Degenerative Lesions of Spinal Roots and Peripheral Nerves in Aging Rats

Gerontology ◽  
1962 ◽  
Vol 6 (2-3) ◽  
pp. 72-80 ◽  
Author(s):  
Benjamin N. Berg ◽  
Abner Wolf ◽  
Henry S. Simms
Keyword(s):  
Peripheral Nerves ◽  
Aging Rats ◽  
Spinal Roots

scholarly journals Radicular Myelinopathy in Aging Rats

1981 ◽  
Vol 18 (3) ◽  
pp. 335-341 ◽  
Author(s):  
G. Krinke ◽  
J. Suter ◽  
R. Hess
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerves ◽  
Nerve Fibers ◽  
Male Rats ◽  
Aging Rats ◽  
Myelin Sheaths ◽  
Naturally Occurring ◽  
Spinal Roots

Naturally occurring degenerative lesions of nerve fibers in the spinal cord, spinal roots and peripheral nerves in nine male rats 877 days old were swollen myelin sheaths, forming “myelin bubbles.” The myelin swellings were distributed throughout the spinal tracts and the peripheral nerves, but most frequently in the lumbar ventral spinal roots. Although most axons surrounded by swollen myelin were intact, some were constricted and degenerated, while others showed signs of remyelination.

scholarly journals A Rare Case of Anterior Chest Wall Schwannoma Masquerading as a Breast Tumor

2014 ◽  
Vol 99 (3) ◽  
pp. 196-199 ◽  
Author(s):  
Takaaki Fujii ◽  
Reina Yajima ◽  
Hiroki Morita ◽  
Soichi Tsutsumi ◽  
Takayuki Asao ◽  
...  
Keyword(s):  
Peripheral Nerves ◽  
Breast Tumor ◽  
Breast Tissue ◽  
Subcutaneous Tissue ◽  
Anterior Chest Wall ◽  
The Body ◽  
Unusual Site ◽  
Current Case ◽  
Breast Parenchyma ◽  
Spinal Roots

Abstract A schwannoma is a tumor that develops on peripheral nerves or spinal roots. Although any part of the body can be affected, the breast is a quite unusual site for schwannomas. We report herein a case of schwannoma presenting as a breast tumor. In the current case, the tumor showed both clinically and mammographically as a well-defined breast mass. Of interest, sonographically, the well-defined mass appeared to be located in subcutaneous tissue, not in breast parenchyma, and this finding was confirmed histopathologically. These findings indicate the possibility that a schwannoma arising from subcutaneous breast tissue can show exophytic growth to the breast and appear as a breast tumor. In other words, our case implies the possible presence of a “pseudo” breast schwannoma.

scholarly journals Study of clinical profile and outcome of patients with acute non-traumatic paraparesis

2021 ◽  
Vol 10 (1) ◽  
pp. 105
Author(s):  
Sanjana S. Malokar ◽  
Saurabh V. Kothari ◽  
Onkar H. Nadgouda
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerves ◽  
Clinical Presentation ◽  
General Medicine ◽  
Clinical Profile ◽  
Loss Of Function ◽  
Neurological Emergency ◽  
Presenting Symptoms ◽  
Spinal Roots ◽  
Acute Paraplegia

Background: The following study is about the clinical profile and outcome of patients with acute non traumatic paraparesis. It includes the aetiology, clinical presentation and the outcome of various cases of acute non traumatic paraparesis. Paraplegia or paraparesis could be defined as loss of function of both legs as a result of disease or injury of the spinal cord, spinal roots, peripheral nerves or myopathies. Acute non-traumatic paraparesis is a neurological emergency. Reversible causes of acute paraplegia can be treated successfully if diagnosed early.Methods: The observational study was done in the department of general medicine at D. Y. Patil Hospital, Navi Mumbai with sample size of 75 patients over 1 year.Results: With early diagnosis prognosis of acute non traumatic paraparesis can be improved which was evaluated over period of 3 months.Conclusions: Acute non-traumatic paraparesis is a neurological emergency. Reversible causes of acute paraplegia can be treated successfully if diagnosed early. It is important to diagnose and classify all cases into compressive and non-compressive lesions based on presenting symptoms because the management of the two differs.

