Enhancement of the Bronchial Reactivity in Immunized Rats by Neonatal Treatment with Capsaicin

ABSTRACT Male newborn rats were injected with 2 mg of an antiandrogen (1,2α-methylene-6-chloro-pregna-4,6-dien-17α-ol-3,20-dione-17α-acetate = cyproterone acetate) daily from their 1st to their 14th day of life. The following effects of this treatment were observed in these animals after onset of sexual maturity: 84% of the animals are unable to reproduce. Penis: the frenulum is broadened to a lamina of triangular shape, which almost completely prevents the preputium from being pushed back. These males show a rather insufficient male sexual behaviour towards females in oestrus. After castration and ovar implantation, some of the treated animals show true corpora lutea and at attempts of cohabitation partially female sexual behaviour towards normal male animals. From these results it can be concluded, that differentiation of the penis is not completed at the time of birth. The infertility of the animals may be caused by the penile changes (difficulties with intromission) as well as by the aimless sexual behaviour. This aimless sexual behaviour, the ability to produce true corpora lutea and finally their partially female sexual attitude under the influence of the hormones from the implanted ovaries led to the conclusion, that the above described neonatal treatment apparently inhibited testosterone-depending post partum developments of sexual differentiation in hypothalamic centers.

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PS-139 Neurodevelopment Within The First Two Years After Implementation Of The Euroconsortium Neonatal Treatment Protocol In Congenital Diaphragmatic Hernia Patients: A Multicenter Study

Archives of Disease in Childhood ◽

10.1136/archdischild-2014-307384.435 ◽

2014 ◽

Vol 99 (Suppl 2) ◽

pp. A161.1-A161

Author(s):

KG Snoek ◽

I Capolupo ◽

L Aite ◽

A Braguglia ◽

RMH Wijnen ◽

...

Keyword(s):

Congenital Diaphragmatic Hernia ◽

Diaphragmatic Hernia ◽

Multicenter Study ◽

Treatment Protocol ◽

Neonatal Treatment

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Cough as the sole manifestation of airway hyperreactivity

The Journal of Laryngology & Otology ◽

10.1017/s0022215100109715 ◽

1989 ◽

Vol 103 (7) ◽

pp. 680-682 ◽

Cited By ~ 3

Author(s):

A Frans ◽

J Van Den Eeckhaut

Keyword(s):

Allergic Rhinitis ◽

Respiratory Symptoms ◽

Challenge Test ◽

General Medicine ◽

Airway Hyperreactivity ◽

Bronchial Reactivity ◽

Inhaled Steroids ◽

Reactivity Test ◽

History Of ◽

Predominantly Female

Abstract The authors report 18 patients who presented to the ENT department with isolated cough, which had begun one month to 14 years previously. As the ENT examination was negative, the patients were referred to the Department of General Medicine where a bronchial reactivity test with acetylcholine was found to be positive, leading to a diagnosis of airway hyperreactivity. The group was predominantly female (15/18) and atopy was rare; indeed, only one patient, who had a history of allergic rhinitis, was found to be atopic. Bronchodilators and inhaled steroids cured or helped the cough in 16/18 patients. When a patient presents with chronic cough without other respiratory symptoms it is important to consider a diagnosis of airway hyperreactivity and to confirm this with a challenge test of bronchoconstriction

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