Magnetic Resonance Imaging in Breath-Hold Divers with Cerebral Decompression Sickness

Objective.The volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) technique can visualize erosive cartilage defects in peripheral joints. We evaluated the ability of VIBE to detect erosions in sacroiliac joints (SIJ) of patients with axial spondyloarthritis (axSpA) compared to the established T1-weighted MRI sequence and computed tomography (CT).Methods.MRI (T1-weighted and VIBE) and CT scans of SIJ of 109 patients with axSpA were evaluated by 2 blinded readers based on SIJ quadrants (SQ). Erosions were defined according to Assessment of Spondyloarthritis international Society (ASAS) definitions. Scores were recorded if readers were in agreement.Results.Erosions were less frequently detected by CT (153 SQ) than by T1-weighted MRI (182 SQ; p = 0.008) and VIBE-MRI (199 SQ; p < 0.001 vs CT and p = 0.031 vs T1-weighted MRI). Taking CT as the gold standard, the sensitivity of VIBE-MRI (71.2%) was higher than that for T1-weighted MRI (63.4%), with similar specificity (87.3% vs 88%, respectively). In linear regression analysis, younger age was significantly associated with occurrence of erosions independently in VIBE-MRI (β = 0.384, p < 0.001) and T1-weighted MRI (β = 0.369, p < 0.001) compared to CT.Conclusion.The VIBE-MRI sequence was more sensitive than T1-weighted MRI in identifying erosive damage in the SIJ, especially in younger patients. This might be due to the ability of VIBE-MRI to identify structural changes in the cartilage that have not yet extended to the underlying bone, where CT seems to be superior.

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Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis

European Respiratory Journal ◽

10.1183/13993003.02188-2018 ◽

2019 ◽

Vol 53 (5) ◽

pp. 1802188 ◽

Cited By ~ 18

Author(s):

Jonathan H. Rayment ◽

Marcus J. Couch ◽

Nancy McDonald ◽

Nikhil Kanhere ◽

David Manson ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Cystic Fibrosis ◽

Magnetic Resonance ◽

Lung Disease ◽

Treatment Response ◽

Forced Expiratory Volume ◽

Response To Therapy ◽

Breath Hold ◽

Pulmonary Exacerbation ◽

Resonance Imaging

Pulmonary magnetic resonance imaging using hyperpolarised 129Xe gas (XeMRI) can quantify ventilation inhomogeneity by measuring the percentage of unventilated lung volume (ventilation defect per cent (VDP)). While previous studies have demonstrated its sensitivity for detecting early cystic fibrosis (CF) lung disease, the utility of XeMRI to monitor response to therapy in CF is unknown. The aim of this study was to assess the ability of XeMRI to capture treatment response in paediatric CF patients undergoing inpatient antibiotic treatment for a pulmonary exacerbation.15 CF patients aged 8–18 years underwent XeMRI, spirometry, plethysmography and multiple-breath nitrogen washout at the beginning and end of inpatient treatment of a pulmonary exacerbation. VDP was calculated from XeMRI images obtained during a static breath hold using semi-automated k-means clustering and linear binning approaches.XeMRI was well tolerated. VDP, lung clearance index and the forced expiratory volume in 1 s all improved with treatment; however, response was not uniform in individual patients. Of all outcome measures, VDP showed the largest relative improvement (−42.1%, 95% CI −52.1–−31.9%, p<0.0001).These data support further investigation of XeMRI as a tool to capture treatment response in CF lung disease.

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Fat-Suppressed Dynamic and Delayed Gadolinium-Enhanced Volumetric Interpolated Breath-hold Magnetic Resonance Imaging of Cholangiocarcinoma

Journal of Computer Assisted Tomography ◽

10.1097/rct.0b013e31806bef8e ◽

2008 ◽

Vol 32 (2) ◽

pp. 178-184 ◽

Cited By ~ 4

Author(s):

John R. Leyendecker ◽

Mandip Gakhal ◽

Khaled M. Elsayes ◽

Ronan McDermott ◽

Vamsidhar R. Narra ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Breath Hold ◽

Resonance Imaging

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Analyses of displacement of the heart and its substructures caused by cardiac movement and identification of compensatory margins based on breath-hold electrocardiograph-gated 4-dimensional magnetic resonance imaging for oesophageal radiotherapy

10.21203/rs.3.rs-58655/v1 ◽

2020 ◽

Author(s):

Guanghui Yang ◽

Chengrui Fu ◽

Guanzhong Gong ◽

Jing Zhang ◽

Qian Wang ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Papillary Muscle ◽

Cardiac Cycle ◽

Left Ventricular ◽

Breath Hold ◽

Resonance Imaging ◽

4D Mri ◽

Planning Ct ◽

Anterior Posterior

Abstract Background: Cardiac movement can affect the accuracy of the evaluation of the location of heart and its substructures by planning computed tomography (CT). We aimed to measure the margin displacement and calculate compensatory margins through breath-hold electrocardiograph (ECG)-gated 4-dimensional magnetic resonance imaging (4D-MRI) for oesophageal radiotherapy.Methods: The study enrolled 10 patients with oesophageal radiotherapy plans and pretreatment 4D-MRI data. The displacement of the heart and its substructures was measured between the end of the systolic and diastolic phases in one cardiac cycle. The compensatory margins were calculated by extending the planning CT to cover the internal target volume (ITV) of all structures. Differences between groups were tested with the Kruskal-Wallis H test.Results: The extent of movement of the heart and its substructures during one cardiac cycle were approximately 4.0-26.1 mm in the anterior-posterior (AP),left-right (LR), and cranial-caudal (CC) axes, and the compensatory margins should be applied to the planning CT by extending the margins by 1.7, 3.6, 1.8, 3.0, 2.1, and 2.9 mm for the pericardium, 1.2, 2.5, 1.0, 2.8, 1.8, and 3.3 mm for the heart, 3.8, 3.4, 3.1, 2.8, 0.9, and 2.0 mm for the interatrial septum, 3.3, 4.9, 2.0, 4.1, 1.1, and 2.9 mm for the interventricular septum, 2.2, 3.0, 1.1, 5.3, 1.8, and 2.4 mm for the left ventricular muscle (LVM), 5.9, 3.4, 2.1, 6.1, 5.4, and 3.6 mm for the antero-lateral papillary muscle (ALPM), and 6.6, 2.9, 2.6, 6.6, 3.9, and 4.8 mm for the postero-medial papillary muscle (PMPM) in the anterior, posterior, left, right, cranial, and caudal directions.Conclusions: The locations of the heart and its substructures determined by planning CT were not able to represent the true positions due to cardiac movement, and compensatory margins can be applied to decrease the influence of movement.

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