Spontaneous Degenerative Lesions of Peripheral Nerves in Aging Rats

1981 ◽  
Vol 18 (1) ◽  
pp. 110-113 ◽  
Author(s):  
M. P. Cotard-Bartley ◽  
J. Secchi ◽  
R. Glomot ◽  
J. B. Cavanagh
Keyword(s):  
Peripheral Nerves ◽  
Aging Rats

Dedifferentiation of the Axolemma Associated with Demyelination

1981 ◽  
Vol 39 ◽  
pp. 496-497 ◽  
Author(s):  
J. Rosenbluth ◽  
A. Sumner ◽  
T. Saida
Keyword(s):  
Sodium Channels ◽  
Peripheral Nerves ◽  
Freeze Fracture ◽  
Fracture Analysis ◽  
Nerve Fibers ◽  
High Concentration ◽  
Myelinated Nerve ◽  
Spinal Roots ◽  
Myelin Deficient

Freeze-fracture analysis of myelinated nerve fibers has shown that the axolemma has a highly differentiated structure. The node is characterized by a high concentration of intramembranous particles, primarily in the E fracture face, which may represent the sodium channels known to be concentrated there, and the paranodal axolemma is characterized by a distinctive paracrystalline pattern that corresponds to the intercellular junction formed with the terminal “loops” of myelin lamellae. Studies of myelin formation in normal animals and of myelin-deficient mutant animals indicate that the development of these axolemmal specializations is profoundly influenced by the associated myelinforming cells. The present study considers whether or not nodal or paranodal specializations that have already formed persist after demyelination.In order to investigate this question, specimens of peripheral nerves were examined following exposure to an antiserum to galactocerebroside (GC), which is known to cause a predictable series of changes leading to demyelination. Freeze-fracture replicas of rat spinal roots exposed to anti-GC serum in situ for six hours showed marked changes in the paranodal axolemma.

Conduction of nervous impulses in spinal roots and peripheral nerves of dystrophic mice

1978 ◽  
Vol 143 (1) ◽  
pp. 71-85 ◽  
Author(s):  
Michael Rasminsky ◽  
Robert E. Kearney ◽  
Albert J. Aguayo ◽  
Garth M. Bray
Keyword(s):  
Peripheral Nerves ◽  
Spinal Roots ◽  
Dystrophic Mice

Prostaglandin E2 catabolism in the spinal nerve roots of the cat

1980 ◽  
Vol 58 (2) ◽  
pp. 227-229 ◽  
Author(s):  
I. Bishai ◽  
F. Coceani
Keyword(s):  
Spinal Cord ◽  
Nerve Root ◽  
Peripheral Nerves ◽  
Spinal Nerve ◽  
Spinal Nerve Roots ◽  
Chromatographic Mobility ◽  
Nerve Roots ◽  
Spinal Roots ◽  
Metabolic Degradation ◽  
Rate Limiting

Catabolism of prostaglandin (PG) E2 was studied in homogenates of spinal cord and spinal nerve roots of the cat. Spinal roots enzymatically converted PGE2 to a product (metabolite I) with the chromatographic mobility of 15-keto-PGE2. Little metabolic degradation occurred in the spinal cord; however, incubation of PGE2 with combined spinal cord and nerve root tissue yielded a second metabolite (metabolite II) in addition to metabolite I. Metabolite II was identified as 15-keto-13,14-dihydro-PGE2. These results prove that spinal nerve roots, unlike the spinal cord, contain 15-hydroxyprostaglandin dehydrogenase (15-PGDH) which is the major and rate-limiting enzyme in the inactivation of prostaglandins. The location and functional significance of 15-PGDH in peripheral nerves remain to be elucidated.

Effects of crush injury on the abnormalities in the spinal roots and peripheral nerves of dystrophic mice

1983 ◽  
Vol 6 (7) ◽  
pp. 497-503 ◽  
Author(s):  
Garth M. Bray ◽  
Samuel David ◽  
Thomas Carlstedt ◽  
Albert J. Aguayo
Keyword(s):  
Peripheral Nerves ◽  
Crush Injury ◽  
Spinal Roots ◽  
Dystrophic Mice

Basil Kilvington

1993 ◽  
Vol 18 (4) ◽  
pp. 461-464 ◽  
Author(s):  
M. A. GLASBY ◽  
T. E. J. HEMS
Keyword(s):  
Peripheral Nerves ◽  
Surgical Repair ◽  
Early History ◽  
Early Years ◽  
History Of ◽  
Spinal Roots

In the early years of the present century, a group of experiments assessing the results of the surgical repair of peripheral nerves and spinal roots was performed by Basil Kilvington. The outcome of the experiments was assessed using both electrophysiological and morphological techniques. Much of Kilvington’s work remained unrecognized and was thus repeated at a later date. Kilvington’s role in the early history of the surgical repair of nerves appears to have been forgotten and his substantial and prophetic discoveries deserve better recognition.

Sign in / Sign up

Export Citation Format

Share Document