Clinical Evaluation of Short-Term Defibrotide Treatment of Patients with Atherosclerosis obliterans of the Lower Limbs

The aim of the investigation was to study the morphological condition of blood cells in the basins of the ischemic limbs and their dynamics as a result of various types of surgical treatment. Implementation of combined surgical treatment has a more normalizing effect in comparison with isolated reconstructive surgical treatment. The use of lumbar sympathectomy in patients with occlusive lesions of arteries of lower limbs and varying degrees of ischemia reduces endothelial dysfunction and normalizes a number of parameters describing the morphology and functioning of red blood cells and platelets. There was detected the deformation of red blood cells indicating that the restoration of the plasticity of red blood cell membranes significally reduced the degree of agglutination of red blood cells. According to obtained data the influence of sympathectomy depends on the severity of the disease in general the highest efficiency is observed at the II and III degree of ischemia.

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Short-term Gait Parameters Change in Mild Spastic Cerebral Palsy after Selective Dorsal Rhizotomy Guided by Our Newly-Modified Protocol

10.21203/rs.3.rs-278334/v1 ◽

2021 ◽

Author(s):

wenbin jiang ◽

Shuyun Jiang ◽

Yan Yu ◽

Qijia Zhan ◽

Min Wei ◽

...

Keyword(s):

Cerebral Palsy ◽

Lower Limbs ◽

Spastic Cerebral Palsy ◽

Selective Dorsal Rhizotomy ◽

Short Term ◽

Term Outcome ◽

Long Term Outcome ◽

Dorsal Rhizotomy ◽

Gait Parameters

Abstract Background Selective Dorsal Rhizotomy (SDR) guided by our modified protocol can decrease spasticity in certain muscles. This study aimed to investigate gait parameters changes in cerebral palsy (CP) with focal spasticity after SDR in short-term follow-up. Methods CP classified as Gross Motor Function Classification System (GMFCS) level Ⅰ and Ⅱ who underwent SDR were included. Changes of spasticity, gait parameters and gait deviation index (GDI) were retrospectively reviewed. Results This study contained 26 individuals with 44 affected and 8 intact lower limbs (4 monoplegia, 4 hemiplegia and 18 diplegia). Mean age was 5.7 ± 1.9 years-old and follow-up duration was 9.9 ± 6.6 months. After SDR, average spasticity of 108 target muscles decreased from 2.9 ± 0.8 to 1.8 ± 0.6 in Modified Ashworth Scale (MAS). Kinematic curves changed after the surgery in sagittal and transverse plane in affected sides, further investigation showed improvements in ankle and knee. No changes were found in temporal-spatial parameters except decrease in cadence in affected sides. GDI improved significantly in affected limbs. Conclusion In short-term follow up, the new-protocol-guiding SDR can lower focal spasticity, GA showed improvements in kinematic parameters and GDI. Longer follow-up duration is needed to clarify the long-term outcome.

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Oral sirolimus for prevention of recurrent infrainguinal arterial obstructions after surgical and endovascular revascularizations

VASA ◽

10.1024/0301-1526.37.3.285 ◽

2008 ◽

Vol 37 (3) ◽

pp. 285-288 ◽

Cited By ~ 2

Author(s):

Keo ◽

Do ◽

Husmann ◽

Baumgartner

Keyword(s):

Arterial Disease ◽

Lower Limbs ◽

Rest Pain ◽

Short Term ◽

The Third ◽

Neointimal Proliferation ◽

Arterial Lesions ◽

Peripheral Arterial ◽

Case Basis

No data are currently available on the role of oral sirolimus in the prevention of recurrent stenosis in the periphery. We report the effects of oral sirolimus in the prevention of recurrent infrainguinal obstructions in patients with complex peripheral arterial disease. Three patients with ischemic rest pain of the lower limbs and repeated short-term need for surgical and/or endovascular revascularization: 9 times within 12 months, 7 times within 15 months, 11 times within 26 months, respectively. Oral sirolimus on a case by case basis, resulted in less frequent restenosis and longer intervention-free intervals: three re-interventions within 37 months in the first patient, one balloon angioplasty within 17 months in the second, and three re-interventions within 21 months in the third patient, respectively. Side effects, in particular dyspepsia and diarrhoea, were mild and tolerable. To our knowledge, this is the first report to show that oral sirolimus was successfully administered in patients with recurrent excessive neointimal proliferation after revascularization of peripheral arterial lesions lowering the necessity of re-intervention and hence prolonging intervention-free intervals.

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Clinical evaluation of a novel press-fit acetabular cup using “Ein-Bild-Roentgen-Analysis” (EBRA): A positive short-term prognosis

Journal of Orthopaedics ◽

10.1016/j.jor.2020.03.059 ◽

2020 ◽

Vol 22 ◽

pp. 33-37

Author(s):

B.A. Ishaque ◽

J. Wieczorek ◽

C.A. Fonseca Ulloa ◽

J.B. Seeger ◽

G.A. Ahmed ◽

...

Keyword(s):

Clinical Evaluation ◽

Acetabular Cup ◽

Short Term ◽

Press Fit

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Post‐surgical flap placement following osseous surgery: A short‐term clinical evaluation

Journal of Periodontology ◽

10.1002/jper.19-0238 ◽

2019 ◽

Vol 91 (4) ◽

pp. 501-507

Author(s):

Jeffrey K. Penner ◽

David E. Deas ◽

Michael P. Mills ◽

John Hanlon ◽

Jonathan Gelfond ◽

...

Keyword(s):

Clinical Evaluation ◽

Surgical Flap ◽

Short Term

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History of lobotomy in Poland

History of Psychiatry ◽

10.1177/0957154x17741231 ◽

2017 ◽

Vol 29 (1) ◽

pp. 3-21 ◽

Cited By ~ 1

Author(s):

Kinga Jęczmińska

Keyword(s):

Clinical Research ◽

Clinical Evaluation ◽

Long Term Results ◽

Short Term ◽

History Of

In Poland, there were 176 cases of prefrontal leucotomy performed by Moniz’s method between 1947 and 1951. There were also several cases in which alternative psychosurgical techniques were used: prefrontal topectomy by Bilikiewicz and colleagues, and prefrontal topischemia by Ziemnowicz. This article analyses the following: publications by Choróbski, who performed lobotomy in Poland, and by Korzeniowski, who assessed its short-term results; a report by Bornsztajn, who reviewed general results of the method; and clinical research by Broszkiewicz and by Konieczyńska, who assessed Polish patients in terms of long-term results of lobotomy. Negative clinical evaluation of lobotomy led to its abandonment in Poland, a decision strengthened by a regulation that forbade lobotomy in the USSR and impacted Polish psychiatry.

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