Allergic Bronchopulmonary Aspergillosis in Asthmatic Patients Presenting with Allergic Rhinitis

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

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Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.2006.03007.x ◽

2006 ◽

Vol 143 (3) ◽

pp. 414-419 ◽

Cited By ~ 56

Author(s):

S. Kaur ◽

V. K. Gupta ◽

A. Shah ◽

S. Thiel ◽

P. U. Sarma ◽

...

Keyword(s):

Allergic Rhinitis ◽

Bronchial Asthma ◽

Allergic Bronchopulmonary Aspergillosis ◽

Intronic Polymorphism

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Safety and Tolerability of Rupatadine Administered to Asthmatic Patients With Persistent Allergic Rhinitis

CHEST Journal ◽

10.1016/j.chest.2016.08.1075 ◽

2016 ◽

Vol 150 (4) ◽

pp. 971A

Author(s):

Paraschiva Postolache ◽

Narcisa Vrinceanu ◽

Liliana Chelaru ◽

Cristina Lacatusi ◽

Daniela Husanu ◽

...

Keyword(s):

Allergic Rhinitis ◽

Asthmatic Patients ◽

Persistent Allergic Rhinitis

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Effects of leukotriene D4 nasal challenge on bronchial responsiveness and inflammation in asthmatic patients with allergic rhinitis

Journal of Thoracic Disease ◽

10.21037/jtd.2017.02.36 ◽

2017 ◽

Vol 9 (2) ◽

pp. 271-277

Author(s):

Zheng Zhu ◽

Yanqing Xie ◽

Weijie Guan ◽

Yi Gao ◽

Rongquan Huang ◽

...

Keyword(s):

Allergic Rhinitis ◽

Leukotriene D4 ◽

Bronchial Responsiveness ◽

Asthmatic Patients ◽

Nasal Challenge

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Molecular identification of the main allergens present in household dust of asthmatic patients

Ciência e Natura ◽

10.5902/2179460x41091 ◽

2020 ◽

Vol 42 ◽

pp. e17

Author(s):

Hyngrid Carolinne Soares Ferreira Moreira ◽

Sâmia Melo Santos ◽

Matheus Silva Alves ◽

Maryangela Godinho Pereira Bena ◽

Giselmo Pinheiro Lopes ◽

...

Keyword(s):

Allergic Rhinitis ◽

House Dust ◽

International Study ◽

Household Dust ◽

Chain Reactions ◽

Asthmatic Children ◽

Asthmatic Patients ◽

Polymerase Chain Reactions ◽

Predominant Factor ◽

Polymerase Chain

Introduction: The main aeroallergens present in house dust are the mites,Dermatophagoidespteronyssinus (Derp) andDermatophagoidesfarinae (Derf), and cockroaches,Periplanetaamericana (Pera). Objective: This work aims to genetically identify the allergens Derp, Derf, and Pera in household dust of asthmatic patients. Materials and methods: 29 patients, aged between 3 and 17 years, were classified as asthmatic or non-asthmatic according to the International Study of Asthma and Allergies in Childhood(ISAAC). Subjectscompleted a complementary questionnaire and skin hypersensitivity tests were performed. House dust was collected from these patients, filtered, and then DNA was extracted. Polymerase chain reactions were performed to identify Derp, Derf, and Pera in the samples. Results: There was an association between Pera sensitization and onset of asthma. There was also an association between the presence of Derp in the home of asthmatic patients and the worsening of symptoms, such as wheezing in the chest and allergic rhinitis. An association between the presence of Derf in house dust of asthmatic patients and the symptoms of allergic rhinitis was found. These data suggest that cockroach sensitization is a predominant factor in asthmatic children and the presence of mite allergens contributesto the worsening of asthma symptoms.

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Allergic bronchopulmonar aspergillosis in asthmatic patients

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja455 ◽

2015 ◽

Vol 12 (2) ◽

pp. 37-46

Author(s):

Y I Kozlova ◽

A V Sobolev ◽

E V Frolova ◽

O V Aak ◽

E V Burygina ◽

...

Keyword(s):

Cystic Fibrosis ◽

Working Group ◽

Clinical Case ◽

Clinical Course ◽

Correct Diagnosis ◽

Allergic Bronchopulmonary Aspergillosis ◽

Poor Control ◽

Asthmatic Patients ◽

Number Of Patients ◽

The World

Allergic bronchopulmonary aspergillosis (ABPA) is a caused by hypersensitivity to Aspergillus spp. antigens, is the lung disease, which occurs in patients with asthma or cystic fibrosis and is characterized by poor control of background disease and development of respiratory failure. According to experts opinion the number of patients with ABPA is about four million people in the world and 175 000 persons in Russian Federation. The clinical course improvement, prevention of progression and prophylaxis of bronchiectasis depend on timely and correct diagnosis of the disease. International Society of Human and Animal Mycology (ISHAM) formed a working group «ABPA in patients with asthma» for worldwide collaboration with physicians and researchers. The working group proposed new diagnostic criteria. This report presents a clinical case of ABPA in asthmatic patient. The diagnosis is established according criteria proposed by R. Agarwal et al., 2013.

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