumor cells to activate antigen presentation mechanisms. In addition, the dysregulation of epigenetic mechanisms commonly observed in cancer may alter the immunogenicity of tumor cells and effectiveness of immunotherapies. Conclusions Therapeutics targeting epigenetic mechanisms may be helpful to counter immune evasion and improve the effectiveness of immunotherapies.

scholarly journals Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells

2006 ◽  
Vol 5 (11) ◽  
pp. 1457-1461 ◽  
Author(s):  
Hui-Zhong Zhang ◽  
Yan Wang ◽  
Ping Gao ◽  
Fang Lin ◽  
Li Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Cells ◽  
Malignant Phenotype ◽  
Survivin Promoter

P173 effects of tetrahydroisoquinolines on the POMC gene expression in anterior pituitary tumor cells

1994 ◽  
Vol 2 (1-2) ◽  
pp. 162
Author(s):  
I. Putscher ◽  
H. Haber ◽  
J. Fickel ◽  
A. Winkler ◽  
M. Melzig
Keyword(s):  
Gene Expression ◽  
Tumor Cells ◽  
Pituitary Tumor ◽  
Anterior Pituitary ◽  
Pomc Gene
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